{"text_format":"3","workbook":"xlsx","n_sheets":2,"sheets":["General Information","L6000-Ubiquitination-213 cpds"],"not_rendered":{"images":2,"defined_names":1},"read":"whole","date_system":"1900"}

{"sheet":"General Information","index":0,"n_rows":94,"n_cols":14,"rows_kept":94,"merged":[[0,3,0,13],[1,1,1,13],[2,0,2,13],[3,1,3,13],[4,1,4,2],[4,3,4,13],[5,1,5,2],[5,3,5,13],[6,1,7,2],[6,3,6,13],[7,3,7,13],[8,1,8,2],[8,3,8,13],[9,1,10,2],[9,3,9,13],[10,3,10,13],[14,1,14,13],[16,1,17,1],[16,2,17,2],[16,13,17,13],[18,1,19,1],[18,2,19,2],[18,13,19,13],[20,1,21,1],[20,2,21,2],[20,13,21,13],[22,1,23,1],[22,2,23,2],[22,13,23,13],[24,1,25,1],[24,2,25,2],[24,13,25,13],[26,1,27,1],[26,2,27,2],[26,13,27,13],[28,1,29,1],[28,2,29,2],[28,13,29,13],[30,1,31,1],[30,2,31,2],[30,13,31,13],[35,1,35,13],[37,1,38,1],[37,2,38,2],[37,13,38,13],[39,1,40,1],[39,2,40,2],[39,13,40,13],[41,1,42,1],[41,2,42,2],[41,13,42,13],[43,1,44,1],[43,2,44,2],[43,13,44,13],[45,1,46,1],[45,2,46,2],[45,13,46,13],[47,1,48,1],[47,2,48,2],[47,13,48,13],[49,1,50,1],[49,2,50,2],[49,13,50,13],[51,1,52,1],[51,2,52,2],[51,13,52,13],[56,1,56,13],[58,1,59,1],[58,2,59,2],[58,9,59,9],[58,10,59,10],[58,11,59,11],[58,12,59,12],[58,13,59,13],[60,1,61,1],[60,2,61,2],[60,9,61,9],[60,10,61,10],[60,11,61,11],[60,12,61,12],[60,13,61,13],[62,1,63,1],[62,2,63,2],[62,9,63,9],[62,10,63,10],[62,11,63,11],[62,12,63,12],[62,13,63,13],[64,1,65,1],[64,2,65,2],[64,9,65,9],[64,10,65,10],[64,11,65,11],[64,12,65,12],[64,13,65,13],[66,1,67,1],[66,2,67,2],[66,9,67,9],[66,10,67,10],[66,11,67,11],[66,12,67,12],[66,13,67,13],[68,1,69,1],[68,2,69,2],[68,9,69,9],[68,10,69,10],[68,11,69,11],[68,12,69,12],[68,13,69,13],[70,1,71,1],[70,2,71,2],[70,8,71,8],[70,9,71,9],[70,10,71,10],[70,11,71,11],[70,12,71,12],[70,13,71,13],[72,1,73,1],[72,2,73,2],[72,8,73,8],[72,9,73,9],[72,10,73,10],[72,11,73,11],[72,12,73,12],[72,13,73,13],[77,1,77,13],[79,1,80,1],[79,2,80,2],[79,4,80,4],[79,5,80,5],[79,6,80,6],[79,7,80,7],[79,8,80,8],[79,9,80,9],[79,10,80,10],[79,11,80,11],[79,12,80,12],[79,13,80,13],[81,1,82,1],[81,2,82,2],[81,4,82,4],[81,5,82,5],[81,6,82,6],[81,7,82,7],[81,8,82,8],[81,9,82,9],[81,10,82,10],[81,11,82,11],[81,12,82,12],[81,13,82,13],[83,1,84,1],[83,2,84,2],[83,4,84,4],[83,5,84,5],[83,6,84,6],[83,7,84,7],[83,8,84,8],[83,9,84,9],[83,10,84,10],[83,11,84,11],[83,12,84,12],[83,13,84,13],[85,1,86,1],[85,2,86,2],[85,4,86,4],[85,5,86,5],[85,6,86,6],[85,7,86,7],[85,8,86,8],[85,9,86,9],[85,10,86,10],[85,11,86,11],[85,12,86,12],[85,13,86,13],[87,1,88,1],[87,2,88,2],[87,4,88,4],[87,5,88,5],[87,6,88,6],[87,7,88,7],[87,8,88,8],[87,9,88,9],[87,10,88,10],[87,11,88,11],[87,12,88,12],[87,13,88,13],[89,1,90,1],[89,2,90,2],[89,4,90,4],[89,5,90,5],[89,6,90,6],[89,7,90,7],[89,8,90,8],[89,9,90,9],[89,10,90,10],[89,11,90,11],[89,12,90,12],[89,13,90,13],[91,1,92,1],[91,2,92,2],[91,4,92,4],[91,5,92,5],[91,6,92,6],[91,7,92,7],[91,8,92,8],[91,9,92,9],[91,10,92,10],[91,11,92,11],[91,12,92,12],[91,13,92,13],[93,1,94,1],[93,2,94,2],[93,3,94,3],[93,4,94,4],[93,5,94,5],[93,6,94,6],[93,7,94,7],[93,8,94,8],[93,9,94,9],[93,10,94,10],[93,11,94,11],[93,12,94,12],[93,13,94,13]]}
[{"$nulls":3},"Ubiquitination Compound Library (96-well)-L6000"]
[null,"For more information on Selleck library service, please contact us via +1-832-582-8158 or library@selleckchem.com"]
[]
[null,"Product Details:"]
[null,"Description",null,"A unique collection of 213 compounds"]
[null,"Container",null,"96 Well"]
[null,"Stability",null,"12 months | ﹣20°C | in DMSO"]
[{"$nulls":3},"24 months | ﹣80°C | in DMSO"]
[null,"Shipping",null,"Blue ice or Dry ice"]
[null,"Formulation",null,"Solubility ≥10 mM pre-dissolved in 10 mM solution and solubility between 2 mM and 10 mM pre-dissolved in 2 mM solution"]
[{"$nulls":3},"In 10 mM DMSO : Plate layout L6000-01~03;    In 2 mM DMSO : Plate layout L6000-04"]
[]
[]
[]
[null,"Plate layout: L6000-01"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1013","S1157","S1523","S2180","S2321","S2662","S2811","S3137","S3867","S4937","Empty"]
[{"$nulls":3},"Bortezomib (PS-341)","Delanzomib (CEP-18770)","Voxtalisib (XL765) Analogue","Ixazomib (MLN2238)","Magnolol","Foscenvivint (ICG-001)","Sapanisertib (MLN0128)","Sodium salicylate","(E)-Cardamonin","4'-Hydroxychalcone"]
[null,"b","Empty","S1022","S1172","S1555","S2181","S2341","S2689","S2817","S3604","S3874","S5003","Empty"]
[{"$nulls":3},"Ridaforolimus (Deforolimus, MK-8669)","Serdemetan (JNJ-26854165)","AZD8055","Ixazomib Citrate (MLN9708) Analogue","(-)-Parthenolide","WAY-600","Torin 2","Triptolide (PG490)","Curcumenol","Tacrolimus (FK506)"]
[null,"c","Empty","S1029","S1180","S1567","S2218","S2406","S2696","S2824","S3612","S4073","S5315","Empty"]
[{"$nulls":3},"Lenalidomide (CC-5013)","XAV-939","Pomalidomide (CC-4047)","Torkinib (PP242)","Chrysophanic Acid","Apitolisib (GDC-0980)","TPCA-1","Rosmarinic acid","Sodium 4-Aminosalicylate","PRT4165"]
[null,"d","Empty","S1038","S1193","S1681","S2225","S2619","S2743","S2853","S3615","S4712","S5815","Empty"]
[{"$nulls":3},"PI-103","Thalidomide (K17)","Mesalamine (5-ASA)","TAME","MG132","PF-04691502","Carfilzomib (PR-171)","Dehydrocostus Lactone","Diethylmaleate","WAY-316606"]
[null,"e","Empty","S1039","S1226","S1774","S2238","S2622","S2749","S2863","S3630","S4902","S5841","Empty"]
[{"$nulls":3},"Rapamycin (AY-22989)","KU-0063794","Thioguanine (NSC 752)","Palomid 529 (P529)","PP121","BGT226 (NVP-BGT226) maleate","Nodinitib-1","Methyl Vanillate","QNZ (EVP4593)","DKM 2-93"]
[null,"f","Empty","S1044","S1266","S1786","S2243","S2624","S2754","S2864","S3633","S4907","S7030","Empty"]
[{"$nulls":3},"Temsirolimus (CCI-779)","WYE-354","Verteporfin (CL 318952)","Degrasyn (WP1130)","OSI-027","Xevinapant (AT406)","IMD 0354","Pyrrolidinedithiocarbamate ammonium","SC-514","RG-7112"]
[null,"g","Empty","S1061","S1274","S1848","S2261","S2658","S2781","S2882","S3692","S4920","S7037","Empty"]
[{"$nulls":3},"Nutlin-3","BX-795","Curcumin","Andrographolide","Omipalisib (GSK2126458)","RITA (NSC 652287)","IKK-16 (IKK Inhibitor VII)","N-Ethylmaleimide (NEM)","b-AP15","Wnt-C59 (C59)"]
[null,"h","Empty","S1120","S1290","S2101","S2313","S2661","S2783","S2913","S3842","S4921","S7038","Empty"]
[{"$nulls":3},"Everolimus (RAD001)","Celastrol (NSC 70931)","Gabexate Mesylate","Indole-3-carbinol","WYE-125132 (WYE-132)","Vistusertib (AZD2014)","BAY 11-7082","Isoquercitrin","MNS (3,4-Methylenedioxy-β-nitrostyrene)","Epoxomicin (BU-4061T)"]
[]
[]
[]
[null,"Plate layout: L6000-02"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S7049","S7134","S7285","S7441","S7649","S7888","S8044","S8248","S8327","S8642","Empty"]
[{"$nulls":3},"Oprozomib (ONX 0912)","IU1","NMS-873","WS3","MI-773 (SAR405838)","Spautin-1","BMS-345541","IQ-1","KYA1797K","GSK'963"]
[null,"b","Empty","S7086","S7135","S7301","S7442","S7672","S7891","S8050","S8261","S8334","S8644","Empty"]
[{"$nulls":3},"IWR-1-endo","LDN-57444","IWP-L6","WS6","Omaveloxolone (RTA-408)","CC-115","ETP-46464","GSK583","XMU-MP-1","GNF-6231"]
[null,"c","Empty","S7091","S7140","S7351","S7462","S7691","S7892","S8065","S8279","S8403","S8645","Empty"]
[{"$nulls":3},"Zotarolimus (ABT-578)","TCID","JSH-23","PI-1840","PS-1145","Avadomide (CC-122)","Nutlin-3b","(±)-Shikonin","MX69","IWP-O1"]
[null,"d","Empty","S7096","S7142","S7352","S7484","S7697","S7933","S8078","S8288","S8429","S8647","Empty"]
[{"$nulls":3},"KY02111","NSC697923","Bay 11-7085","FH535","LY2409881","VR23","Bardoxolone Methyl","VLX1570","PNU-74654","iCRT3"]
[null,"e","Empty","S7129","S7143","S7386","S7489","S7811","S7948","S8101","S8298","S8474","S8652","Empty"]
[{"$nulls":3},"PYR-41","LGK-974","MG-101 (ALLN)","YH239-EE","MHY1485","MRT67307 HCl","CB-5083","CZ415","LF3","Skp2 inhibitor C1 (SKPin C1)"]
[null,"f","Empty","S7130","S7199","S7396","S7490","S7851","S7954","S8163","S8317","S8483","S8661","Empty"]
[{"$nulls":3},"PR-619","DBeQ","Calpeptin","WIKI4","AZD3264","CP21R7 (CP21)","Paxalisib (GDC-0084)","3BDO","CBL0137 HCl","CA3 (CIL56)"]
[null,"g","Empty","S7132","S7205","S7414","S7529","S7875","S8000","S8177","S8320","S8484","S8696","Empty"]
[{"$nulls":3},"P5091 (P005091)","Idasanutlin (RG-7388)","Caffeic Acid Phenethyl Ester","ML323","NVP-CGM097","Tenovin-1","BH3I-1","SKL2001","GSK2982772","2-D08"]
[null,"h","Empty","S7133","S7273","S7424","S7646","S7886","S8040","S8178","S8322","S8589","S8738","Empty"]
[{"$nulls":3},"P22077","SC75741","PD 151746","Voxtalisib (XL765)","Onatasertib (CC 223)","GDC-0349","Wnt agonist 1","Samotolisib (LY3023414)","SF2523","Bimiralisib (PQR309)"]
[]
[]
[]
[null,"Plate layout: L6000-03"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S8760","S9159","S0346","S8975","E0392","S9865","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Iberdomide (CC220)","momordin-Ic","NAcM-OPT","Mezigdomide (CC-92480)","Dubs-IN-1","CB-5339"]
[null,"b","Empty","S8761","S8904","S3269","S9605","E1214","E1412","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Adavivint (SM04690)","USP25/28 inhibitor AZ1","Acetylcorynoline","Apcin","KSQ-4279","DEG-35"]
[null,"c","Empty","S9042","S4922","S6845","S0515","E1215","E1575","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Wedelolactone","NSC 632839","GRL0617","PLpro inhibitor","JQAD1","EN450"]
[null,"d","Empty","S9106","S6794","S6851","S0884","E1216","E1812","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Eleutheroside E","Thalidomide-O-COOH (Cereblon ligand 3)","RA-190","RA-9","Heclin","N6F11"]
[null,"e","Empty","S9432","S8888","S6877","S8979","E1300","E1413","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Ginkgolic Acid","GMB-475","EOAI3402143","THAL-SNS-032","SJ6986","DEG-77"]
[null,"f","Empty","S9445","S0095","S6878","S9444","E1330","E1479","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Ginkgolic Acid (C13:0)","VL285","GSK2643943A","Tomatine","Usp22i-S02","I-138"]
[null,"g","Empty","S6748","S0097","S7394","S4432","E1381","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"ML364","(S,R,S)-AHPC (MDK7526)","MDL-28170","Ixazomib Citrate (MLN9708)","NX-2127"]
[null,"h","Empty","S9416","S0219","S8449","S9724","E1427","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Triptonide","ML241 hydrochloride","VH298","SZL P1-41","MRT-2359"]
[]
[]
[]
[null,"Plate layout: L6000-04"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1360","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"GSK1059615"]
[null,"b","Empty","S2628","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Gedatolisib (PKI-587)"]
[null,"c","Empty","S2827","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Torin 1"]
[null,"d","Empty","S7035","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"XL388"]
[null,"e","Empty","S7085","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"IWP-2"]
[null,"f","Empty","S0399","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"SJB2-043"]
[null,"g","Empty","E1678","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"SPOP-i-6lc"]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]

{"sheet":"L6000-Ubiquitination-213 cpds","index":1,"n_rows":214,"n_cols":23,"rows_kept":214}
["Cat","Name","Plate Location","Rack Number","Formulation","Target","Pathway","Information","M.w.","CAS Number","DMSO (mg/mL)Max Solubility","DMSO (mM)Max Solubility","Water (mg/mL)Max Solubility","Water (mM)Max Solubility","URL","Formula","Form","Synonyms","SMILES","ALogP","HBA_Count","HBD_Count","RotatableBond"]
["S1013","Bortezomib (PS-341)","a2","L6000-01","in 10mM DMSO","Autophagy,Cathepsin B,Cysteine Protease,ERK,NF-κB,Proteasome","Proteases","Bortezomib (PS-341, Velcade, LDP-341, MLM341, NSC 681239) is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.",384.24,"179324-69-7",{"v":76,"d":"76.00"},197.79,"<1","N/A","http://selleckchem.com/products/Bortezomib.html","C19H25BN4O4","Free Base","Velcade, LDP-341, MLM341, NSC 681239,PS-341","CC(C)CC(NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)B(O)O",2.183,4,2,9]
["S1022","Ridaforolimus (Deforolimus, MK-8669)","b2","L6000-01","in 10mM DMSO","FKBP,mTOR","PI3K/Akt/mTOR","Ridaforolimus (Deforolimus, MK-8669, AP23573) is a selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line; while not classified as a prodrug, mTOR inhibition and FKBP12 binding is similar to rapamycin. Phase 3.",990.21,"572924-54-0",{"v":198,"d":"198.00"},199.96,"<1","N/A","http://selleckchem.com/products/Deforolimus.html","C53H84NO14P","free base","AP23573","COC1CC(CCC1O[P](C)(C)=O)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.303,12,1,8]
["S1029","Lenalidomide (CC-5013)","c2","L6000-01","in 10mM DMSO","Apoptosis related,Caspase,E3 Ligase ,E3 ligase Ligand,TNF-alpha,VEGFR","Ubiquitin","Lenalidomide (CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.",259.26,"191732-72-6",{"v":52,"d":"52.00"},200.57,"<1","N/A","https://www.selleckchem.com/products/lenalidomide-s1029.html","C13H13N3O3","free base","CC-5013","NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1",-0.515,3,2,1]
["S1038","PI-103","d2","L6000-01","in 10mM DMSO","Apoptosis related,Autophagy,DNA-PK,mTOR,PI3K","PI3K/Akt/mTOR","PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. PI-103 induces apoptosis in murine T-cell Lymphoma.",348.36,"371935-74-9",{"v":24,"d":"24.00"},68.89,"<1","N/A","http://selleckchem.com/products/PI-103.html","C19H16N4O3","free base","N/A","OC1=CC(=CC=C1)C2=NC3=C(OC4=C3C=CC=N4)C(=N2)N5CCOCC5",2.798,5,1,2]
["S1039","Rapamycin (AY-22989)","e2","L6000-01","in 10mM DMSO","Antineoplastic and Immunosuppressive Antibiotics,Autophagy,mTOR","PI3K/Akt/mTOR","Rapamycin (AY-22989, Rapamune, Sirolimus, NSC-2260804,AY-22989) is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.",914.18,"53123-88-9",{"v":20,"d":"20.00"},21.88,"<1","N/A","http://selleckchem.com/products/Rapamycin.html","C51H79NO13","free base","Rapamune, Sirolimus, NSC-2260804,AY-22989","COC1CC(CCC1O)CC(C)C2CC(=O)C(C)\\C=C(/C)C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.295,10,2,6]
["S1044","Temsirolimus (CCI-779)","f2","L6000-01","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay. Temsirolimus induces autophagy and apoptosis.",1030.29,"162635-04-3",{"v":67,"d":"67.00"},65.03,"<1","N/A","http://selleckchem.com/products/Temsirolimus.html","C56H87NO16","free base","NSC 683864,CCI-779","COC1CC(CCC1OC(=O)C(C)(CO)CO)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.039,12,3,11]
["S1061","Nutlin-3","g2","L6000-01","in 10mM DMSO","E3 Ligase ,MDM2/MDMX","Apoptosis","Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.",{"v":581.5,"d":"581.50"},"890090-75-2",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/Nutlin-3.html","C30H30Cl2N4O4","free base","N/A","COC1=CC(=C(C=C1)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5)OC(C)C",5.434,5,1,6]
["S1120","Everolimus (RAD001)","h2","L6000-01","in 10mM DMSO","Apoptosis related,Autophagy,FKBP,mTOR","PI3K/Akt/mTOR","Everolimus (RAD001, SDZ-RAD, Afinitor) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM in a cell-free assay. Everolimus induces cell apoptosis and autophagy and inhibits tumor cells proliferation.",958.22,"159351-69-6",{"v":100,"d":"100.00"},104.36,"<1","N/A","http://selleckchem.com/products/Everolimus(RAD001).html","C53H83NO14","free base","RAD001,SDZ-RAD, Afinitor","COC1CC(CCC1OCCO)CC(C)C2CC(=O)C(C)\\C=C(C)\\C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC",6.164,11,2,9]
["S1157","Delanzomib (CEP-18770)","a3","L6000-01","in 10mM DMSO","Proteasome","Proteases","Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome with IC50 of 3.8 nM, with only marginal inhibition of the tryptic and peptidylglutamyl activities of the proteosome. Phase 1/2.",413.28,"847499-27-8",{"v":83,"d":"83.00"},200.83,"<1","N/A","http://selleckchem.com/products/cep-18770.html","C21H28BN3O5","free base","N/A","CC(C)C(CNC(=O)C(NC(=O)C1=NC(=CC=C1)C2=CC=CC=C2)C(C)O)B(O)O",2.646,3,3,9]
["S1172","Serdemetan (JNJ-26854165)","b3","L6000-01","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.",328.41,"881202-45-5",{"v":66,"d":"66.00"},200.97,"<1","N/A","http://selleckchem.com/products/JNJ-26854165.html","C21H20N4","free base","N/A","C(CC1=C[NH]C2=CC=CC=C12)NC3=CC=C(NC4=CC=NC=C4)C=C3",4.236,1,3,6]
["S1180","XAV-939","c3","L6000-01","in 10mM DMSO","PARP,Wnt/beta-catenin","Stem Cells & Wnt","XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.",312.31,"284028-89-3",{"v":12,"d":"12.00"},38.42,"<1","N/A","http://selleckchem.com/products/XAV-939.html","C14H11F3N2OS","free base","NVP-XAV939","OC1=C2CSCCC2=NC(=N1)C3=CC=C(C=C3)C(F)(F)F",3.676,2,1,2]
["S1193","Thalidomide (K17)","d3","L6000-01","in 10mM DMSO","E3 Ligase ,E3 ligase Ligand,TNF-alpha","Ubiquitin","Thalidomide (K17) was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1.",258.23,"50-35-1",{"v":51,"d":"51.00"},{"v":197.5,"d":"197.50"},"<1","N/A","http://selleckchem.com/products/Thalidomide.html","C13H10N2O4","free base","K17","O=C1CCC(N2C(=O)C3=C(C=CC=C3)C2=O)C(=O)N1",0.097,4,1,1]
["S1226","KU-0063794","e3","L6000-01","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2 with IC50 of ~10 nM in cell-free assays; no effect on PI3Ks.",465.54,"938440-64-3",{"v":16,"d":"16.00"},34.37,"<1","N/A","http://selleckchem.com/products/KU-0063794.html","C25H31N5O4","free base","N/A","COC1=C(CO)C=C(C=C1)C2=NC3=NC(=NC(=C3C=C2)N4CCOCC4)N5CC(C)OC(C)C5",3.274,6,1,5]
["S1266","WYE-354","f3","L6000-01","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) not P-AKT(T308), selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).",495.53,"1062169-56-5",{"v":99,"d":"99.00"},199.79,"<1","N/A","http://selleckchem.com/products/WYE-354.html","C24H29N7O5","free base","N/A","COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=N[N]3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5",1.886,8,1,6]
["S1274","BX-795","g3","L6000-01","in 10mM DMSO","Autophagy,IκB/IKK,PDPK1,TBK1","PI3K/Akt/mTOR","BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.",591.47,"702675-74-9",{"v":100,"d":"100.00"},169.07,"<1","N/A","http://selleckchem.com/products/bx-795.html","C23H26IN7O2S","free base","N/A","IC1=CN=C(NC2=CC(=CC=C2)NC(=O)N3CCCC3)N=C1NCCCNC(=O)C4=CC=CS4",3.704,4,4,9]
["S1290","Celastrol (NSC 70931)","h3","L6000-01","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,Proteasome","Proteases","Celastrol (NSC 70931, Tripterine) is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.",450.61,"34157-83-0",{"v":90,"d":"90.00"},199.73,"<1","N/A","http://selleckchem.com/products/Celastrol.html","C29H38O4","free base","Tripterine","CC1=C(O)C(=O)C=C2C1=CC=C3C2(C)CCC4(C)C5CC(C)(CCC5(C)CCC34C)C(O)=O",5.475,2,1,1]
["S1523","Voxtalisib (XL765) Analogue","a4","L6000-01","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Voxtalisib (SAR245409, XL765) Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.",599.66,"1349796-36-6",{"v":12,"d":"12.00"},20.01,"<1","N/A","http://selleckchem.com/products/XL765(SAR245409).html","C31H29N5O6S","free base","SAR245409","COC1=CC(=CC(=C1)NC2=NC3=CC=CC=C3N=C2N[S](=O)(=O)C4=CC=C(NC(=O)C5=CC=C(C)C(=C5)OC)C=C4)OC",5.631,8,3,10]
["S1555","AZD8055","b4","L6000-01","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity (∼1,000-fold) against PI3K isoforms and ATM/DNA-PK. AZD8055 induces caspase-dependent apoptosis and also induces autophagy. Phase 1.",465.54,"1009298-09-2",{"v":50,"d":"50.00"},{"v":107.4,"d":"107.40"},"<1","N/A","http://selleckchem.com/products/AZD8055.html","C25H31N5O4","free base","N/A","COC1=C(CO)C=C(C=C1)C2=NC3=C(C=C2)C(=NC(=N3)N4CCOCC4C)N5CCOCC5C",3.274,6,1,5]
["S1567","Pomalidomide (CC-4047)","c4","L6000-01","in 10mM DMSO","Apoptosis related,E3 Ligase ,E3 ligase Ligand,TNF-alpha","Ubiquitin","Pomalidomide (CC-4047) inhibits LPS-induced TNF-α release with IC50 of 13 nM in PBMCs. Pomalidomide can be utilized in PROTAC as a ligand for targeting E3 ligase and inhibiting the E3 ligase protein cereblon (CRBN). Pomalidomide promotes apoptosis and cell cycle arrest.",273.24,"19171-19-8",{"v":54,"d":"54.00"},197.63,"<1","N/A","http://selleckchem.com/products/Pomalidomide(CC-4047).html","C13H11N3O4","free base","CC-4047","NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1",{"v":-0.65,"d":"-0.650"},4,2,1]
["S1681","Mesalamine (5-ASA)","d4","L6000-01","in 10mM DMSO","Immunology & Inflammation related,IκB/IKK","NF-κB","Mesalamine (5-Aminosalicylic acid, 5-ASA, Mesalazine, Apriso, Asacol, Pentasa, Canasa) is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.",153.14,"89-57-6",{"v":31,"d":"31.00"},202.43,"<1","N/A","http://selleckchem.com/products/Mesalamine(Lialda).html","C7H7NO3","free base","5-Aminosalicylic acid, 5-ASA, Mesalazine, Apriso, Asacol, Pentasa, Canasa","NC1=CC=C(O)C(=C1)C(O)=O",0.471,1,2,1]
["S1774","Thioguanine (NSC 752)","e4","L6000-01","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Thioguanine (NSC 752, 6-Thioguanine, 2-Amino-6-purinethiol), a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.",167.19,"154-42-7",{"v":9,"d":"9.00"},53.83,"<1","N/A","http://selleckchem.com/products/Thioguanine.html","C5H5N5S","free base","NSC 752,6-Thioguanine, 2-Amino-6-purinethiol","NC1=NC(=S)C2=C(N1)N=C[NH]2",0.236,2,3,0]
["S1786","Verteporfin (CL 318952)","f4","L6000-01","in 10mM DMSO","Apoptosis related,Autophagy,TEAD,VDA,YAP","Angiogenesis","Verteporfin (CL 318952, Visudyne) is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth.  It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis.",718.79,"129497-78-5",{"v":100,"d":"100.00"},139.12,"<1","N/A","http://selleckchem.com/products/Verteporfin(Visudyne).html","C41H42N4O8","free base","CL 318952, Visudyne","COC(=O)CCC1=C(C)C2=CC3=NC(=CC4=C(C)C(=C([NH]4)C=C5N=C(C=C1[NH]2)C(=C5C)CCC(O)=O)C=C)C6=CC=C(C(C(=O)OC)C36C)C(=O)OC",7.789,9,2,12]
["S1848","Curcumin","g4","L6000-01","in 10mM DMSO","Apoptosis related,Autophagy,Epigenetic Reader Domain,Ferroptosis,HCV,HDAC,Histone Acetyltransferase,HIV,Influenza Virus,NF-κB,Nrf2","Epigenetics","Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.",368.38,"458-37-7",{"v":73,"d":"73.00"},198.16,"<1","N/A","http://selleckchem.com/products/Curcumin.html","C21H20O6","free base","Diferuloylmethane, Natural Yellow 3, Turmeric yellow","COC1=CC(=CC=C1O)/C=C/C(O)=C/C(=O)/C=C/C2=CC(=C(O)C=C2)OC",3.573,3,3,7]
["S2101","Gabexate Mesylate","h4","L6000-01","in 10mM DMSO","Serine Protease","Proteases","Gabexate Mesylate(FOY) is a serine protease inhibitor with IC50 of 0.19 μM which is used therapeutically in the treatment of pancreatitis and disseminated intravascular coagulation.",417.48,"56974-61-9",{"v":83,"d":"83.00"},198.81,{"v":12,"d":"12.00"},28.74,"http://selleckchem.com/products/gabexate-mesylate.html","C16H23N3O4.CH4O3S","Mesylate","FOY","CCOC(=O)C1=CC=C(OC(=O)CCCCCNC(N)=N)C=C1.C[S](O)(=O)=O",1.774,4,2,12]
["S2180","Ixazomib (MLN2238)","a5","L6000-01","in 10mM DMSO","Autophagy,Proteasome","Proteases","Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. Ixazomib (MLN2238) induces autophagy. Phase 3.",361.03,"1072833-77-2",{"v":72,"d":"72.00"},199.43,"<1","N/A","http://selleckchem.com/products/MLN-2238.html","C14H19BCl2N2O4","Free Base","N/A","CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B(O)O",3.344,2,2,7]
["S2181","Ixazomib Citrate (MLN9708) Analogue","b5","L6000-01","in 10mM DMSO","Autophagy,Proteasome","Proteases","Ixazomib Citrate (MLN9708) Analogue is the analogue of Ixazomib Citrate (MLN9708) from WO2016165677A1. Ixazomib Citrate (MLN9708) immediately hydrolyzed to Ixazomib (MLN2238), the biologically active form, on exposure to aqueous solutions or plasma. Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50/Ki of 3.4 nM/0.93 nM in cell-free assays, less potent to β1 and little activity to β2. Ixazomib (MLN2238) induces autophagy. Phase 3.",517.12,"1201902-80-8",{"v":100,"d":"100.00"},193.38,"<1","N/A","http://selleckchem.com/products/MLN9708.html","C20H23BCl2N2O9","free base","N/A","CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B2OC(=O)CC(CC(O)=O)(O2)C(O)=O",3.497,7,2,10]
["S2218","Torkinib (PP242)","c5","L6000-01","in 10mM DMSO","Apoptosis related,Autophagy,Mitophagy,mTOR","PI3K/Akt/mTOR","Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively. Torkinib (PP242) induces mitophagy and apoptosis.",308.34,"1092351-67-1",{"v":61,"d":"61.00"},197.83,"<1","N/A","http://selleckchem.com/products/PP242.html","C16H16N6O","free base","N/A","CC(C)[N]1N=C(C2=CC3=C([NH]2)C=CC(=C3)O)C4=C(N)N=CN=C14",2.908,3,3,2]
["S2225","TAME","d5","L6000-01","in 10mM DMSO","APC,E3 Ligase","Cell Cycle","Tosyl-L-Arginine Methyl Ester (TAME) is an APC inhibitor.",342.41,"901-47-3",{"v":69,"d":"69.00"},201.51,{"v":69,"d":"69.00"},201.51,"http://selleckchem.com/products/TAME.html","C14H22N4O4S","free base","N/A","COC(=O)C(CCCNC(N)=N)N[S](=O)(=O)C1=CC=C(C)C=C1",0.749,4,3,10]
["S2238","Palomid 529 (P529)","e5","L6000-01","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Palomid 529 (P529, SG 00529) inhibits both the mTORC1 and mTORC2 complexes, reduces phosphorylation of pAktS473, pGSK3βS9, and pS6. Phase 1.",406.43,"914913-88-5",{"v":81,"d":"81.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/Palomid-529-P529.html","C24H22O6","free base","SG 00529","COC1=CC=C(COC2=C(OC)C=C3C(=C2)OC(=O)C4=C3C=CC(=C4)C(C)O)C=C1",4.257,5,1,6]
["S2243","Degrasyn (WP1130)","f5","L6000-01","in 10mM DMSO","Apoptosis related,Autophagy,Bcr-Abl,DUB","Angiogenesis","Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). Degrasyn (WP1130) induces apoptosis and blocks autophagy.",384.27,"856243-80-6",{"v":77,"d":"77.00"},200.38,"<1","N/A","http://selleckchem.com/products/WP1130.html","C19H18BrN3O","free base","N/A","CCCC(NC(=O)/C(=C/C1=NC(=CC=C1)Br)C#N)C2=CC=CC=C2",4.546,2,1,6]
["S2261","Andrographolide","g5","L6000-01","in 10mM DMSO","NF-κB","NF-κB","Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata.",350.45,"5508-58-7",{"v":70,"d":"70.00"},199.74,"<1","N/A","http://selleckchem.com/products/Andrographolide.html","C20H30O5","free base","N/A","CC1(CO)C(O)CCC2(C)C(C\\C=C\\3C(O)COC3=O)C(=C)CCC12",2.056,2,3,3]
["S2313","Indole-3-carbinol","h5","L6000-01","in 10mM DMSO","NF-κB","NF-κB","Indole-3-carbinol is produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables. Indole-3-carbinol suppresses NF-κB and IκBα kinase activation.",147.18,"700-06-1",{"v":29,"d":"29.00"},197.04,{"v":7,"d":"7.00"},47.56,"http://selleckchem.com/products/Indole-3-carbinol.html","C9H9NO","free base","N/A","OCC1=C[NH]C2=C1C=CC=C2",1.518,0,2,1]
["S2321","Magnolol","a6","L6000-01","in 10mM DMSO","Fungal,NF-κB","NF-κB","Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.",266.33,"528-43-8",{"v":53,"d":"53.00"},{"v":199,"d":"199.00"},"<1","N/A","http://selleckchem.com/products/Magnolol(2,2-Bichavicol).html","C18H18O2","free base","NSC 293099","OC1=C(C=C(CC=C)C=C1)C2=CC(=CC=C2O)CC=C",{"v":4.88,"d":"4.880"},0,2,5]
["S2341","(-)-Parthenolide","b6","L6000-01","in 10mM DMSO","HDAC,MDM2/MDMX,NF-κB,p53","NF-κB","(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.",248.32,"20554-84-1",{"v":49,"d":"49.00"},197.33,"<1","N/A","http://selleckchem.com/products/Parthenolide((-)-Parthenolide).html","C15H20O3","free base","N/A","CC/1=C\\CCC2(C)OC2C3OC(=O)C(=C)C3CC1",2.923,3,0,0]
["S2406","Chrysophanic Acid","c6","L6000-01","in 10mM DMSO","EGFR,mTOR","Protein Tyrosine Kinase","Chrysophanic Acid (Chrysophanol) a natural anthraquinone isolated from Dianella longifolia, is a EGFR/mTOR pathway inhibitor.",254.24,"481-74-3",{"v":5,"d":"5.00"},19.67,"<1","N/A","http://selleckchem.com/products/Chrysophanic-acid-Chrysophanol.html","C15H10O4","free base","Chrysophanol","CC1=CC2=C(C(=C1)O)C(=O)C3=C(O)C=CC=C3C2=O",{"v":2.81,"d":"2.810"},2,2,0]
["S2619","MG132","d6","L6000-01","in 10mM DMSO","Proteasome","Proteases","MG132 ((S,R,S)-(-)-MG132, Z-Leu-D-Leu-Leu-al) is a potent proteasome (ChTL, TL, and PGPH) inhibitor.  MG132 also inhibits calpain (IC50=1.2 μM).",475.62,"1211877-36-9",{"v":90,"d":"90.00"},189.23,"<1","N/A","http://selleckchem.com/products/MG132.html","C26H41N3O5","free base","(S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al","CC(C)CC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)C=O",4.371,5,3,15]
["S2622","PP121","e6","L6000-01","in 10mM DMSO","Bcr-Abl,DNA-PK,mTOR,PDGFR,Src,VEGFR","Protein Tyrosine Kinase","PP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM.",319.36,"1092788-83-4",{"v":64,"d":"64.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/PP121.html","C17H17N7","free base","N/A","NC1=NC=NC2=C1C(=N[N]2C3CCCC3)C4=CN=C5[NH]C=CC5=C4",2.583,4,2,2]
["S2624","OSI-027","f6","L6000-01","in 10mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","OSI-027 (ASP4786, CERC 006, AEVI-006) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα, PI3Kβ, PI3Kγ or DNA-PK. OSI-027 induces autophagy in cancer cells.",406.44,"936890-98-1",{"v":18,"d":"18.00"},44.29,"<1","N/A","http://selleckchem.com/products/OSI027.html","C21H22N6O3","free base","ASP4786, CERC 006, AEVI-006","COC1=CC=CC2=C1[NH]C(=C2)C3=C4[N](N=CN=C4N)C(=N3)C5CCC(CC5)C(O)=O",3.376,5,2,4]
["S2658","Omipalisib (GSK2126458)","g6","L6000-01","in 10mM DMSO","Autophagy,mTOR,PI3K","PI3K/Akt/mTOR","Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy. Phase 1.",{"v":505.5,"d":"505.50"},"1086062-66-9",{"v":100,"d":"100.00"},197.82,"<1","N/A","http://selleckchem.com/products/gsk2126458.html","C25H17F2N5O3S","free base","GSK458","COC1=NC=C(C=C1N[S](=O)(=O)C2=CC=C(F)C=C2F)C3=CC=C4N=CC=C(C5=CC=NN=C5)C4=C3",3.705,7,1,6]
["S2661","WYE-125132 (WYE-132)","h6","L6000-01","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WYE-125132 (WYE-132) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.",{"v":519.6,"d":"519.60"},"1144068-46-1",{"v":104,"d":"104.00"},200.15,"<1","N/A","http://selleckchem.com/products/wye-125132.html","C27H33N7O4","free base","N/A","CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=N[N]3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7",2.093,7,2,4]
["S2662","Foscenvivint (ICG-001)","a7","L6000-01","in 10mM DMSO","Apoptosis related,Epigenetic Reader Domain,Wnt/beta-catenin","Stem Cells & Wnt","Foscenvivint (ICG-001) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to CREB-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. ICG-001 induces apoptosis.",548.63,"780757-88-2 (relative stereochemistry); 847591-62-2 (absolute stereochemistry)",{"v":100,"d":"100.00"},182.27,"<1","N/A","http://selleckchem.com/products/icg-001.html","C33H32N4O4","free base","N/A","OC1=CC=C(CC2N3C(CN(CC4=CC=CC5=C4C=CC=C5)C2=O)N(CCC3=O)C(=O)NCC6=CC=CC=C6)C=C1",4.065,3,2,6]
["S2689","WAY-600","b7","L6000-01","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).",494.59,"1062159-35-6",{"v":22,"d":"22.00"},44.48,"<1","N/A","http://selleckchem.com/products/way-600.html","C28H30N8O","free base","N/A","C1CN(CCO1)C2=NC(=NC3=C2C=N[N]3C4CCN(CC4)CC5=CC=CN=C5)C6=CC7=C([NH]C=C7)C=C6",2.946,5,1,5]
["S2696","Apitolisib (GDC-0980)","c7","L6000-01","in 10mM DMSO","Apoptosis related,Autophagy,mTOR,PI3K","PI3K/Akt/mTOR","Apitolisib (GDC-0980, RG7422, GNE 390) is a potent, class I PI3K inhibitor for PI3Kα/β/δ/γ with IC50 of 5 nM/27 nM/7 nM/14 nM in cell-free assays, respectively. Also a mTOR inhibitor with Ki of 17 nM in a cell-free assay, and highly selective versus other PIKK family kinases. Apitolisib activates autophagy and apoptosis simultaneously in pancreatic cancer cells. Phase 2.",{"v":498.6,"d":"498.60"},"1032754-93-0",{"v":20,"d":"20.00"},40.11,"<1","N/A","http://selleckchem.com/products/GDC-0980-RG7422.html","C23H30N8O3S","free base","RG7422, GNE 390","CC(O)C(=O)N1CCN(CC1)CC2=C(C)C3=NC(=NC(=C3S2)N4CCOCC4)C5=CN=C(N)N=C5",1.013,6,2,5]
["S2743","PF-04691502","d7","L6000-01","in 10mM DMSO","Akt,Apoptosis related,mTOR,PI3K","PI3K/Akt/mTOR","PF-04691502 (PF4691502) is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1, p70S6K, MEK, ERK, p38, or JNK. PF-04691502 induces apoptosis. Phase 2.",425.48,"1013101-36-4",{"v":14,"d":"14.00"},{"v":32.9,"d":"32.90"},"<1","N/A","http://selleckchem.com/products/pf-04691502.html","C22H27N5O4","free base","PF4691502","COC1=CC=C(C=N1)C2=CC3=C(C)N=C(N)N=C3N(C4CCC(CC4)OCCO)C2=O",1.616,6,2,6]
["S2749","BGT226 (NVP-BGT226) maleate","e7","L6000-01","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.",{"v":650.6,"d":"650.60"},"1245537-68-1",{"v":30,"d":"30.00"},46.11,"<1","N/A","http://selleckchem.com/products/nvp-bgt226.html","C28H25F3N6O2.C4H4O","maleate","N/A","COC1=NC=C(C=C1)C2=CC=C3N=CC4=C(N(C(=O)N4C)C5=CC(=C(C=C5)N6CCNCC6)C(F)(F)F)C3=C2.OC(=O)\\C=C/C(O)=O",1.618,6,1,7]
["S2754","Xevinapant (AT406)","f7","L6000-01","in 10mM DMSO","E3 Ligase ,IAP","Apoptosis","Xevinapant (AT406, ARRY-334543, Debio1143, SM-406) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.",561.71,"1071992-99-8",{"v":100,"d":"100.00"},178.03,"<1","N/A","http://selleckchem.com/products/at-406.html","C32H43N5O4","free base","ARRY-334543, Debio1143, SM-406","CNC(C)C(=O)NC1CN(CCC2CCC(N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C",2.264,4,3,9]
["S2781","RITA (NSC 652287)","g7","L6000-01","in 10mM DMSO","E3 Ligase ,p53","Apoptosis","RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.",292.37,"213261-59-7",{"v":58,"d":"58.00"},198.38,"<1","N/A","http://selleckchem.com/products/rita-nsc-652287.html","C14H12O3S2","free base","N/A","OCC1=CC=C(S1)C2=CC=C(O2)C3=CC=C(CO)S3",3.407,1,2,4]
["S2783","Vistusertib (AZD2014)","h7","L6000-01","in 10mM DMSO","Apoptosis related,Autophagy,mTOR","PI3K/Akt/mTOR","Vistusertib (AZD2014) is a novel mTOR inhibitor with IC50 of 2.8 nM in a cell-free assay; highly selective against multiple PI3K isoforms (α/β/γ/δ). AZD2014 showed no or weak binding to the majority of kinases when tested at 1 μM. AZD2014 induces proliferation suppression, apoptosis, cell cycle arrest, and autophagy in HCC cells with antitumor activity.",462.54,"1009298-59-2",{"v":38,"d":"38.00"},82.16,"<1","N/A","http://selleckchem.com/products/azd2014.html","C25H30N6O3","free base","N/A","CNC(=O)C1=CC=CC(=C1)C2=CC=C3C(=N2)N=C(N=C3N4CCOCC4C)N5CCOCC5C",3.103,6,1,4]
["S2811","Sapanisertib (MLN0128)","a8","L6000-01","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Sapanisertib (MLN0128, INK 128, TAK-228) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Phase 1.",309.33,"1224844-38-5",{"v":62,"d":"62.00"},200.43,"<1","N/A","http://selleckchem.com/products/ink128.html","C15H15N7O","free base","INK 128,TAK-228","CC(C)[N]1N=C(C2=CC3=C(OC(=N3)N)C=C2)C4=C(N)N=CN=C14",1.886,5,2,2]
["S2817","Torin 2","b8","L6000-01","in 10mM DMSO","Apoptosis related,ATM/ATR,Autophagy,DNA-PK,mTOR","PI3K/Akt/mTOR","Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM in p53−/− MEFs cell line; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM,in PC3 cell lines respectively. Torin 2 decreases cell viability and induces autophagy and apoptosis.",{"v":432.4,"d":"432.40"},"1223001-51-1",{"v":20,"d":"20.00"},46.25,"<1","N/A","http://selleckchem.com/products/torin-2.html","C24H15F3N4O","free base","N/A","NC1=CC=C(C=N1)C2=CC=C3N=CC4=C(N(C(=O)C=C4)C5=CC=CC(=C5)C(F)(F)F)C3=C2",4.323,3,1,3]
["S2824","TPCA-1","c8","L6000-01","in 10mM DMSO","Apoptosis related,IκB/IKK,NF-κB,STAT","NF-κB","TPCA-1 (GW683965) is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. TPCA-1 is also an inhibitor of STAT3 and enhances apoptosis.",279.29,"507475-17-4",{"v":56,"d":"56.00"},200.51,"<1","N/A","http://selleckchem.com/products/tpca-1.html","C12H10FN3O2S","free base","GW683965","NC(=O)NC1=C(C=C(S1)C2=CC=C(F)C=C2)C(N)=O",1.544,2,3,3]
["S2853","Carfilzomib (PR-171)","d8","L6000-01","in 10mM DMSO","Apoptosis related,Autophagy,COVID-19,Proteasome","Proteases","Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.",719.91,"868540-17-4",{"v":50,"d":"50.00"},69.45,"<1","N/A","http://selleckchem.com/products/carfilzomib-pr-171.html","C40H57N5O7","free base","N/A","CC(C)CC(NC(=O)C(CCC1=CC=CC=C1)NC(=O)CN2CCOCC2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC(C)C)C(=O)C4(C)CO4",3.799,7,4,20]
["S2863","Nodinitib-1","e8","L6000-01","in 10mM DMSO","NOD","NF-κB","Nodinitib-1(ML130) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2.",287.34,"799264-47-4",{"v":57,"d":"57.00"},198.37,"<1","N/A","http://selleckchem.com/products/ml130.html","C14H13N3O2S","free base","ML130","CC1=CC=C(C=C1)[S](=O)(=O)[N]2C(=NC3=CC=CC=C23)N",2.984,3,1,2]
["S2864","IMD 0354","f8","L6000-01","in 10mM DMSO","IκB/IKK","NF-κB","IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and blocks IκBα phosphorylation in NF-κB pathway.",383.67,"978-62-1",{"v":10,"d":"10.00"},26.06,"<1","N/A","http://selleckchem.com/products/imd-0354.html","C15H8ClF6NO2","free base","IKK2 Inhibitor V","OC1=C(C=C(Cl)C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F",4.921,1,2,4]
["S2882","IKK-16 (IKK Inhibitor VII)","g8","L6000-01","in 10mM DMSO","IκB/IKK,LRRK2","NF-κB","IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively. IKK-16 also inhibits LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro with IC50 of 50 nM.",483.63,"873225-46-8",{"v":97,"d":"97.00"},200.57,"<1","N/A","http://selleckchem.com/products/ikk-16.html","C28H29N5OS","free base","N/A","O=C(N1CCC(CC1)N2CCCC2)C3=CC=C(NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5)C=C3",5.208,3,1,5]
["S2913","BAY 11-7082","h8","L6000-01","in 10mM DMSO","Apoptosis related,DUB,IκB/IKK","NF-κB","BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells.",207.25,"19542-67-7",{"v":41,"d":"41.00"},197.83,"<1","N/A","http://selleckchem.com/products/bay-11-7082-bay-11-7821.html","C10H9NO2S","free base","BAY 11-7821","CC1=CC=C(C=C1)[S](=O)(=O)\\C=C\\C#N",1.721,2,0,2]
["S3137","Sodium salicylate","a9","L6000-01","in 10mM DMSO","NF-κB","NF-κB","Sodium salicylate(2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt) is used in medicine as an analgesic and antipyretic.",161.11,"54-21-7",{"v":32,"d":"32.00"},198.62,{"v":32,"d":"32.00"},198.62,"http://selleckchem.com/products/sodium-salicylate.html","C7H6O3.Na","sodium salt","2-Hydroxybenzoic acid Sodium salt,Salicylic acid Sodium salt","[NaH].OC(=O)C1=CC=CC=C1O",1.217,1,1,1]
["S3604","Triptolide (PG490)","b9","L6000-01","in 10mM DMSO","ADC Cytotoxin,Apoptosis related,HSP (HSP90),MDM2/MDMX,NF-κB","NF-κB","Triptolide (PG490, NSC 163062) is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1). Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.",{"v":360.4,"d":"360.40"},"38748-32-2",{"v":72,"d":"72.00"},199.78,"<1","N/A","http://selleckchem.com/products/triptolide.html","C20H24O6","free base","NSC 163062","CC(C)C12OC1C3OC34C5(C)CCC6=C(COC6=O)C5CC7OC47C2O",0.872,5,1,1]
["S3612","Rosmarinic acid","c9","L6000-01","in 10mM DMSO","Complement System,IκB/IKK","NF-κB","Rosmarinic acid (RA, Rosemary acid) is a naturally occurring hydroxylated compound. It has the ability to block complement fixation, inhibit lipoxygenase and cyclooxygenase activity and inhibit the expression of CCL11 and CCR3 by suppressing the IKK-β activity in NF-κB activation signaling.",360.31,"20283-92-5",{"v":72,"d":"72.00"},199.83,{"v":24,"d":"24.00"},66.61,"http://selleckchem.com/products/rosmarinic-acid.html","C18H16O8","free base","Rosemary acid","OC(=O)C(CC1=CC=C(O)C(=C1)O)OC(=O)\\C=C\\C2=CC=C(O)C(=C2)O",2.706,3,4,7]
["S3615","Dehydrocostus Lactone","d9","L6000-01","in 10mM DMSO","IκB/IKK","NF-κB","Dehydrocostus lactone (DHE), a natural sesquiterpene lactone, inhibits IKKβ activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter. It has anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.",{"v":230.3,"d":"230.30"},"477-43-0",{"v":46,"d":"46.00"},199.74,"<1","N/A","http://selleckchem.com/products/dehydrocostus-lactone.html","C15H18O2","free base","N/A","C=C1CCC2C(OC(=O)C2=C)C3C1CCC3=C",3.282,2,0,0]
["S3630","Methyl Vanillate","e9","L6000-01","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.",182.17,"3943-74-6",{"v":36,"d":"36.00"},197.62,{"v":12,"d":"12.00"},65.87,"http://selleckchem.com/products/methyl-vanillate.html","C9H10O4","free base","N/A","COC(=O)C1=CC(=C(O)C=C1)OC",1.426,3,1,3]
["S3633","Pyrrolidinedithiocarbamate ammonium","f9","L6000-01","in 10mM DMSO","NF-κB","NF-κB","Pyrrolidinedithiocarbamate ammonium  (Ammonium pyrrolidine dithiocarbamate, APDC, PDTC) is a potent nuclear factor-κB (NF-κB) inhibitor that inhibits IκB phosphorylation, blocks NF-κB translocation to the nucleus and reduces the expression of downstream cytokines.",164.29,"5108-96-3",{"v":32,"d":"32.00"},194.78,{"v":32,"d":"32.00"},194.78,"http://selleckchem.com/products/pyrrolidinedithiocarbamate-ammoniumammonium.html","C5H9NS2.H3N","ammonium salt","APDC, PDTC, Pyrrolidine dithiocarbamic acid ammonium salt","N.SC(=S)N1CCCC1",2.172,0,0,1]
["S3692","N-Ethylmaleimide (NEM)","g9","L6000-01","in 10mM DMSO","Cysteine Protease,DUB","Proteases","N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria.",125.13,"128-53-0",{"v":25,"d":"25.00"},199.79,{"v":25,"d":"25.00"},199.79,"http://selleckchem.com/products/n-ethylmaleimide-nem.html","C6H7NO2","free base","N/A","CCN1C(=O)C=CC1=O",{"v":0.16,"d":"0.160"},2,0,1]
["S3842","Isoquercitrin","h9","L6000-01","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Isoquercitrin (Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside), a flavonoid compound with anticancer activity isolated from Bidens bipinnata L, is an inhibitor of Wnt/β-catenin that acts downstream of the β-catenin nuclear translocation.",464.38,"482-35-9",{"v":92,"d":"92.00"},198.11,"N/A","N/A","http://selleckchem.com/products/isoquercitrin.html","C21H20O12","free base","Hirsutrin, 3-Glucosylquercetin, Quercetin 3-o-glucopyranoside","OCC1OC(OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(O)C=C4)O)C(O)C(O)C1O",{"v":-0.3,"d":"-0.300"},4,8,4]
["S3867","(E)-Cardamonin","a10","L6000-01","in 10mM DMSO","NF-κB,TRP Channel","NF-κB","(E)-Cardamonin (Alpinetin chalcone, cardamomin) is a naturally occurring chalcone with strong anti-inflammatory activity. It is a novel TRPA1 antagonist with IC50 of 454 nM and also a NF-kB inhibitor.",270.28,"19309-14-9",{"v":54,"d":"54.00"},199.79,"N/A","N/A","http://selleckchem.com/products/e-cardamoni.html","C16H14O4","free base","Alpinetin chalcone, cardamomin","COC1=CC(=CC(=C1C(=O)\\C=C\\C2=CC=CC=C2)O)O",3.201,2,2,4]
["S3874","Curcumenol","b10","L6000-01","in 10mM DMSO","NF-κB,P450 (e.g. CYP17)","NF-κB","Curcumenol, a sesquiterpene isolated from Curcuma zedoaria, is known to possess a variety of health and medicinal values which includes neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. It inhibits NF-κB activation by suppressing the nuclear translocation of the NF-κB p65 subunit and blocking IκBα phosphorylation and degradation.",234.33,"19431-84-6",{"v":46,"d":"46.00"},{"v":196.3,"d":"196.30"},"N/A","N/A","http://selleckchem.com/products/curcumenol.html","C15H22O2","free base","N/A","CC1CCC2C(=CC3(O)OC12CC3=C(C)C)C",3.268,1,0,0]
["S4073","Sodium 4-Aminosalicylate","c10","L6000-01","in 10mM DMSO","NF-κB","NF-κB","Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.",211.15,"6018-19-5",{"v":42,"d":"42.00"},198.91,{"v":42,"d":"42.00"},198.91,"http://selleckchem.com/products/aminosalicylate-sodium.html","C7H7NO3.2H2O.Na","Sodium Salt","N/A","[Na+].NC1=CC(=C(C=C1)C([O-])=O)O",-1.003,0,2,1]
["S4712","Diethylmaleate","d10","L6000-01","in 10mM DMSO","NF-κB,Nrf2","NF-κB","Diethylmaleate (Diethyl ester, Maleic acid diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.",172.18,"141-05-9","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/diethylmaleate.html","C8H12O4","Free Base","Diethyl ester, Maleic acid diethyl ester","CCOC(=O)\\C=C/C(=O)OCC",1.187,4,0,6]
["S4902","QNZ (EVP4593)","e10","L6000-01","in 10mM DMSO","NF-κB,TNF-alpha","NF-κB","QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.",356.42,"545380-34-5",{"v":5,"d":"5.00"},14.03,"<1","N/A","http://selleckchem.com/products/qnz-evp4593.html","C22H20N4O","free base","N/A","NC1=CC2=C(NCCC3=CC=C(OC4=CC=CC=C4)C=C3)N=CN=C2C=C1",4.454,3,2,6]
["S4907","SC-514","f10","L6000-01","in 10mM DMSO","IκB/IKK","NF-κB","SC-514 (GK 01140) is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.",{"v":224.3,"d":"224.30"},"354812-17-2",{"v":45,"d":"45.00"},200.62,"<1","N/A","http://selleckchem.com/products/sc-514.html","C9H8N2OS2","free base","GK 01140","NC(=O)C1=C(N)C=C(S1)C2=CSC=C2",{"v":1.51,"d":"1.510"},1,2,2]
["S4920","b-AP15","g10","L6000-01","in 10mM DMSO","DUB","Ubiquitin","b-AP15 (NSC687852) is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.",419.39,"1009817-63-3",{"v":48,"d":"48.00"},114.45,"<1","N/A","http://selleckchem.com/products/b-ap15.html","C22H17N3O6","free base","NSC687852","[O-][N+](=O)C1=CC=C(C=C1)\\C=C2/CN(C\\C(=C/C3=CC=C(C=C3)[N+]([O-])=O)C2=O)C(=O)C=C",3.653,2,0,5]
["S4921","MNS (3,4-Methylenedioxy-β-nitrostyrene)","h10","L6000-01","in 10mM DMSO","p97,Src,Syk,Tyrosinase","Ubiquitin","MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.",193.16,"1485-00-3",{"v":39,"d":"39.00"},201.91,"<1","N/A","http://selleckchem.com/products/mdbn.html","C9H7NO4","free base","MDBN","[O-][N+](=O)/C=C/C1=CC2=C(OCO2)C=C1",1.578,2,0,2]
["S4937","4'-Hydroxychalcone","a11","L6000-01","in 10mM DMSO","NF-κB","NF-κB","4'-Hydroxychalcone (P-Cinnamoylphenol), found in herbs and spices and tea, is a member of the class of compounds known as retrochalcones. It has diverse biological activities, inhibiting TNFα-induced NF-κB pathway activation in a dose-dependent manner and activating BMP signaling.",224.25,"2657-25-2",{"v":44,"d":"44.00"},196.21,"N/A","N/A","http://selleckchem.com/products/hydroxychalcone.html","C15H12O2","free base","P-Cinnamoylphenol","OC1=CC=C(C=C1)C(=O)\\C=C\\C2=CC=CC=C2",{"v":3.46,"d":"3.460"},1,1,3]
["S5003","Tacrolimus (FK506)","b11","L6000-01","in 10mM DMSO","Autophagy,FKBP,phosphatase","PI3K/Akt/mTOR","Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.",804.02,"104987-11-3",{"v":94,"d":"94.00"},116.91,"<1","N/A","http://selleckchem.com/products/FK-506-(Tacrolimus).html","C44H69NO12","free base","FK506, FR900506, Fujimycin, Prograf","COC1CC(CCC1O)\\C=C(C)\\C2OC(=O)C3CCCCN3C(=O)C(=O)C4(O)OC(C(CC(C)C/C(=C/C(CC=C)C(=O)CC(O)C2C)C)OC)C(CC4C)OC",4.832,9,2,7]
["S5315","PRT4165","c11","L6000-01","in 10mM DMSO","BMI-1,E3 Ligase","Ubiquitin","PRT4165 is a Bmi1/Ring1A inhibitor with an IC50 of 3.9 µM in the cell-free assay and also inhibits PRC1-mediated H2A ubiquitylation in vivo and in vitro.",235.24,"31083-55-3",{"v":11,"d":"11.00"},46.76,"<1","N/A","http://selleckchem.com/products/prt4165.html","C15H9NO2","free base","N/A","O=C1C2=C(C=CC=C2)C(=O)C1=CC3=CC=CN=C3",2.085,3,0,1]
["S5815","WAY-316606","d11","L6000-01","in 10mM DMSO","SFRP,Wnt/beta-catenin","Stem Cells & Wnt","WAY-316606, a specific antagonist of SFRP1, functions as an activator of canonical Wnt/β-catenin signalling in the human hair bulb.",448.48,"915759-45-4",{"v":90,"d":"90.00"},200.68,{"v":1,"d":"1.00"},2.23,"http://www.selleckchem.com/products/way-316606.html","C18H19F3N2O4S2","Free Base","N/A","FC(F)(F)C1=CC=C(C=C1[S](=O)(=O)NC2CCNCC2)[S](=O)(=O)C3=CC=CC=C3",{"v":2.36,"d":"2.360"},4,2,6]
["S5841","DKM 2-93","e11","L6000-01","in 10mM DMSO","E1 Activating","Ubiquitin","DKM 2-93 is a relatively selective lead inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5).",243.69,"65836-72-8",{"v":49,"d":"49.00"},201.08,{"v":1,"d":"1.00"},{"v":4.1,"d":"4.10"},"http://www.selleckchem.com/products/dkm2-93.html","C11H14ClNO3","Free Base","N/A","COC1=CC=C(CNC(=O)CCl)C=C1OC",1.457,3,1,5]
["S7030","RG-7112","f11","L6000-01","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.",726.28,"939981-39-2",{"v":100,"d":"100.00"},137.69,"<1","N/A","http://selleckchem.com/products/rg-7112.html","C38H48Cl2N4O4S","free base","RO5045337","CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C)(C3=CC=C(Cl)C=C3)C(C)(N2C(=O)N4CCN(CCC[S](C)(=O)=O)CC4)C5=CC=C(Cl)C=C5",7.622,5,0,10]
["S7037","Wnt-C59 (C59)","g11","L6000-01","in 10mM DMSO","PORCN","Stem Cells & Wnt","Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells.",379.45,"1243243-89-1",{"v":76,"d":"76.00"},200.29,"<1","N/A","http://selleckchem.com/products/wnt-c59-c59.html","C25H21N3O","free base","N/A","CC1=NC=CC(=C1)C2=CC=C(CC(=O)NC3=CC=C(C=C3)C4=CC=CN=C4)C=C2",3.667,3,1,5]
["S7038","Epoxomicin (BU-4061T)","h11","L6000-01","in 10mM DMSO","Apoptosis related,Proteasome","Proteases","Epoxomicin (BU-4061T, Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited at 100- and 1000-fold reduced rate. Epoxomicin promotes apoptosis.",554.72,"134381-21-8",{"v":100,"d":"100.00"},180.27,"<1","N/A","http://selleckchem.com/products/epoxomicin-bu-4061t.html","C28H50N4O7","free base","Aids010837","CCC(C)C(NC(=O)C(C(C)CC)N(C)C(C)=O)C(=O)NC(=O)C(NC(CC(C)C)C(=O)C1(C)CO1)C(C)O",1.793,6,4,16]
["S7049","Oprozomib (ONX 0912)","a2","L6000-02","in 10mM DMSO","Proteasome","Proteases","Oprozomib (ONX 0912, PR-047) is an orally bioavailable inhibitor for CT-L activity of 20S proteasome β5/LMP7 with IC50 of 36 nM/82 nM. Phase 1/2.",532.61,"935888-69-0",{"v":100,"d":"100.00"},187.75,"<1","N/A","http://selleckchem.com/products/oprozomib-onx-0912.html","C25H32N4O7S","free base","PR-047","COCC(NC(=O)C(COC)NC(=O)C1=CN=C(C)S1)C(=O)NC(CC2=CC=CC=C2)C(=O)C3(C)CO3",-0.202,8,3,14]
["S7086","IWR-1-endo","b2","L6000-02","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","IWR-1-endo (endo-IWR 1, IWR-1) is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.",409.44,"1127442-82-3",{"v":21,"d":"21.00"},51.29,"<1","N/A","http://selleckchem.com/products/iwr-1-endo.html","C25H19N3O3","free base","endo-IWR 1, IWR-1","CC12C3CC(C=C3)C1C(=O)N(C2=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6",3.075,4,1,3]
["S7091","Zotarolimus (ABT-578)","c2","L6000-02","in 10mM DMSO","FKBP,mTOR","PI3K/Akt/mTOR","Zotarolimus (ABT-578,A 179578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM.",966.21,"221877-54-9",{"v":100,"d":"100.00"},{"v":103.5,"d":"103.50"},"<1","N/A","http://selleckchem.com/products/zotarolimus-abt-578.html","C52H79N5O12","free base","A 179578","COC1CC(CCC1[N]2C=NN=N2)CC(C)C3CC(=O)C(C)/C=C(C)/C(O)C(OC)C(=O)C(C)CC(C)/C=C/C=C/C=C(C)/C(CC4CCC(C)C(O)(O4)C(=O)C(=O)N5CCCCC5C(=O)O3)OC",5.793,13,1,7]
["S7096","KY02111","d2","L6000-02","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.",376.86,"1118807-13-8",{"v":75,"d":"75.00"},199.01,"<1","N/A","http://selleckchem.com/products/ky02111.html","C18H17ClN2O3S","free base","N/A","COC1=CC=C(CCC(=O)NC2=NC3=CC=C(Cl)C=C3S2)C=C1OC",4.362,4,1,6]
["S7129","PYR-41","e2","L6000-02","in 10mM DMSO","Apoptosis related,E1 Activating","Ubiquitin","PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2. PYR-41 induce apoptosis.",{"v":371.3,"d":"371.30"},"418805-02-4",{"v":74,"d":"74.00"},{"v":199.3,"d":"199.30"},"<1","N/A","http://selleckchem.com/products/pyr-41.html","C17H13N3O7","free base","N/A","CCOC(=O)C1=CC=C(C=C1)N2NC(=O)C(=C/C3=CC=C(O3)[N+]([O-])=O)/C2=O",{"v":1.87,"d":"1.870"},5,1,6]
["S7130","PR-619","f2","L6000-02","in 10mM DMSO","Autophagy,DUB","Ubiquitin","PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. PR-619 activates autophagy.",223.28,"2645-32-1",{"v":45,"d":"45.00"},201.54,"<1","N/A","http://selleckchem.com/products/pr-619.html","C7H5N5S2","free base","N/A","NC1=C(SC#N)C=C(SC#N)C(=N1)N",1.212,1,2,2]
["S7132","P5091 (P005091)","g2","L6000-02","in 10mM DMSO","DUB","Ubiquitin","P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47.",348.22,"882257-11-6",{"v":28,"d":"28.00"},80.41,"<1","N/A","http://selleckchem.com/products/p5091-p005091.html","C12H7Cl2NO3S2","free base","N/A","CC(=O)C1=CC(=C(S1)SC2=CC=CC(=C2Cl)Cl)[N+]([O-])=O",4.989,1,0,4]
["S7133","P22077","h2","L6000-02","in 10mM DMSO","DUB","Ubiquitin","P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47.",315.32,"1247819-59-5",{"v":63,"d":"63.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/p22077.html","C12H7F2NO3S2","free base","N/A","CC(=O)C1=CC(=C(S1)SC2=CC=C(F)C=C2F)[N+]([O-])=O",4.071,1,0,4]
["S7134","IU1","a3","L6000-02","in 10mM DMSO","Autophagy,DUB","Proteases","IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT. IU1 induces autophagy.",300.37,"314245-33-5",{"v":60,"d":"60.00"},199.75,"<1","N/A","http://selleckchem.com/products/iu1.html","C18H21FN2O","free base","N/A","CC1=CC(=C(C)[N]1C2=CC=C(F)C=C2)C(=O)CN3CCCC3",3.409,1,0,4]
["S7135","LDN-57444","b3","L6000-02","in 10mM DMSO","DUB","Proteases","LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.",397.64,"668467-91-2",{"v":11,"d":"11.00"},27.66,"<1","N/A","http://selleckchem.com/products/ldn-57444.html","C17H11Cl3N2O3","free base","N/A","CC(=O)O\\N=C/1C(=O)N(CC2=CC(=CC=C2Cl)Cl)C3=CC=C(Cl)C=C13",4.343,4,0,4]
["S7140","TCID","c3","L6000-02","in 10mM DMSO","DUB","Ubiquitin","TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.",283.92,"30675-13-9",{"v":23,"d":"23.00"},81.01,"<1","N/A","http://selleckchem.com/products/tcid.html","C9H2Cl4O2","free base","N/A","ClC1=C(Cl)C(=C2C(=O)CC(=O)C2=C1Cl)Cl",3.982,2,0,0]
["S7142","NSC697923","d3","L6000-02","in 10mM DMSO","E2 conjugating","Ubiquitin","NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A.",267.26,"343351-67-7",{"v":53,"d":"53.00"},198.31,"<1","N/A","http://selleckchem.com/products/nsc697923.html","C11H9NO5S","free base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)C2=CC=C(O2)[N+]([O-])=O",2.665,3,0,3]
["S7143","LGK-974","e3","L6000-02","in 10mM DMSO","PORCN","Stem Cells & Wnt","LGK-974 (NVP-LGK974, WNT974) is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM in TM3 cells. Phase 1.",396.44,"1243244-14-5",{"v":79,"d":"79.00"},199.27,"<1","N/A","http://selleckchem.com/products/lgk-974.html","C23H20N6O","free base","NVP-LGK974, WNT974","CC1=CC(=CC=N1)C2=C(C)C=C(CC(=O)NC3=CC=C(C=N3)C4=CN=CC=N4)C=N2",2.098,6,1,5]
["S7199","DBeQ","f3","L6000-02","in 10mM DMSO","p97","Ubiquitin","DBeQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.",340.42,"177355-84-9",{"v":68,"d":"68.00"},199.75,"<1","N/A","http://selleckchem.com/products/dbeq.html","C22H20N4","free base","JRF 12","C(NC1=NC2=CC=CC=C2C(=N1)NCC3=CC=CC=C3)C4=CC=CC=C4",5.232,2,2,6]
["S7205","Idasanutlin (RG-7388)","g3","L6000-02","in 10mM DMSO","MDM2/MDMX","Apoptosis","Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity.",616.48,"1229705-06-9",{"v":100,"d":"100.00"},162.21,"<1","N/A","http://selleckchem.com/products/idasanutlin-rg-7388.html","C31H29Cl2F2N3O4","free base","N/A","COC1=C(NC(=O)C2NC(CC(C)(C)C)C(C#N)(C2C3=C(F)C(=CC=C3)Cl)C4=CC=C(Cl)C=C4F)C=CC(=C1)C(O)=O",{"v":3.85,"d":"3.850"},3,2,8]
["S7273","SC75741","h3","L6000-02","in 10mM DMSO","Influenza Virus,NF-κB","NF-κB","SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. SC75741 efficiently blocks influenza virus propagation.",565.67,"913822-46-5",{"v":35,"d":"35.00"},61.87,"<1","N/A","http://selleckchem.com/products/sc75741.html","C29H23N7O2S2","free base","N/A","O=C(NC1=NC2=CC=C(C=C2[NH]1)C(=O)C3=CC=CC=C3)C4=CSC(=N4)C5CCN(CC5)C6=C7SC=CC7=NC=N6",{"v":5.57,"d":"5.570"},6,2,6]
["S7285","NMS-873","a4","L6000-02","in 10mM DMSO","p97","Ubiquitin","NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).",520.67,"1418013-75-8",{"v":100,"d":"100.00"},192.06,"<1","N/A","http://selleckchem.com/products/nms-873.html","C27H28N4O3S2","free base","N/A","CC1=CC(=CC=C1C2=CC=C(C=C2)[S](C)(=O)=O)OCC3=NN=C(SC4CCCC4)[N]3C5=CN=CC=C5",5.602,6,0,8]
["S7301","IWP-L6","b4","L6000-02","in 10mM DMSO","PORCN","Stem Cells & Wnt","IWP-L6 (Porcn Inhibitor III) is a highly potent Porcn inhibitor with EC50 of 0.5 nM.",472.58,"1427782-89-5",{"v":25,"d":"25.00"},{"v":52.9,"d":"52.90"},"<1","N/A","http://selleckchem.com/products/iwp-l6.html","C25H20N4O2S2","free base","Porcn Inhibitor III","O=C(CSC1=NC2=C(SCC2)C(=O)N1C3=CC=CC=C3)NC4=NC=C(C=C4)C5=CC=CC=C5",4.072,4,1,6]
["S7351","JSH-23","c4","L6000-02","in 10mM DMSO","NF-κB","NF-κB","JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.",240.34,"749886-87-1",{"v":48,"d":"48.00"},199.72,"<1","N/A","http://selleckchem.com/products/jsh-23.html","C16H20N2","free base","N/A","CC1=CC=C(NCCCC2=CC=CC=C2)C(=C1)N",3.739,0,2,5]
["S7352","Bay 11-7085","d4","L6000-02","in 10mM DMSO","IκB/IKK","NF-κB","BAY 11-7085 (Bay 11-7083) is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM.",249.33,"196309-76-9",{"v":50,"d":"50.00"},200.54,"<1","N/A","http://selleckchem.com/products/bay-11-7085.html","C13H15NO2S","free base","Bay 11-7083","CC(C)(C)C1=CC=C(C=C1)[S](=O)(=O)\\C=C\\C#N",2.635,2,0,3]
["S7386","MG-101 (ALLN)","e4","L6000-02","in 10mM DMSO","Cysteine Protease","Proteases","MG-101 (ALLN, Calpain inhibitor-1, Ac-LLnL-CHO) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.",383.53,"110044-82-1",{"v":76,"d":"76.00"},198.16,"<1","N/A","http://selleckchem.com/products/mg-101-alln.html","C20H37N3O4","Oxalate","Calpain inhibitor-1, Ac-LLnL-CHO","CCCCC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(C)=O)C=O",2.348,4,3,13]
["S7396","Calpeptin","f4","L6000-02","in 10mM DMSO","Apoptosis related,Cysteine Protease","Proteases","Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Calpeptin attenuates apoptosis and intracellular inflammatory changes in muscle cells.",362.46,"117591-20-5",{"v":72,"d":"72.00"},198.64,"<1","N/A","http://selleckchem.com/products/calpeptin.html","C20H30N2O4","free base","N/A","CCCCC(NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1)C=O",{"v":3.8,"d":"3.800"},4,2,12]
["S7414","Caffeic Acid Phenethyl Ester","g4","L6000-02","in 10mM DMSO","NF-κB","NF-κB","Caffeic acid phenethyl ester (CAPE, Phenylethyl Caffeate) is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.",284.31,"104594-70-9",{"v":57,"d":"57.00"},200.49,"<1","N/A","http://selleckchem.com/products/caffeic-acid-phenethyl-ester.html","C17H16O4","free base","CAPE, Phenylethyl Caffeate","OC1=CC=C(/C=C/C(=O)OCCC2=CC=CC=C2)C=C1O",3.573,2,2,6]
["S7424","PD 151746","h4","L6000-02","in 10mM DMSO","Cysteine Protease","Proteases","PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain.",237.25,"179461-52-0",{"v":47,"d":"47.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/pd-151746.html","C11H8FNO2S","free base","N/A","OC(=O)C(/S)=C/C1=C[NH]C2=CC=C(F)C=C12",{"v":2.49,"d":"2.490"},1,1,2]
["S7441","WS3","a5","L6000-02","in 10mM DMSO","IκB/IKK","NF-κB","WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.",569.58,"1421227-52-2",{"v":100,"d":"100.00"},175.57,"<1","N/A","http://selleckchem.com/products/ws3.html","C28H30F3N7O3","free base","N/A","CN1CCN(CC1)CC2=C(C=C(NC(=O)NC3=CC=C(OC4=CC(=NC=N4)NC(=O)C5CC5)C=C3)C=C2)C(F)(F)F",4.234,5,3,9]
["S7442","WS6","b5","L6000-02","in 10mM DMSO","IκB/IKK","NF-κB","WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.",568.59,"1421227-53-3",{"v":100,"d":"100.00"},175.87,"<1","N/A","http://selleckchem.com/products/ws6.html","C29H31F3N6O3","free base","N/A","CN1CCN(CC1)CC2=C(C=C(NC(=O)CC3=CC=C(OC4=CC(=NC=N4)NC(=O)C5CC5)C=C3)C=C2)C(F)(F)F",{"v":4.36,"d":"4.360"},5,2,10]
["S7462","PI-1840","c5","L6000-02","in 10mM DMSO","Proteasome","Proteases","PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor with IC50 of 27 nM with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).",394.47,"1401223-22-0",{"v":78,"d":"78.00"},197.73,"<1","N/A","http://selleckchem.com/products/pi-1840.html","C22H26N4O3","free base","N/A","CCCC1=CC=C(OCC(=O)N(CC2=NC(=NO2)C3=CC=CN=C3)C(C)C)C=C1",{"v":3.22,"d":"3.220"},6,0,9]
["S7484","FH535","d5","L6000-02","in 10mM DMSO","PPAR,Wnt/beta-catenin","Stem Cells & Wnt","FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.",{"v":361.2,"d":"361.20"},"108409-83-2",{"v":72,"d":"72.00"},199.34,"<1","N/A","http://selleckchem.com/products/fh535.html","C13H10Cl2N2O4S","free base","N/A","CC1=C(N[S](=O)(=O)C2=C(Cl)C=CC(=C2)Cl)C=CC(=C1)[N+]([O-])=O",4.027,2,1,4]
["S7489","YH239-EE","e5","L6000-02","in 10mM DMSO","MDM2/MDMX","Apoptosis","YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.",504.41,"1364488-67-4",{"v":100,"d":"100.00"},198.25,"<1","N/A","http://selleckchem.com/products/yh239-ee.html","C25H27Cl2N3O4","free base","N/A","CCOC(=O)C1=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(=O)NC(C)(C)C)C3=C([NH]1)C=C(Cl)C=C3",4.912,4,2,9]
["S7490","WIKI4","f5","L6000-02","in 10mM DMSO","PARP,Wnt/beta-catenin","DNA Damage/DNA Repair","WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling.",521.59,"838818-26-1",{"v":7,"d":"7.00"},13.42,"<1","N/A","http://selleckchem.com/products/wiki4.html","C29H23N5O3S","free base","N/A","COC1=CC=C(C=C1)[N]2C(=NN=C2C3=CC=NC=C3)SCCCN4C(=O)C5=CC=CC6=C5C(=CC=C6)C4=O",4.469,6,0,8]
["S7529","ML323","g5","L6000-02","in 10mM DMSO","DUB","Ubiquitin","ML323 displays reversible, nanomolar inhibitory activity and excellent selectivity toward USP1/UAF1 with IC50 of 76 nM.",384.48,"1572414-83-5",{"v":76,"d":"76.00"},197.67,"<1","N/A","http://selleckchem.com/products/ml323.html","C23H24N6","free base","N/A","CC(C)C1=C(C=CC=C1)C2=NC(=C(C)C=N2)NCC3=CC=C(C=C3)[N]4C=CN=N4",5.042,4,1,6]
["S7646","Voxtalisib (XL765)","h5","L6000-02","in 10mM DMSO","mTOR,PI3K","Angiogenesis","Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.",270.29,"934493-76-2",{"v":54,"d":"54.00"},199.79,"<1","N/A","http://selleckchem.com/products/voxtalisib-xl765-sar245409.html","C13H14N6O","free base","SAR245409","CCN1C(=O)C(=CC2=C(C)N=C(N)N=C12)C3=CC=N[NH]3",0.838,4,2,2]
["S7649","MI-773 (SAR405838)","a6","L6000-02","in 10mM DMSO","MDM2/MDMX,p53","Apoptosis","MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.",{"v":562.5,"d":"562.50"},"1303607-60-4",{"v":100,"d":"100.00"},177.78,"<1","N/A","http://selleckchem.com/products/mi-773-sar405838.html","C29H34Cl2FN3O3","free base","N/A","CC(C)(C)CC1NC(C(C2=CC=CC(=C2F)Cl)C13C(=O)NC4=C3C=CC(=C4)Cl)C(=O)NC5CCC(O)CC5",4.856,2,4,5]
["S7672","Omaveloxolone (RTA-408)","b6","L6000-02","in 10mM DMSO","NF-κB,Nrf2","NF-κB","Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.",554.71,"1474034-05-3",{"v":100,"d":"100.00"},180.27,"<1","N/A","http://selleckchem.com/products/omaveloxolone-rta-408.html","C33H44F2N2O3","free base","N/A","CC1(C)CCC2(CCC3(C)C(C2C1)C(=O)C=C4C3(C)CCC5C(C)(C)C(=O)C(=CC45C)C#N)NC(=O)C(C)(F)F",5.339,3,1,2]
["S7691","PS-1145","c6","L6000-02","in 10mM DMSO","IκB/IKK","NF-κB","PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.",322.75,"431898-65-6",{"v":64,"d":"64.00"},{"v":198.3,"d":"198.30"},"<1","N/A","http://selleckchem.com/products/ps-1145.html","C17H11ClN4O","free base","N/A","ClC1=CC(=C2[NH]C3=C(C=CN=C3)C2=C1)NC(=O)C4=CN=CC=C4",2.471,3,2,2]
["S7697","LY2409881","d6","L6000-02","in 10mM DMSO","IκB/IKK","NF-κB","LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases.",594.43,"946518-60-1",{"v":20,"d":"20.00"},33.65,"<1","N/A","http://selleckchem.com/products/ly2409881.html","C24H32Cl4N6OS","trihydrochloride","N/A","Cl.Cl.Cl.CN1CCN(CCCNC2=NC=C(Cl)C(=N2)C3=CC4=C(S3)C=CC=C4C(=O)NC5CC5)CC1",5.147,3,2,8]
["S7811","MHY1485","e6","L6000-02","in 10mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","MHY1485 is a potent, and cell-permeable mTOR activator, and also potently inhibits autophagy.",387.39,"326914-06-1",{"v":4,"d":"4.00"},10.33,"<1","N/A","http://selleckchem.com/products/mhy1485.html","C17H21N7O4","free base","N/A","[O-][N+](=O)C1=CC=C(NC2=NC(=NC(=N2)N3CCOCC3)N4CCOCC4)C=C1",2.653,5,1,5]
["S7851","AZD3264","f6","L6000-02","in 10mM DMSO","IκB/IKK","NF-κB","AZD3264 is a novel IKK2 inhibitor.",{"v":441.5,"d":"441.50"},"1609281-86-8",{"v":88,"d":"88.00"},199.32,"<1","N/A","http://selleckchem.com/products/azd3264.html","C21H23N5O4S","free base","N/A","CC1=C(C(=NO1)C)C2=CC(=C(C=C2)C3=CC(=C(NC(N)=O)S3)C(N)=O)OC4CCNC4",1.235,5,4,6]
["S7875","NVP-CGM097","g6","L6000-02","in 10mM DMSO","MDM2/MDMX","Apoptosis","NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3 nM for hMDM2 in TR-FRET assay. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway.",659.26,"1313363-54-0",{"v":65,"d":"65.00"},{"v":98.6,"d":"98.60"},"<1","N/A","http://selleckchem.com/products/nvp-cgm097.html","C38H47ClN4O4","free base","CGM-097","COC1=CC2=C(C=C1OC(C)C)C(N(C(=O)C2)C3=CC=C(C=C3)N(C)CC4CCC(CC4)N5CCN(C)C(=O)C5)C6=CC=C(Cl)C=C6",6.455,4,0,9]
["S7886","Onatasertib (CC 223)","h6","L6000-02","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","Onatasertib (CC 223) is a potent, selective, and orally bioavailable mTOR inhibitor with IC50 of 16 nM, >200-fold selectivity over the related PI3K-α. Phase 1/2.",397.47,"1228013-30-6",{"v":79,"d":"79.00"},198.76,"<1","N/A","http://selleckchem.com/products/cc-223.html","C21H27N5O3","free base","ATG-008","COC1CCC(CC1)N2C(=O)CNC3=NC=C(N=C23)C4=CN=C(C=C4)C(C)(C)O",{"v":1.66,"d":"1.660"},5,1,4]
["S7888","Spautin-1","a7","L6000-02","in 10mM DMSO","Apoptosis related,Autophagy,DUB","Autophagy","Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. Spautin-1 enhances apoptosis.",271.26,"1262888-28-7",{"v":54,"d":"54.00"},199.07,"<1","N/A","http://selleckchem.com/products/spautin-1.html","C15H11F2N3","free base","N/A","FC1=CC=C(CNC2=NC=NC3=CC=C(F)C=C23)C=C1",{"v":3.73,"d":"3.730"},2,1,3]
["S7891","CC-115","b7","L6000-02","in 10mM DMSO","DNA-PK,mTOR","DNA Damage/DNA Repair","CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) with IC50 values of 0.013 μM and 0.021 μM, respectively. It has potential antineoplastic activity.",336.35,"1228013-15-7",{"v":67,"d":"67.00"},{"v":199.2,"d":"199.20"},"<1","N/A","http://selleckchem.com/products/cc-115.html","C16H16N8O","free base","N/A","CCN1C(=O)CNC2=NC=C(N=C12)C3=C(C)N=C(C=C3)C4=N[NH]C=N4",0.664,6,2,3]
["S7892","Avadomide (CC-122)","c7","L6000-02","in 10mM DMSO","E3 Ligase ,Immunology & Inflammation related","Ubiquitin","Avadomide (CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4CRBN.",286.29,"1015474-32-4",{"v":57,"d":"57.00"},{"v":199.1,"d":"199.10"},"<1","N/A","http://selleckchem.com/products/cc-122.html","C14H14N4O3","Free Base","N/A","CC1=NC2=CC=CC(=C2C(=O)N1C3CCC(=O)NC3=O)N",-0.477,4,2,1]
["S7933","VR23","d7","L6000-02","in 10mM DMSO","Proteasome","Proteases","VR23 is a potent proteasome inhibitor with IC50 of 1 nM, 50-100 nM, and 3 μM for trypsin-like proteasomes, chymotrypsin-like proteasomes, and caspase-like proteasomes, respectively.",477.88,"1624602-30-7",{"v":31,"d":"31.00"},64.87,"<1","N/A","http://selleckchem.com/products/vr23.html","C19H16ClN5O6S","free base","N/A","[O-][N+](=O)C1=CC=C(C(=C1)[N+]([O-])=O)[S](=O)(=O)N2CCN(CC2)C3=CC=NC4=CC(=CC=C34)Cl",3.215,3,0,5]
["S7948","MRT67307 HCl","e7","L6000-02","in 10mM DMSO","Autophagy,IκB/IKK,TBK1,ULK","NF-κB","MRT67307 is a potent and dual IKKϵ and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy.","464.6 (free-base)","1781882-89-0",{"v":92,"d":"92.00"},198.02,{"v":92,"d":"92.00"},198.02,"https://www.selleckchem.com/products/mrt67307-hcl.html","C26H36N6O2.xHCl","hydrochloride","N/A","O=C(NCCCNC1=NC(=NC=C1C2CC2)NC3=CC(=CC=C3)CN4CCOCC4)C5CCC5",4.257,4,3,11]
["S7954","CP21R7 (CP21)","f7","L6000-02","in 10mM DMSO","GSK-3,Wnt/beta-catenin","Stem Cells & Wnt","CP21R7 (CP21) is a potent and selective GSK-3β inhibitor that can potently activate canonical Wnt signalling.",317.34,"125314-13-8",{"v":63,"d":"63.00"},198.53,"<1","N/A","http://selleckchem.com/products/cp21r7-cp21.html","C19H15N3O2","free base","N/A","C[N]1C=C(C2=C1C=CC=C2)C3=C(C(=O)NC3=O)C4=CC=CC(=C4)N",2.315,2,2,2]
["S8000","Tenovin-1","g7","L6000-02","in 10mM DMSO","Dehydrogenase,p53,Sirtuin","Apoptosis","Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).",369.48,"380315-80-0",{"v":74,"d":"74.00"},200.28,"<1","N/A","http://selleckchem.com/products/tenovin-1.html","C20H23N3O2S","free base","N/A","CC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1",4.287,2,3,6]
["S8040","GDC-0349","h7","L6000-02","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.",452.55,"1207360-89-1",{"v":91,"d":"91.00"},201.08,"<1","N/A","http://selleckchem.com/products/gdc-0349.html","C24H32N6O3","free base","RG-7603","CCNC(=O)NC1=CC=C(C=C1)C2=NC(=C3CCN(CC3=N2)C4COC4)N5CCOCC5C",1.982,5,2,5]
["S8044","BMS-345541","a8","L6000-02","in 10mM DMSO","IκB/IKK","NF-κB","BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM in cell-free assays, respectively.",255.32,"445430-58-0",{"v":9,"d":"9.00"},35.25,"<1","N/A","http://selleckchem.com/products/bms-345541.html","C14H17N5","free base","N/A","CC1=CC=C2N=C(NCCN)C3=NC=C(C)[N]3C2=C1",1.472,2,2,3]
["S8050","ETP-46464","b8","L6000-02","in 10mM DMSO","ATM/ATR,mTOR","PI3K/Akt/mTOR","ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.",470.52,"1345675-02-6",{"v":6,"d":"6.00"},12.75,"<1","N/A","http://selleckchem.com/products/etp-46464.html","C30H22N4O2","free base","N/A","CC(C)(C#N)C1=CC=C(C=C1)N2C(=O)OCC3=C2C4=C(C=CC(=C4)C5=CN=C6C=CC=CC6=C5)N=C3",5.813,4,0,3]
["S8065","Nutlin-3b","c8","L6000-02","in 10mM DMSO","MDM2/MDMX","Apoptosis","Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.",581.49,"675576-97-3",{"v":100,"d":"100.00"},171.97,"<1","N/A","http://selleckchem.com/products/nutlin-3b.html","C30H30Cl2N4O4","free base","(+)-Nutlin-3","COC1=CC=C(C(=C1)OC(C)C)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(Cl)C=C4)C5=CC=C(Cl)C=C5",5.434,5,1,6]
["S8078","Bardoxolone Methyl","d8","L6000-02","in 10mM DMSO","Apoptosis related,Autophagy,Ferroptosis,IκB/IKK,NF-κB,Nrf2","NF-κB","Bardoxolone Methyl (RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me) is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. Bardoxolone Methyl abrogates ferroptosis. Bardoxolone methyl induces apoptosis and autophagy in cancer cells.",505.69,"218600-53-4",{"v":21,"d":"21.00"},41.53,"<1","N/A","http://selleckchem.com/products/bardoxolone-methyl.html","C32H43NO4","free base","RTA 402, TP-155, NSC 713200, CDDO Methyl Ester, CDDO-Me","COC(=O)C12CCC(C)(C)CC1C3C(=O)C=C4C(C)(CCC5C(C)(C)C(=O)C(=CC45C)C#N)C3(C)CC2",5.798,4,0,2]
["S8101","CB-5083","e8","L6000-02","in 10mM DMSO","ATPase,p97","Transmembrane Transporters","CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.",413.47,"1542705-92-9",{"v":82,"d":"82.00"},198.32,"<1","N/A","http://selleckchem.com/products/cb-5083.html","C24H23N5O2","free base","N/A","CC1=CC2=C(C=CC=C2C(N)=O)[N]1C3=NC4=C(COCC4)C(=N3)NCC5=CC=CC=C5",3.748,4,2,5]
["S8163","Paxalisib (GDC-0084)","f8","L6000-02","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Paxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor of PI3K and mTOR with Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.",382.42,"1382979-44-3",{"v":8,"d":"8.00"},20.92,"<1","N/A","http://selleckchem.com/products/gdc-0084.html","C18H22N8O2","free base","RG7666","CC1(C)OCC[N]2C3=C(N=C12)C(=NC(=N3)C4=CN=C(N)N=C4)N5CCOCC5",0.588,7,1,2]
["S8177","BH3I-1","g8","L6000-02","in 10mM DMSO","Bcl-2","Apoptosis","BH3I-1 is a Bcl-XL-BH3 domain interaction inhibitor with Ki of 2.4 μM (by fluorescence polarization ).It is a selective inhibitor of Bcl-2 family proteins.",400.31,"300817-68-9",{"v":64,"d":"64.00"},159.88,"<1","N/A","http://selleckchem.com/products/bh3i-1.html","C15H14BrNO3S2","free base","N/A","CC(C)C(N1C(=S)S\\C(=C/C2=CC=C(Br)C=C2)C1=O)C(O)=O",4.604,2,0,4]
["S8178","Wnt agonist 1","h8","L6000-02","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Wnt agonist 1 (BML-284 HCL, AMBMP HCL) is a cell permeable Wnt signaling pathway activator, which induces β-catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 μM.",386.83,"2095432-75-8",{"v":77,"d":"77.00"},199.05,"<1","N/A","http://selleckchem.com/products/wnt-agonist-1.html","C19H18N4O3.HCl","hydrochloride","BML-284 HCL, BML-284 hydrochloride, AMBMP hydrochloride, AMBMP HCL","Cl.COC1=CC(=CC=C1)C2=NC(=NC(=C2)NCC3=CC=C4OCOC4=C3)N",3.837,5,2,5]
["S8248","IQ-1","a9","L6000-02","in 10mM DMSO","PP2A,Wnt/beta-catenin","Stem Cells & Wnt","IQ-1 enables Wnt/β-catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation, Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction.",362.42,"331001-62-8",{"v":72,"d":"72.00"},198.66,"<1","N/A","http://selleckchem.com/products/iq-1.html","C21H22N4O2","free base","N/A","CC(=O)C1=CC=C(C=C1)N=N\\C(C(N)=O)=C2\\NC(C)(C)CC3=C2C=CC=C3",3.005,4,2,4]
["S8261","GSK583","b9","L6000-02","in 10mM DMSO","Interleukins,RIP kinase,TNF-alpha","Apoptosis","GSK583 is a highly potent and selective inhibitor of RIP2 kinase with IC50 of 5 nM. GSK583 also inhibits both TNF-α and IL-6 production with IC50 of ~200 nM in explant cultures.",398.45,"1346547-00-9",{"v":79,"d":"79.00"},198.27,"<1","N/A","http://selleckchem.com/products/gsk583.html","C20H19FN4O2S","free base","N/A","CC(C)(C)[S](=O)(=O)C1=CC=C2N=CC=C(NC3=N[NH]C4=C3C=C(F)C=C4)C2=C1",4.412,4,2,4]
["S8279","(±)-Shikonin","c9","L6000-02","in 10mM DMSO","Anti-infection,Chloride Channel,COVID-19,NF-κB,PKM,Proteasome,TNF-alpha","Metabolism","(±)-Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844), a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.",{"v":288.3,"d":"288.30"},"54952-43-1",{"v":57,"d":"57.00"},197.71,"<1","N/A","http://selleckchem.com/products/shikonin.html","C16H16O5","free base","Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844","CC(C)=CCC(O)C1=CC(=O)C2=C(O)C=CC(=C2C1=O)O",2.444,2,3,3]
["S8288","VLX1570","d9","L6000-02","in 10mM DMSO","DUB","Ubiquitin","VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro.",469.39,"1431280-51-1",{"v":93,"d":"93.00"},198.13,"<1","N/A","http://selleckchem.com/products/vlx1570.html","C23H17F2N3O6","free base","N/A","[O-][N+](=O)C1=C(F)C=CC(=C1)\\C=C2/CCN(C\\C(=C/C3=CC=C(F)C(=C3)[N+]([O-])=O)C2=O)C(=O)C=C",4.385,2,0,5]
["S8298","CZ415","e9","L6000-02","in 10mM DMSO","mTOR","PI3K/Akt/mTOR","CZ415, a potent ATP-competitive mTOR inhibitor with very good cell permeability.",459.56,"1429639-50-8",{"v":91,"d":"91.00"},198.02,"<1","N/A","http://selleckchem.com/products/cz415.html","C22H29N5O4S","free base","N/A","CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C[S](=O)(=O)C3(C)C)C(=N2)N4CCOCC4C",{"v":2.2,"d":"2.200"},6,2,4]
["S8317","3BDO","f9","L6000-02","in 10mM DMSO","Apoptosis related,Autophagy,FKBP,mTOR","PI3K/Akt/mTOR","3BDO, a butyrolactone derivative, could target FKBP1A and activate the mTOR signaling pathway. It inhibits autophagy in HUVECs. 3BDO inhibits oxLDL-induced apoptosis.",327.33,"890405-51-3",{"v":65,"d":"65.00"},198.58,"<1","N/A","http://selleckchem.com/products/3bdo.html","C18H17NO5","free base","3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one","[O-][N+](=O)C1=C(OCC2CC(CC3=CC=CC=C3)C(=O)O2)C=CC=C1",3.782,3,0,6]
["S8320","SKL2001","g9","L6000-02","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","SKL2001 is a novel agonist of the Wnt/β-catenin pathway. It disrupts the Axin/β-catenin interaction.",286.29,"909089-13-0",{"v":57,"d":"57.00"},{"v":199.1,"d":"199.10"},"<1","N/A","http://selleckchem.com/products/skl2001.html","C14H14N4O3","free base","N/A","O=C(NCCC[N]1C=CN=C1)C2=NOC(=C2)C3=CC=CO3",0.929,5,1,6]
["S8322","Samotolisib (LY3023414)","h9","L6000-02","in 10mM DMSO","DNA-PK,mTOR,PI3K","PI3K/Akt/mTOR","Samotolisib (LY3023414, GTPL8918) is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK.",406.48,"1386874-06-1",{"v":47,"d":"47.00"},115.63,"<1","N/A","http://selleckchem.com/products/ly3023414.html","C23H26N4O3","free base","GTPL8918","COC(C)CN1C(=O)N(C)C2=C1C3=CC(=CC=C3N=C2)C4=CC(=CN=C4)C(C)(C)O",1.883,4,0,5]
["S8327","KYA1797K","a10","L6000-02","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay).",442.51,"1956356-56-1",{"v":29,"d":"29.00"},65.54,{"v":29,"d":"29.00"},65.54,"http://selleckchem.com/products/kya1797k.html","C17H11N2O6S2.K","potassium salt","N/A","[O-][N+](=O)C1=CC=C(C=C1)C2=CC=C(O2)\\C=C3/SC(=S)N(CCC(=O)O[K])C3=O",3.967,4,0,7]
["S8334","XMU-MP-1","b10","L6000-02","in 10mM DMSO","MST","Hippo","XMU-MP-1 is an inhibitor of MST1/2 with IC50 values of 71.1±12.9 nM and 38.1±6.9 nM against MST1 and MST2, respectively.",416.48,"2061980-01-4",{"v":83,"d":"83.00"},199.29,"<1","N/A","http://selleckchem.com/products/xmu-mp-1.html","C17H16N6O3S2","free base","N/A","CN1C(=O)C2=C(C=CS2)N(C)C3=NC(=NC=C13)NC4=CC=C(C=C4)[S](N)(=O)=O",2.236,5,2,3]
["S8403","MX69","c10","L6000-02","in 10mM DMSO","MDM2/MDMX","Apoptosis","MX69 is a MDM2/XIAP inhibitor that binds to MDM2 RING protein with binding Kd values of 2.34 μM. It is used for cancer treatment.",474.57,"1005264-47-0",{"v":95,"d":"95.00"},200.18,"<1","N/A","http://selleckchem.com/products/mx69.html","C27H26N2O4S","free base","N/A","CC1=C(C)C=C(N[S](=O)(=O)C2=CC3=C(NC(C4CC=CC34)C5=CC=C(C=C5)C(O)=O)C=C2)C=C1",5.082,3,2,5]
["S8429","PNU-74654","d10","L6000-02","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","PNU-75654 disrupts the Wnt signaling pathway via inhibition of the interaction (KD50=450 nM) between β-catenin and Tcf4.",320.34,"113906-27-7",{"v":64,"d":"64.00"},199.79,"<1","N/A","http://selleckchem.com/products/pnu-74654.html","C19H16N2O3","free base","N/A","CC1=CC=C(O1)/C=N/NC(=O)C2=CC=CC=C2OC3=CC=CC=C3",3.784,4,1,5]
["S8474","LF3","e10","L6000-02","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM.",416.56,"664969-54-4",{"v":83,"d":"83.00"},199.25,"<1","N/A","http://selleckchem.com/products/lf3.html","C20H24N4O2S2","free base","N/A","N[S](=O)(=O)C1=CC=C(NC(=S)N2CCN(CC2)C\\C=C\\C3=CC=CC=C3)C=C1",3.762,2,2,7]
["S8483","CBL0137 HCl","f10","L6000-02","in 10mM DMSO","NF-κB,p53","Apoptosis","CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).",372.89,"1197397-89-9",{"v":38,"d":"38.00"},101.91,{"v":24,"d":"24.00"},64.36,"http://selleckchem.com/products/cbl0137-cbl-0137.html","C21H24N2O2.HCl","HCl","CBLC137 HCl, Curaxin 137 HCl","Cl.CC(C)NCC[N]1C2=C(C=C(C=C2)C(C)=O)C3=C1C=CC(=C3)C(C)=O",{"v":3.72,"d":"3.720"},2,1,6]
["S8484","GSK2982772","g10","L6000-02","in 10mM DMSO","RIP kinase,TNF-alpha","Apoptosis","GSK2982772 is an ATP competitive receptor-interacting protein-1 (RIP1) kinase (RIPK1) inhibitor with the IC50 value of 16 nM. It has exquisite kinase specificity and excellent activity in blocking many TNF-dependent cellular responses.",{"v":377.4,"d":"377.40"},"1622848-92-3",{"v":75,"d":"75.00"},198.73,"<1","N/A","http://selleckchem.com/products/gsk2982772.html","C20H19N5O3","free base","N/A","CN1C(=O)C(COC2=CC=CC=C12)NC(=O)C3=N[NH]C(=N3)CC4=CC=CC=C4",1.639,5,2,4]
["S8589","SF2523","h10","L6000-02","in 10mM DMSO","DNA-PK,Epigenetic Reader Domain,mTOR,PI3K","PI3K/Akt/mTOR","SF2523 is a highly selective and potent inhibitor of PI3K with IC50 values of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.",371.41,"1174428-47-7",{"v":29,"d":"29.00"},78.08,"<1","N/A","http://selleckchem.com/products/sf2523.html","C19H17NO5S","free base","N/A","O=C1C=C(OC2=C1SC=C2C3=CC=C4OCCOC4=C3)N5CCOCC5",3.081,5,0,2]
["S8642","GSK'963","a11","L6000-02","in 10mM DMSO","RIP kinase","Apoptosis","GSK'963 is a chiral small-molecule inhibitor of RIP1 kinase (RIPK1) with an IC50 of 29 nM in FP binding assays. It is >10 000-fold selective for RIP1 over 339 other kinases.",230.31,"2049868-46-2",{"v":46,"d":"46.00"},199.73,"<1","N/A","http://selleckchem.com/products/gsk963.html","C14H18N2O","free base","N/A","CC(C)(C)C(=O)N1N=CCC1C2=CC=CC=C2",2.545,2,0,2]
["S8644","GNF-6231","b11","L6000-02","in 10mM DMSO","PORCN","Stem Cells & Wnt","GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.",448.49,"1243245-18-2",{"v":89,"d":"89.00"},198.44,"<1","N/A","http://selleckchem.com/products/gnf-6231.html","C24H25FN6O2","free base","N/A","CC(=O)N1CCN(CC1)C2=CC=C(NC(=O)CC3=CC(=C(N=C3)C4=CC(=NC=C4)F)C)N=C2",2.135,5,1,5]
["S8645","IWP-O1","c11","L6000-02","in 10mM DMSO","PORCN","Stem Cells & Wnt","IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.",432.48,"2074607-48-8",{"v":86,"d":"86.00"},198.85,"<1","N/A","http://selleckchem.com/products/iwp-O1.html","C26H20N6O","free base","N/A","O=C(C[N]1N=NC(=C1C2=CC=CC=C2)C3=CC=NC=C3)NC4=NC=C(C=C4)C5=CC=CC=C5",4.161,5,1,6]
["S8647","iCRT3","d11","L6000-02","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays.",394.53,"901751-47-1",{"v":78,"d":"78.00"},{"v":197.7,"d":"197.70"},"<1","N/A","http://selleckchem.com/products/icrt3.html","C23H26N2O2S","free base","N/A","CCC1=CC=C(C=C1)C2=NC(=C(C)O2)CSCC(=O)NCCC3=CC=CC=C3",4.468,3,1,9]
["S8652","Skp2 inhibitor C1 (SKPin C1)","e11","L6000-02","in 10mM DMSO","E3 Ligase","Ubiquitin","Skp2 inhibitor C1 (SKPin C1) is a specific and selective small-molecule inhibitor of Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.",465.34,"432001-69-9",{"v":93,"d":"93.00"},199.85,"<1","N/A","http://selleckchem.com/products/skp2-inhibitor-c1-skpin-c1.html","C18H13BrN2O4S2","free base/salt","N/A","OC(=O)COC1=C(C=C(Br)C=C1)\\C=C2/SC(=S)N(CC3=CN=CC=C3)C2=O",3.693,4,0,6]
["S8661","CA3 (CIL56)","f11","L6000-02","in 10mM DMSO","Ferroptosis,ROS,TEAD,YAP","Hippo","CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces ferroptosis and iron-dependent reactive oxygen species (ROS).",489.61,"300802-28-2",{"v":97,"d":"97.00"},198.12,"<1","N/A","http://selleckchem.com/products/ca3.html","C23H27N3O5S2","free base","N/A","O/N=C1/C2=CC(=CC=C2C3=C1C=C(C=C3)[S](=O)(=O)N4CCCCC4)[S](=O)(=O)N5CCCCC5",3.058,5,0,4]
["S8696","2-D08","g11","L6000-02","in 10mM DMSO","SUMO","Ubiquitin","2-D08 (2',3',4'-trihydroxy flavone) is a cell permeable, mechanistically unique inhibitor of protein sumoylation.",270.24,"144707-18-6",{"v":54,"d":"54.00"},199.82,"<1","N/A","http://selleckchem.com/products/2-d08.html","C15H10O5","free base","2',3',4'-trihydroxy flavone","OC1=CC=C(C(=C1O)O)C2=CC(=O)C3=CC=CC=C3O2",{"v":2.41,"d":"2.410"},2,3,1]
["S8738","Bimiralisib (PQR309)","h11","L6000-02","in 10mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Bimiralisib (PQR309) is a novel brain-penetrant dual PI3K/mTOR inhibitor with in vitro and in vivo antilymphoma activity. It displays excellent selectivity versus PI3K-related lipid kinases, protein kinases and unrelated targets.",411.38,"1225037-39-7",{"v":6,"d":"6.00"},14.59,"<1","N/A","http://www.selleckchem.com/products/pqr309-bimiralisib.html","C17H20F3N7O2","Free Base","N/A","NC1=NC=C(C2=NC(=NC(=N2)N3CCOCC3)N4CCOCC4)C(=C1)C(F)(F)F",1.891,6,1,4]
["S8760","Iberdomide (CC220)","a2","L6000-03","in 10mM DMSO","Apoptosis related,E3 Ligase ,E3 ligase Ligand,Immunology & Inflammation related","Immunology & Inflammation","Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Iberdomide (CC-220) induces apoptosis with antitumor and immunostimulatory activities.",{"v":449.5,"d":"449.50"},"1323403-33-3",{"v":90,"d":"90.00"},200.22,"<1","N/A","http://www.selleck.cn/products/iberdomide.html","C25H27N3O5","free base","N/A","O=C1CCC(N2CC3=C(OCC4=CC=C(CN5CCOCC5)C=C4)C=CC=C3C2=O)C(=O)N1",{"v":1.56,"d":"1.560"},5,1,6]
["S8761","Adavivint (SM04690)","b2","L6000-03","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Adavivint (SM04690,Lorecivivint) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ∼150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.",505.55,"1467093-03-3",{"v":30,"d":"30.00"},59.34,"<1","N/A","http://www.selleckchem.com/products/adavivint.html","C29H24FN7O","Free Base","Lorecivivint","CC(C)CC(=O)NC1=CN=CC(=C1)C2=CC3=C([NH]N=C3C4=NC5=C([NH]4)C(=CN=C5)C6=CC=CC(=C6)F)C=C2",4.779,5,3,6]
["S9042","Wedelolactone","c2","L6000-03","in 10mM DMSO","Caspase,IκB/IKK","NF-κB","Wedelolactone, a medicinal plant-derived natural compound, is an inhibitor of IKK that is critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. Wedelolactone is also an inhibitor of caspase-11.",314.25,"524-12-9",{"v":63,"d":"63.00"},200.48,"N/A","N/A","https://www.selleckchem.com/products/wedelolactone.html","C16H10O7","free base","FW73945","COC1=CC2=C(C(=C1)O)C3=C(C(=O)O2)C4=C(O3)C=C(O)C(=C4)O",2.803,4,3,1]
["S9106","Eleutheroside E","d2","L6000-03","in 10mM DMSO","Immunology & Inflammation related,NF-κB","NF-κB","Eleutheroside E, a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory effects by inhibiting NF-κB and protecting against myocardial infarction.",742.72,"39432-56-9",{"v":10,"d":"10.00"},13.46,"N/A","N/A","https://www.selleckchem.com/products/eleutheroside-e.html","C34H46O18","free base","N/A","COC1=C(OC2OC(CO)C(O)C(O)C2O)C(=CC(=C1)C3OCC4C3COC4C5=CC(=C(OC6OC(CO)C(O)C(O)C6O)C(=C5)OC)OC)OC",-1.709,10,8,12]
["S9432","Ginkgolic Acid","e2","L6000-03","in 10mM DMSO","Histone Acetyltransferase,SUMO","Ubiquitin","Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).",{"v":346.5,"d":"346.50"},"22910-60-7",{"v":69,"d":"69.00"},199.13,"N/A","N/A","https://www.selleckchem.com/products/ginkgolic-acid-s9432.html","C22H34O3","free base","N/A","CCCCCC\\C=C/CCCCCCCC1=CC=CC(=C1C(O)=O)O",7.646,1,1,14]
["S9445","Ginkgolic Acid (C13:0)","f2","L6000-03","in 10mM DMSO","Histone Acetyltransferase,SUMO","Ubiquitin","Ginkgolic Acid (C13:0) is a natural anticariogenic agent in Ginkgo biloba L. that exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity. Ginkgolic acid is a potent sumoylation inhibitor and reported to inhibit histone acetylation transferase (HAT).",320.47,"20261-38-5",{"v":64,"d":"64.00"},199.71,"N/A","N/A","https://www.selleckchem.com/products/ginkgolic-acid-s9445.html","C20H32O3","free base","N/A","CCCCCCCCCCCCCC1=CC=CC(=C1C(O)=O)O",7.178,1,1,13]
["S6748","ML364","g2","L6000-03","in 10mM DMSO","DUB","Ubiquitin","ML364 is a small molecule inhibitor of the deubiquitinase USP2 with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate.",517.54,"1991986-30-1",{"v":50,"d":"50.00"},96.61,"<1","N/A","http://www.selleck.cn/products/ml364.html","C24H18F3N3O3S2","Free Base","N/A","CC1=CC=C(C=C1)[S](=O)(=O)NC2=CC(=CC=C2C(=O)NC3=NC(=CS3)C4=CC=CC=C4)C(F)(F)F",5.475,4,2,7]
["S9416","Triptonide","h2","L6000-03","in 10mM DMSO","Wnt/beta-catenin","Stem Cells & Wnt","Triptonide, isolated from the roots of Tripterygium wilfordii, can effectively inhibit canonical Wnt/β-catenin signaling by targeting the downstream C-terminal transcription domain of β-catenin or a nuclear component associated with β-catenin. It is also an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent.",358.39,"38647-11-9",{"v":71,"d":"71.00"},198.11,"N/A","N/A","https://www.selleckchem.com/products/triptonide.html","C20H22O6","free base","N/A","CC(C)C12OC1C3OC34C5(C)CCC6=C(COC6=O)C5CC7OC47C2=O",1.259,6,0,1]
["S9159","momordin-Ic","a3","L6000-03","in 10mM DMSO","SUMO","Ubiquitin","Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo.",764.94,"96990-18-0",{"v":100,"d":"100.00"},130.73,"N/A","N/A","https://www.selleckchem.com/products/momordin-ic.html","C41H64O13","free base","N/A","CC1(C)CCC2(CCC3(C)C(=CCC4C5(C)CCC(OC6OC(C(O)C(OC7OCC(O)C(O)C7O)C6O)C(O)=O)C(C)(C)C5CCC34C)C2C1)C(O)=O",3.591,6,5,6]
["S8904","USP25/28 inhibitor AZ1","b3","L6000-03","in 10mM DMSO","DUB","Ubiquitin","AZ1 is a  potent and noncompetitive dual Inhibitors of the ubiquitin-specific protease (USP) 25/28 with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively.",422.21,"2165322-94-9",{"v":84,"d":"84.00"},198.95,"<1","N/A","http://www.selleck.cn/products/usp25-28-inhibitor-az1.html","C17H16BrF4NO2","Free Base","N/A","OCCNCC1=C(OCC2=CC(=C(F)C=C2)C(F)(F)F)C=CC(=C1)Br",4.291,1,2,8]
["S4922","NSC 632839","c3","L6000-03","in 10mM DMSO","DUB,SUMO","Ubiquitin","NSC 632839 is not only a DUB inhibitor, but also a deSUMOylase inhibitor, it inhibits USP2, USP7, and SENP2 with EC50 of 45 μM, 37 μM, and 9.8 μM, respectively.",339.86,"157654-67-6",{"v":7,"d":"7.00"},{"v":20.6,"d":"20.60"},"<1","N/A","http://www.selleckchem.com/products/nsc-632839.html","C21H21NO.HCl","Free Base","N/A","Cl.CC1=CC=C(C=C1)\\C=C2/CNC\\C(=C/C3=CC=C(C)C=C3)C2=O",4.726,1,1,2]
["S6794","Thalidomide-O-COOH (Cereblon ligand 3)","d3","L6000-03","in 10mM DMSO","E3 Ligase ,E3 ligase Ligand","Ubiquitin","Thalidomide-O-COOH (Cereblon ligand 3, E3 ligase Ligand 3), a Thalidomide-based Cereblon (CRBN) ligand, is used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs (Proteolysis Targeting Chimera).",332.27,"1061605-21-7",{"v":66,"d":"66.00"},198.63,"<1","N/A","http://www.selleckchem.com/products/thalidomide-o-cooh.html","C15H12N2O7","Free Base","E3 ligase Ligand 3","OC(=O)COC1=CC=CC2=C1C(=O)N(C3CCC(=O)NC3=O)C2=O",-0.438,6,1,4]
["S8888","GMB-475","e3","L6000-03","in 10mM DMSO","Bcr-Abl,E3 Ligase ,PROTAC","Angiogenesis","GMB-475 is a proteolysis-targeting chimera (PROTAC) that allosterically targets BCR-ABL1 protein and recruit the E3 ligase Von Hippel-Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein.",861.93,"2490599-18-1",{"v":100,"d":"100.00"},116.02,"<1","N/A","http://www.selleckchem.com/products/gmb-475.html","C43H46F3N7O7S","Free Base","N/A","CC1=C(SC=N1)C2=CC=C(CNC(=O)C3CC(O)CN3C(=O)C(NC(=O)COCCOC4=CC=C(C=C4)C5=CC(=NC=N5)NC6=CC=C(OC(F)(F)F)C=C6)C(C)(C)C)C=C2",6.683,9,4,18]
["S0095","VL285","f3","L6000-03","in 10mM DMSO","E3 Ligase ,E3 ligase Ligand,PROTAC","Ubiquitin","VL285 is a potent VHL ligand that degrades HaloTag7 fusion proteins. Cotreatment with excess VL285, the core VHL ligand from which HaloPROTAC3 is derived, is able to significantly reduce HaloPROTAC3 mediated activity to 50% degradation.",532.65,"1448188-57-5",{"v":100,"d":"100.00"},187.74,"<1","N/A","http://www.selleckchem.com/products/vl285.html","C29H32N4O4S","free base","N/A","CC(C)C(N1CC2=CC=CC=C2C1=O)C(=O)N3CC(O)CC3C(=O)NCC4=CC=C(C=C4)C5=C(C)N=CS5",2.287,4,2,7]
["S0097","(S,R,S)-AHPC (MDK7526)","g3","L6000-03","in 10mM DMSO","Androgen Receptor,E3 Ligase ,E3 ligase Ligand,PROTAC","Ubiquitin","(S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. (S,R,S)-AHPC can be connected to the ligand for protein such as BCR-ABL1 by a linker to form PROTACs such as GMB-475. GMB-475 induces the degradation of BCR-ABL1 with IC50 of 1.11 μM in Ba/F3 cells.",430.56,"1448297-52-6",{"v":86,"d":"86.00"},199.74,{"v":10,"d":"10.00"},23.23,"http://www.selleckchem.com/products/s-r-s-ahpc-mdk7526.html","C22H30N4O3S","free base","VH032-NH2, VHL ligand 1","CC1=C(SC=N1)C2=CC=C(CNC(=O)C3CC(O)CN3C(=O)C(N)C(C)(C)C)C=C2",0.915,3,3,6]
["S0219","ML241 hydrochloride","h3","L6000-03","in 10mM DMSO","ATPase","Transmembrane Transporters","ML241 hydrochloride is a potent and selective inhibitor of p97 with IC50 of 0.11 μM and 3.5 μM for p97 ATPase and UbG76V–GFP, respectively.",408.92,"2070015-13-1",{"v":74,"d":"74.00"},180.96,"<1","N/A","http://www.selleckchem.com/products/ml-241-hcl.html","C23H25ClN4O","free base","N/A","Cl.C1CCC2=C(NCC3=CC=CC=C3)N=C(N=C2C1)N4CCOC5=C4C=CC=C5",5.964,3,1,4]
["S0346","NAcM-OPT","a4","L6000-03","in 10mM DMSO","ADC Cytotoxin,E2 conjugating","Ubiquitin","NAcM-OPT is a specific, reversible and orally bioavailable inhibitor of cullin neddylation 1 (DCN1) that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.",{"v":434.4,"d":"434.40"},"2089293-61-6",{"v":87,"d":"87.00"},200.28,"<1","N/A","http://www.selleckchem.com/products/nacm-opt.html","C23H29Cl2N3O","free base","N/A","CCCCN1CCC(CC1)N(CC2=CC=CC=C2)C(=O)NC3=CC=C(Cl)C(=C3)Cl",5.504,1,1,7]
["S3269","Acetylcorynoline","b4","L6000-03","in 10mM DMSO","Anti-infection,Apoptosis related,Proteasome","Immunology & Inflammation","Acetylcorynoline, a major alkaloid component derived from Corydalis bungeana which is a traditional Chinese medical herb, shows anti-inflammatory properties. Acetylcorynoline may decrease egl-1 expression to suppress apoptosis pathways and increase rpn5 expression to enhance the activity of proteasomes.",409.43,"18797-80-3",{"v":40,"d":"40.00"},{"v":97.7,"d":"97.70"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/acetylcorynoline.html","C23H23NO6","free base","N/A","CN1CC2=C(C=CC3=C2OCO3)C4(C)C(CC5=CC6=C(OCO6)C=C5C14)OC(C)=O",3.111,6,0,2]
["S6845","GRL0617","c4","L6000-03","in 10mM DMSO","DUB,SARS-CoV","Ubiquitin","GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLPro)/deubiquitinase with IC50 of 0.6 μM and Ki of 0.49 μM. GRL0617 inhibits SARS-CoV viral replication in Vero E6 cells with EC50 of 15 microM and has no associated cytotoxicity.",304.39,"1093070-16-6",{"v":65,"d":"65.00"},213.54,"<1","N/A","http://www.selleckchem.com/products/grl0617.html","C20H20N2O","free base","N/A","CC(NC(=O)C1=C(C)C=CC(=C1)N)C2=CC=CC3=CC=CC=C23",3.647,1,2,3]
["S6851","RA-190","d4","L6000-03","in 10mM DMSO","Autophagy,p53,Proteasome","Ubiquitin","RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.",596.76,"1617495-03-0",{"v":100,"d":"100.00"},167.57,"<1","N/A","http://www.selleckchem.com/products/ra-190.html","C28H23Cl5N2O2","free base","N/A","Cl.NC(CC1=CC=CC=C1)C(=O)N2CC(=C/C3=CC(=C(Cl)C=C3)Cl)/C(=O)C(/C2)=C\\C4=CC(=C(Cl)C=C4)Cl",7.285,2,1,5]
["S6877","EOAI3402143","e4","L6000-03","in 10mM DMSO","Apoptosis related,DUB","Ubiquitin","EOAI3402143 is a dose-dependent inhibitor of Usp9x, Usp24 and Usp5 that increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice.",503.42,"1699750-95-2",{"v":100,"d":"100.00"},198.64,"<1","N/A","http://www.selleckchem.com/products/eoai3402143.html","C25H28Cl2N4O3","free base","N/A","CCCC(NC(=O)/C(=C/C1=C(Cl)C=CC(=N1)Cl)C#N)C2=CC=C(OCCN3CCOCC3)C=C2",4.911,4,1,10]
["S6878","GSK2643943A","f4","L6000-03","in 10mM DMSO","DUB","Ubiquitin","GSK2643943A is an inhibitor of deubiquitylating enzyme (DUB) with IC50 of 160 nM for USP20/Ub-Rho.",{"v":277.3,"d":"277.30"},"2449301-27-1",{"v":55,"d":"55.00"},198.34,"<1","N/A","http://www.selleckchem.com/products/gsk2643943a.html","C17H12FN3","free base","N/A","NC1=C(C#N)C2=C([NH]1)C=C(\\C=C\\C3=CC(=CC=C3)F)C=C2",3.571,0,2,2]
["S7394","MDL-28170","g4","L6000-03","in 10mM DMSO","Cysteine Protease","Proteases","MDL-28170 (Calpain Inhibitor III) is a potent and selective calpain inhibitor of calpain that penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration. MDL-28170 is also an inhibitor of γ-secretase.",382.45,"88191-84-8",{"v":76,"d":"76.00"},198.72,"<1","N/A","http://www.selleckchem.com/products/mdl-28170.html","C22H26N2O4","free base","Calpain Inhibitor III","CC(C)C(NC(=O)OCC1=CC=CC=C1)C(=O)NC(CC2=CC=CC=C2)C=O",3.531,4,2,10]
["S8449","VH298","h4","L6000-03","in 10mM DMSO","E3 Ligase ,HIF,PROTAC","Ubiquitin","VH298 is a potent VHL (Von Hippel-Lindau, the E3 ligase) inhibitor that stabilizes HIF-α. VH298 blocks the VHL:HIF-α interaction with Kd of 90 nM in isothermal titration calorimetry (ITC) and 80 nM in a competitive fluorescence polarization assay. VH-298 can be used in PROTAC technology.",523.65,"2097381-85-4",{"v":100,"d":"100.00"},190.97,"<1","N/A","http://www.selleckchem.com/products/vh298.html","C27H33N5O4S","free base","N/A","CC1=C(SC=N1)C2=CC=C(CNC(=O)C3CC(O)CN3C(=O)C(NC(=O)C4(CC4)C#N)C(C)(C)C)C=C2",1.504,4,3,8]
["S8975","Mezigdomide (CC-92480)","a5","L6000-03","in 10mM DMSO","E3 Ligase","Ubiquitin","Mezigdomide (CC-92480) is a novel protein degrader and a cereblon E3 ligase modulator (CELMoD) that has anti-myeloma activity.",567.61,"2259648-80-9",{"v":100,"d":"100.00"},176.18,"<1","N/A","http://www.selleckchem.com/products/cc-92480.html","C32H30FN5O4","free base","N/A","FC1=CC(=CC=C1N2CCN(CC2)CC3=CC=C(COC4=CC=CC5=C4CN(C6CCC(=O)NC6=O)C5=O)C=C3)C#N",3.586,4,1,7]
["S9605","Apcin","b5","L6000-03","in 10mM DMSO","APC,CDK,E3 Ligase","Ubiquitin","Apcin (APC inhibitor) is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C) that binds to Cdc20 and competitively inhibits the ubiquitylation of D-box-containing substrates.",438.65,"300815-04-7",{"v":88,"d":"88.00"},200.62,"<1","N/A","http://www.selleckchem.com/products/apcin.html","C13H14Cl3N7O4","free base","N/A","CC1=NC=C([N]1CCOC(=O)NC(NC2=NC=CC=N2)C(Cl)(Cl)Cl)[N+]([O-])=O",2.035,5,2,9]
["S0515","PLpro inhibitor","c5","L6000-03","in 10mM DMSO","DUB,SARS-CoV","Ubiquitin","PLpro inhibitor (compound 6) is a potent papain-like protease (PLpro)/deubiquitinase (DUBs) inhibitor with IC50 of 2.6 μM and EC50 of 13.1 μM that blocks SARS virus replication.",346.42,"1093070-14-4",{"v":69,"d":"69.00"},199.18,"<1","N/A","https://www.selleckchem.com/products/plpro-inhibitor.html","C22H22N2O2","Free Base","N/A","CC(NC(=O)C1=C(C)C=CC(=C1)NC(C)=O)C2=CC=CC3=CC=CC=C23",3.514,2,2,4]
["S0884","RA-9","d5","L6000-03","in 10mM DMSO","Apoptosis related,DUB","Ubiquitin","RA-9 is a cell-permeable, potent and selective inhibitor of proteasome-associated deubiquitinating enzymes (DUBs) with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines.",365.34,"919091-63-7",{"v":8,"d":"8.00"},{"v":21.9,"d":"21.90"},"<1","N/A","https://www.selleckchem.com/products/ra-9.html","C19H15N3O5","Free Base","N/A","[O-][N+](=O)C1=CC=C(C=C1)\\C=C2/CNC\\C(=C/C3=CC=C(C=C3)[N+]([O-])=O)C2=O",{"v":3.16,"d":"3.160"},1,1,4]
["S8979","THAL-SNS-032","e5","L6000-03","in 10mM DMSO","CDK,E3 Ligase ,PROTAC","Cell Cycle","THAL-SNS-032 is a selective Cyclin-dependent kinase 9 (CDK9) degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).",869.02,"2139287-33-3",{"v":100,"d":"100.00"},115.07,"<1","N/A","https://www.selleckchem.com/products/thal-sns-032.html","C40H52N8O10S2","Free Base","N/A","CC(C)(C)C1=CN=C(CSC2=CN=C(NC(=O)C3CCN(CC3)CC(=O)NCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C6CCC(=O)NC6=O)C5=O)S2)O1",0.997,12,4,22]
["S9444","Tomatine","f5","L6000-03","in 10mM DMSO","Fungal","Microbiology","Tomatine (Lycopersicin) is a natural glycoalkaloid with fungicidal, antimicrobial, and insecticidal properties.",1034.19,"17406-45-0",{"v":100,"d":"100.00"},96.69,{"v":-1,"d":"-1.00"},"N/A","https://www.selleckchem.com/products/tomatine.html","C50H83NO21","Free Base","Lycopersicin","CC1CCC2(NC1)OC3CC4C5CCC6CC(CCC6(C)C5CCC4(C)C3C2C)OC7OC(CO)C(OC8OC(CO)C(O)C(OC9OCC(O)C(O)C9O)C8OC%10OC(CO)C(O)C(O)C%10O)C(O)C7O",{"v":-1.86,"d":"-1.860"},9,13,11]
["S4432","Ixazomib Citrate (MLN9708)","g5","L6000-03","in 10mM DMSO","Proteasome","Proteases","Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.",517.12,"1239908-20-3",{"v":100,"d":"100.00"},193.38,"<1","N/A","http://www.selleckchem.com/products/ixazomib-citrate.html","C20H23BCl2N2O9","Free Base","Ninlaro","CC(C)CC(NC(=O)CNC(=O)C1=C(Cl)C=CC(=C1)Cl)B2OC(=O)C(CC(O)=O)(CC(O)=O)O2",3.497,7,2,11]
["S9724","SZL P1-41","h5","L6000-03","in 10mM DMSO","Apoptosis related,E3 Ligase","Ubiquitin","SZL P1-41 (compound #25) is a specific inhibitor of S-phase kinase-associated protein 2 (Skp2) that indeed binds to Skp2, prevents Skp2-Skp1 interaction and inhibits Skp2 SCF E3 ligase activity, which consequently suppresses survival of cancer cells and cancer stem cells. SZL P1-41 causes higher apoptosis rates in cancer cells.",420.52,"222716-34-9",{"v":5,"d":"5.00"},11.89,"<1","N/A","http://www.selleckchem.com/products/szl-p1-41.html","C24H24N2O3S","Free Base","N/A","CCC1=C(O)C(=C2OC=C(C(=O)C2=C1)C3=NC4=C(S3)C=CC=C4)CN5CCCCC5",5.048,3,1,4]
["E0392","Dubs-IN-1","a6","L6000-03","in 10mM DMSO","DUB","Ubiquitin","Dubs-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.85 μM for USP8.",337.33,"924296-18-4",{"v":17,"d":"17.00"},{"v":50.4,"d":"50.40"},"<1","N/A","https://www.selleckchem.com/products/dubs-in-1.html","C20H11N5O","free base","N/A","N#CC1=C(N=C2/C(=N/OCC3=CC=CC=C3)C4=CC=CC=C4C2=N1)C#N",3.783,4,0,3]
["E1214","KSQ-4279","b6","L6000-03","in 10mM DMSO","DUB","Ubiquitin","KSQ-4279 (USP1-IN-1) is an orally bioavailable selective inhibitor of the  ubiquitin specific protease 1 (USP1)  with anti-proliferative activity. KSQ-4279 also exhibits synergistic activity in combination with PARP inhibitors.",534.54,"2446480-97-1",{"v":100,"d":"100.00"},187.08,"<1","N/A","https://www.selleckchem.com/products/ksq-4279.html","C27H25F3N8O","free base","USP1-IN-1","COC1=C(C2=NC=C3C=N[N](CC4=CC=C(C=C4)C5=NC(=C[N]5C(C)C)C(F)(F)F)C3=N2)C(=NC=N1)C6CC6",5.203,7,0,8]
["E1215","JQAD1","c6","L6000-03","in 10mM DMSO","Histone Acetyltransferase","Epigenetics","JQAD1 is a CRBN-dependent PROTAC that selectively targets EP300 for degradation.",932.95,"2417097-18-6",{"v":100,"d":"100.00"},107.19,"<1","N/A","https://www.selleckchem.com/products/jqad1.html","C48H52F4N6O9","free base","N/A","CC(N(CC1=CC=C(F)C=C1)C(=O)CN2C(=O)OC3(CCC4=CC(=CC=C34)NC(=O)CCCCCCCCCCCNC5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)C2=O)C(F)(F)F",7.276,9,3,21]
["E1216","Heclin","d6","L6000-03","in 10mM DMSO","Others","Others","Heclin is an inhibitor of HECT-type E3 ubiquitin ligase with an IC50 of 6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT domains, respectively.",283.32,"890605-54-6",{"v":57,"d":"57.00"},201.19,"<1","N/A","https://www.selleckchem.com/products/heclin.html","C17H17NO3","free base","N/A","CCC1=CC=C(O1)C=CC(=O)NC2=CC=C(C=C2)C(C)=O",3.029,3,1,5]
["E1300","SJ6986","e6","L6000-03","in 10mM DMSO","E3 Ligase","Ubiquitin","SJ6986 is a CRBN modulator and specifically degrades GSPT1/2, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1.",{"v":497.4,"d":"497.40"},"2765625-93-0",{"v":99,"d":"99.00"},199.03,"<1","N/A","https://www.selleckchem.com/products/sj6986.html","C20H14F3N3O7S","free base","N/A","FC(F)(F)OC1=C(C=CC=C1)[S](=O)(=O)NC2=CC=C3C(=O)N(C4CCC(=O)NC4=O)C(=O)C3=C2",2.704,7,2,6]
["E1330","Usp22i-S02","f6","L6000-03","in 10mM DMSO","DUB","Ubiquitin","Usp22i-S02(USP22-IN-1, compound S02) is a potent inhibitor of ubiquitin specific peptidase 22 (USP22). It showed anticancer activity by suppressing Foxp3 expression in T-regulatory cells.",338.41,"309735-96-4",{"v":68,"d":"68.00"},200.94,"<1","N/A","https://www.selleckchem.com/products/usp22i-s02.html","C22H18N4","free base","USP22-IN-1, compound S02","N#CC1=C2CCCCC2=C(NC3=CC=CC=C3)[N]4C5=CC=CC=C5N=C14",5.817,1,1,2]
["E1381","NX-2127","g6","L6000-03","in 10mM DMSO","BTK","Angiogenesis","NX-2127 is a unique, potent inhibitor of BTK that prevents its functions by catalyzing the ubiquitylation and proteasomal degradation of BTK rather than via direct binding. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells.",719.83,"2416131-46-7",{"v":100,"d":"100.00"},138.92,"<1","N/A","https://www.selleckchem.com/products/nx-2127.html","C39H45N9O5","free base","N/A","NC(=O)C1=NC=C(N=C1NC2=CC=C(C=C2)C3CCN(CC3)CC4CCN(C4)C5=CC=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=C5)N8CCCCC8",3.536,7,3,9]
["E1427","MRT-2359","h6","L6000-03","in 10mM DMSO","E3 Ligase","Ubiquitin","MRT-2359 is a potent degrader of GSPT1. It exhibits anti-tumor activity in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells.",495.38,"2803881-11-8",{"v":100,"d":"100.00"},201.87,"<1","N/A","https://www.selleckchem.com/products/mrt-2359.html","C22H17F4N3O6","free base","N/A","FC1=CC=C(OC(F)(F)F)C=C1NC(=O)OCC2=CC=C3CN(C4CCC(=O)NC4=O)C(=O)C3=C2",3.904,6,2,7]
["S9865","CB-5339","a7","L6000-03","in 10mM DMSO","p97","Ubiquitin","CB-5339 is a potent p97/Valosin Containing Protein (VCP) inhibitor with an IC50 of 9 nM.",412.49,"1863952-15-1",{"v":100,"d":"100.00"},242.43,"<1","N/A","https://www.selleckchem.com/products/cb-5339.html","C24H24N6O","free base","N/A","CC1=CC2=C(C=CC=C2[N]1C3=NC(=C4CCCN=C4N3)NCC5=CC=CC=C5)C(N)=O",3.683,3,3,5]
["E1412","DEG-35","b7","L6000-03","in 10mM DMSO","Casein Kinase","Metabolism","DEG-35 is a cereblon-dependent degrader of IKZF2 and casein kinase 1α (CK1α). It blocks cell growth and delays leukemia progression in murine and human acute myeloid leukemia (AML) mouse models.",443.45,"N/A",{"v":89,"d":"89.00"},{"v":200.7,"d":"200.70"},"<1","N/A","https://www.selleckchem.com/products/deg-35.html","N/A","free base","N/A","COC1=CC2=C(C=C1)C=C(C=C2)C(=O)NC3=CC=C4C(=O)N(CC4=C3)C5CCC(=O)NC5=O",1.908,5,2,4]
["E1575","EN450","c7","L6000-03","in 10mM DMSO","NF-κB","NF-κB","EN450 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. It interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D that induces the ternary complex formation between UBE2D and NFKB1. It exhibits anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism.",288.75,"793719-01-4",{"v":58,"d":"58.00"},200.87,"<1","N/A","https://www.selleckchem.com/products/en450.html","C11H13ClN2O3S","free base","N/A","CN(C)[S](=O)(=O)C1=CC(=C(Cl)C=C1)NC(=O)C=C",1.429,3,1,4]
["E1812","N6F11","d7","L6000-03","in 10mM DMSO","Ferroptosis","Apoptosis","N6F11 is an inducer of ferroptosis. N6F11 is bound to the RING domain of the E3 ubiquitin ligase tripartite motif containing 25 (TRIM25) in cancer cells to trigger TRIM25-mediated K48-linked ubiquitination of glutathione peroxidase 4 (GPX4), resulting in proteasomal degradation.",311.19,"851398-76-0",{"v":20,"d":"20.00"},64.27,"<1","N/A","https://www.selleckchem.com/products/n6f11.html","C13H8Cl2N2OS","free base","N/A","ClCC1=NC(=O)C2=C(N1)C=C(S2)C3=CC=C(Cl)C=C3",3.789,2,1,2]
["E1413","DEG-77","e7","L6000-03","in 10mM DMSO","Casein Kinase","Metabolism","DEG-77 is a cereblon-dependent degrader of IKZF2 and casein kinase 1α (CK1α). It blocks cell growth and delays leukemia progression in murine and human acute myeloid leukemia (AML) mouse models.",447.44,"N/A",{"v":45,"d":"45.00"},100.57,"<1","N/A","https://www.selleckchem.com/products/deg-77.html","N/A","free base","N/A","COC1=CC=CC2=C1OCC(=C2)C(=O)NC3=CC=C4C(=O)N(CC4=C3)C5CCC(=O)NC5=O",1.165,6,2,4]
["E1479","I-138","f7","L6000-03","in 10mM DMSO","DUB","Ubiquitin","I-138 is an orally active, potent reversible inhibitor of USP1-UAF1 with IC50 0f 4.1 nM. I-138 is structurally related to ML323 and induces the monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells and increases PCNA and FANCD2 monoubiquitination in HAP-1 USP1 WT cells.",{"v":492.5,"d":"492.50"},"2098211-50-6",{"v":99,"d":"99.00"},201.02,"<1","N/A","https://www.selleckchem.com/products/i-138.html","C26H23F3N6O","free base","N/A","CC(C)C1=C(C=CC=C1)C2=NC=C3NC(=O)N(CC4=CC=C(C=C4)C5=NC(=C[N]5C)C(F)(F)F)C3=N2",5.445,4,1,6]
["S1360","GSK1059615","a2","L6000-04","in 2mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. Phase 1.",333.36,"958852-01-2",{"v":2,"d":"2.00"},{"v":6,"d":"6.00"},"<1","N/A","http://selleckchem.com/products/GSK1059615.html","C18H11N3O2S","Free Base","N/A","O=C1NC(=O)/C(S1)=C/C2=CC=C3N=CC=C(C4=CC=NC=C4)C3=C2",2.496,4,1,2]
["S2628","Gedatolisib (PKI-587)","b2","L6000-04","in 2mM DMSO","mTOR,PI3K","PI3K/Akt/mTOR","Gedatolisib (PF-05212384, PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM in cell-free assays, respectively. Phase 2.",615.73,"1197160-78-3",{"v":2,"d":"2.00"},3.25,"<1","N/A","http://selleckchem.com/products/pki587.html","C32H41N9O4","Free Base","PF-05212384","CN(C)C1CCN(CC1)C(=O)C2=CC=C(NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6)C=C2",2.525,7,2,7]
["S2827","Torin 1","c2","L6000-04","in 2mM DMSO","Autophagy,mTOR","PI3K/Akt/mTOR","Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM in cell-free assays; exhibits 1000-fold selectivity for mTOR than PI3K.",607.62,"1222998-36-8",{"v":2,"d":"2.00"},3.29,"<1","N/A","http://selleckchem.com/products/torin-1.html","C35H28F3N5O2","Free Base","N/A","CCC(=O)N1CCN(CC1)C2=CC=C(C=C2C(F)(F)F)N3C(=O)C=CC4=C3C5=CC(=CC=C5N=C4)C6=CC7=CC=CC=C7N=C6",5.914,4,0,5]
["S7035","XL388","d2","L6000-04","in 2mM DMSO","mTOR","PI3K/Akt/mTOR","XL388 is a highly potent, selective, ATP-competitive inhibitor of  mTOR with IC50 of 9.9 nM, 1000-fold selectivity over the closely related PI3K kinases.",{"v":455.5,"d":"455.50"},"1251156-08-7",1.25,2.74,"<1","N/A","http://selleckchem.com/products/xl388.html","C23H22FN3O4S","free base","N/A","CC1=C(F)C(=CC=C1C(=O)N2CCOC3=CC=C(C=C3C2)C4=CN=C(N)C=C4)[S](C)(=O)=O",3.007,5,1,3]
["S7085","IWP-2","e2","L6000-04","in 2mM DMSO","Casein Kinase,Wnt/beta-catenin","Stem Cells & Wnt","IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ.",{"v":466.6,"d":"466.60"},"686770-61-6",{"v":4,"d":"4.00"},8.57,"<1","N/A","http://selleckchem.com/products/iwp-2.html","C22H18N4O2S3","Free Base","N/A","CC1=CC2=C(C=C1)N=C(NC(=O)CSC3=NC4=C(SCC4)C(=O)N3C5=CC=CC=C5)S2",4.277,4,1,5]
["S0399","SJB2-043","f2","L6000-04","in 2mM DMSO","DUB","Ubiquitin","SJB2-043 is a potent USP1 inhibitor that inhibits the activity of native USP1/UAF1 with IC50 of 544 nM.",275.26,"63388-44-3",{"v":1.5,"d":"1.50"},5.45,"<1","N/A","http://www.selleckchem.com/products/sjb2-043.html","C17H9NO3","free base","N/A","O=C1C2=C(N=C(O2)C3=CC=CC=C3)C(=O)C4=C1C=CC=C4",{"v":3.35,"d":"3.350"},4,0,1]
["E1678","SPOP-i-6lc","g2","L6000-04","in 2mM DMSO","E3 Ligase","Ubiquitin","SPOP-i-6lc is a selective speckle-type POZ protein (SPOP) E3 ubiquitin ligase inhibitor with IC50 of 2.1 μM and 3.5 μM, in A498 and OS-RC-2 cell lines, respectively. In vitro, It suppresses viability and proliferation of A498 and OS-RC-2 kidney cancer cell lines.",505.64,"2136270-56-7",{"v":5,"d":"5.00"},9.89,"<1","N/A","https://www.selleckchem.com/products/spop-i-6lc.html","C26H31N7O2S","free base","N/A","CN1CCN(CCNC(=O)C2=CC3=C(N=C4N(C=CC=C4C)C3=O)N(CCC5=CC=CS5)C2=N)CC1",1.368,3,1,7]