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{"sheet":"General Information","index":0,"n_rows":94,"n_cols":14,"rows_kept":94,"merged":[[0,3,0,13],[1,1,1,13],[2,0,2,13],[3,1,3,13],[4,1,4,2],[4,3,4,13],[5,1,5,2],[5,3,5,13],[6,1,7,2],[6,3,6,13],[7,3,7,13],[8,1,8,2],[8,3,8,13],[9,1,11,2],[9,3,9,13],[10,3,10,13],[11,3,11,13],[14,1,14,13],[16,1,17,1],[16,2,17,2],[16,13,17,13],[18,1,19,1],[18,2,19,2],[18,13,19,13],[20,1,21,1],[20,2,21,2],[20,13,21,13],[22,1,23,1],[22,2,23,2],[22,13,23,13],[24,1,25,1],[24,2,25,2],[24,13,25,13],[26,1,27,1],[26,2,27,2],[26,13,27,13],[28,1,29,1],[28,2,29,2],[28,13,29,13],[30,1,31,1],[30,2,31,2],[30,13,31,13],[35,1,35,13],[37,1,38,1],[37,2,38,2],[37,13,38,13],[39,1,40,1],[39,2,40,2],[39,13,40,13],[41,1,42,1],[41,2,42,2],[41,13,42,13],[43,1,44,1],[43,2,44,2],[43,13,44,13],[45,1,46,1],[45,2,46,2],[45,12,46,12],[45,13,46,13],[47,1,48,1],[47,2,48,2],[47,12,48,12],[47,13,48,13],[49,1,50,1],[49,2,50,2],[49,12,50,12],[49,13,50,13],[51,1,52,1],[51,2,52,2],[51,12,52,12],[51,13,52,13],[56,1,56,13],[58,1,59,1],[58,2,59,2],[58,4,59,4],[58,5,59,5],[58,6,59,6],[58,7,59,7],[58,8,59,8],[58,9,59,9],[58,10,59,10],[58,11,59,11],[58,12,59,12],[58,13,59,13],[60,1,61,1],[60,2,61,2],[60,4,61,4],[60,5,61,5],[60,6,61,6],[60,7,61,7],[60,8,61,8],[60,9,61,9],[60,10,61,10],[60,11,61,11],[60,12,61,12],[60,13,61,13],[62,1,63,1],[62,2,63,2],[62,4,63,4],[62,5,63,5],[62,6,63,6],[62,7,63,7],[62,8,63,8],[62,9,63,9],[62,10,63,10],[62,11,63,11],[62,12,63,12],[62,13,63,13],[64,1,65,1],[64,2,65,2],[64,4,65,4],[64,5,65,5],[64,6,65,6],[64,7,65,7],[64,8,65,8],[64,9,65,9],[64,10,65,10],[64,11,65,11],[64,12,65,12],[64,13,65,13],[66,1,67,1],[66,2,67,2],[66,4,67,4],[66,5,67,5],[66,6,67,6],[66,7,67,7],[66,8,67,8],[66,9,67,9],[66,10,67,10],[66,11,67,11],[66,12,67,12],[66,13,67,13],[68,1,69,1],[68,2,69,2],[68,3,69,3],[68,4,69,4],[68,5,69,5],[68,6,69,6],[68,7,69,7],[68,8,69,8],[68,9,69,9],[68,10,69,10],[68,11,69,11],[68,12,69,12],[68,13,69,13],[70,1,71,1],[70,2,71,2],[70,3,71,3],[70,4,71,4],[70,5,71,5],[70,6,71,6],[70,7,71,7],[70,8,71,8],[70,9,71,9],[70,10,71,10],[70,11,71,11],[70,12,71,12],[70,13,71,13],[72,1,73,1],[72,2,73,2],[72,3,73,3],[72,4,73,4],[72,5,73,5],[72,6,73,6],[72,7,73,7],[72,8,73,8],[72,9,73,9],[72,10,73,10],[72,11,73,11],[72,12,73,12],[72,13,73,13],[77,1,77,13],[79,1,80,1],[79,2,80,2],[79,4,80,4],[79,5,80,5],[79,6,80,6],[79,7,80,7],[79,8,80,8],[79,9,80,9],[79,10,80,10],[79,11,80,11],[79,12,80,12],[79,13,80,13],[81,1,82,1],[81,2,82,2],[81,4,82,4],[81,5,82,5],[81,6,82,6],[81,7,82,7],[81,8,82,8],[81,9,82,9],[81,10,82,10],[81,11,82,11],[81,12,82,12],[81,13,82,13],[83,1,84,1],[83,2,84,2],[83,4,84,4],[83,5,84,5],[83,6,84,6],[83,7,84,7],[83,8,84,8],[83,9,84,9],[83,10,84,10],[83,11,84,11],[83,12,84,12],[83,13,84,13],[85,1,86,1],[85,2,86,2],[85,4,86,4],[85,5,86,5],[85,6,86,6],[85,7,86,7],[85,8,86,8],[85,9,86,9],[85,10,86,10],[85,11,86,11],[85,12,86,12],[85,13,86,13],[87,1,88,1],[87,2,88,2],[87,4,88,4],[87,5,88,5],[87,6,88,6],[87,7,88,7],[87,8,88,8],[87,9,88,9],[87,10,88,10],[87,11,88,11],[87,12,88,12],[87,13,88,13],[89,1,90,1],[89,2,90,2],[89,4,90,4],[89,5,90,5],[89,6,90,6],[89,7,90,7],[89,8,90,8],[89,9,90,9],[89,10,90,10],[89,11,90,11],[89,12,90,12],[89,13,90,13],[91,1,92,1],[91,2,92,2],[91,3,92,3],[91,4,92,4],[91,5,92,5],[91,6,92,6],[91,7,92,7],[91,8,92,8],[91,9,92,9],[91,10,92,10],[91,11,92,11],[91,12,92,12],[91,13,92,13],[93,1,94,1],[93,2,94,2],[93,3,94,3],[93,4,94,4],[93,5,94,5],[93,6,94,6],[93,7,94,7],[93,8,94,8],[93,9,94,9],[93,10,94,10],[93,11,94,11],[93,12,94,12],[93,13,94,13]]}
[{"$nulls":3},"Methylation Compound Library  (96-well)-L6600"]
[null,"For more information on Selleck library service, please contact us via +1-832-582-8158 or library@selleckchem.com"]
[]
[null,"Product Details:"]
[null,"Description",null,"A unique collection of 167 compounds"]
[null,"Container",null,"96 Deep Well Plate"]
[null,"Stability",null,"12 months | ﹣20°C | in DMSO"]
[{"$nulls":3},"24 months | ﹣80°C | in DMSO"]
[null,"Shipping",null,"Blue ice or Dry ice"]
[null,"Formulation",null,"Solubility ≥10 mM pre-dissolved in 10 mM solution and solubility between 2 mM and 10 mM pre-dissolved in 2 mM solution"]
[{"$nulls":3},"In 10 mM DMSO : Plate layout L6600-01~02;    In 2 mM DMSO : Plate layout L6600-04"]
[{"$nulls":3},"In 10 mM Water: Plate layout L6600-03"]
[]
[]
[null,"Plate layout: L6600-01"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1200","S2400","S3658","S4295","S5266","S6294","S7217","S7296","S7575","S7680","Empty"]
[{"$nulls":3},"Decitabine (NSC 127716)","Rheic Acid","O6-Benzylguanine","Meclofenamate Sodium","Stiripentol","1,3,5-Trimethoxybenzene","OAC1","ML324","LLY-507","SP2509"]
[null,"b","Empty","S1368","S2557","S3722","S4589","S5420","S6479","S7230","S7298","S7581","S7684","Empty"]
[{"$nulls":3},"Acitretin","Terbinafine HCl","Isavuconazole","Amodiaquine dihydrochloride dihydrate","Clindamycin alcoholate","Isohomovanillic acid","UNC0642","AZ5104","GSK J1","Salirasib"]
[null,"c","Empty","S1689","S2821","S3879","S4635","S5445","S7070","S7234","S7353","S7591","S7723","Empty"]
[{"$nulls":3},"Meprednisone","RG108","Kaempferide","Cyproheptadine hydrochloride sesquihydrate","AMI-1 (free acid)","GSK J4 HCl (GSKJ4 HCl)","IOX1","EPZ004777","BRD4770","PRIMA-1"]
[null,"d","Empty","S1725","S2830","S3957","S4771","S5704","S7079","S7237","S7360","S7611","S7748","Empty"]
[{"$nulls":3},"Terbinafine","Clindamycin","Gamma-Oryzanol","β-thujaplicin","Myclobutanil","SGC 0946","OG-L002","Birabresib (OTX015)","EI1","EPZ015666 (GSK3235025)"]
[null,"e","Empty","S1774","S3147","S4021","S4889","S5772","S7110","S7265","S7465","S7616","S7795","Empty"]
[{"$nulls":3},"Thioguanine (NSC 752)","Entacapone","Tolcapone","Perospirone hydrochloride","AS-8351","(+)-JQ1","MM-102","FTI 277 HCl","CPI-169","Iadademstat (ORY-1001) 2HCl"]
[null,"f","Empty","S1782","S3161","S4125","S5104","S5907","S7113","S7276","S7570","S7618","S7796","Empty"]
[{"$nulls":3},"Azacitidine (5-Azacytidine)","Sertaconazole nitrate","Sodium Phenylbutyrate","Tea polyphenol","5-Methyl-2'-deoxycytidine","Zebularine (NSC 309132)","SGI-1027","UNC0379","MI-2 (Menin-MLL Inhibitor)","GSK2879552 2HCl"]
[null,"g","Empty","S1859","S3186","S4251","S5109","S6156","S7165","S7281","S7572","S7619","S7804","Empty"]
[{"$nulls":3},"Diethylstilbestrol","Azatadine dimaleate","Phenothiazine","Ademetionine","5-Methyluridine","UNC1999","JIB-04","A-366","MI-3 (Menin-MLL Inhibitor)","GSK503"]
[null,"h","Empty","S2250","S3639","S4294","S5217","S6216","S7185","S7294","S7574","S7656","S7815","Empty"]
[{"$nulls":3},"(-)-Epigallocatechin Gallate","Tacrine hydrochloride hydrate","Procainamide HCl","Arformoterol Tartrate","1-Methylpyrrolidine","AGI-5198","PFI-2 HCl","GSK-LSD1 2HCl","CPI-360","MI-136"]
[]
[]
[]
[null,"Plate layout: L6600-02"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S7816","S8068","S8340","S8608","S1059","S8883","S8996","E1059","S2943","E1007","Empty"]
[{"$nulls":3},"MI-463","Chaetocin","SGC2085","Adenosine Dialdehyde (ADOX)","KDM4D-IN-1","LLY-283","Revumenib","UNC6934","BRD9539","BRD0639"]
[null,"b","Empty","S7820","S8071","S8353","S8664","S2184","S0201","S9870","S7062","S6984","E1088","Empty"]
[{"$nulls":3},"EPZ020411 2HCl","UNC0638","Lirametostat (CPI-1205)","Pemrametostat (GSK3326595)","WDR5-0103","Z-JIB-04 (NSC 693627)","STM2457","Pinometostat (EPZ5676)","Dianhydrogalactitol (VAL-083)","TP-064"]
[null,"c","Empty","S7832","S8111","S8359","S9031","S8812","S8837","S9882","S7817","S7013","E1167","Empty"]
[{"$nulls":3},"SGC707","GSK591","UNC3866","Gambogenic acid","CM272","FB23-2","PFI-90","MI-503","Guadecitabine (SGI-110)","X1 compound"]
[null,"d","Empty","S7833","S8112","S8438","S9227","S0184","S8918","E0027","S8344","S7042","E1179","Empty"]
[{"$nulls":3},"OICR-9429","MS023","T-3775440 HCl","Sinensetin","XY1","MS1943","5-Hydroxymethylcytosine","AZD-5153 6-hydroxy-2-naphthoic acid","AZ505","EZM0414"]
[null,"e","Empty","S7884","S8147","S8479","S9287","S2477","S7868","S6389","S8983","S8858","Empty","Empty"]
[{"$nulls":3},"AMI-1","MS049","LLY-284","Genkwanin","2'-Deoxy-5-Fluorocytidine","S-Adenosyl-L-homocysteine (SAH)","CPI-455","MAK683","GSK3368715 (EPZ019997) 3HCl"]
[null,"f","Empty","S7983","S8205","S8494","S9328","S6722","S0855","S9876","S9659","S8926","Empty","Empty"]
[{"$nulls":3},"A-196","Enasidenib (AG-221)","PF-06726304","5,6,7-Trimethoxyflavone","Seclidemstat (SP-2577)","TC-E 5003","Dac51","UNC6852","Valemetostat (DS-3201)"]
[null,"g","Empty","S8006","S8209","S8496","S9472","S6779","S2971","E0133","S0269","S8934","Empty","Empty"]
[{"$nulls":3},"BIX 01294","HLCL-61 HCL","EED226","Oxtriphylline","JBSNF-000088","SIBA","NNMTi","GSK467","VTP50469"]
[null,"h","Empty","S8056","S8287","S8607","S6737","S6833","S6291","S3543","S0356","E0132","Empty","Empty"]
[{"$nulls":3},"Lomeguatrib","CPI-455 HCl","JQ-EZ-05 (JQEZ5)","C7280948","BCI-121","FB23","DC-05","Pulrodemstat (CC-90011) besylate","NCGC00244536"]
[]
[]
[]
[null,"Plate layout: L6600-03"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4811","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"VitaMin U"]
[null,"b","Empty","S5545","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"DL-Serine"]
[null,"c","Empty","S7873","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Disodium (R)-2-Hydroxyglutarate"]
[null,"d","Empty","S1325","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"L-2-Hydroxyglutaric acid disodium"]
[null,"e","Empty","E0351","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"NSC232003"]
[null,"f","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"g","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[]
[]
[]
[null,"Plate layout: L6600-04"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S4605","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Folic acid"]
[null,"b","Empty","S7004","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"EPZ005687"]
[null,"c","Empty","S7061","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"GSK126"]
[null,"d","Empty","S7128","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Tazemetostat (EPZ-6438)"]
[null,"e","Empty","S7164","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"GSK343"]
[null,"f","Empty","S9872","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"AG-270"]
[null,"g","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]

{"sheet":"L6600-Methylation-167 cpds","index":1,"n_rows":168,"n_cols":23,"rows_kept":168}
["Cat","Name","Plate Location","Rack Number","Formulation","Target","Pathway","Information","M.w.","CAS Number","DMSO (mg/mL)Max Solubility","DMSO (mM)Max Solubility","Water (mg/mL)Max Solubility","Water (mM)Max Solubility","URL","Formula","Form","Synonyms","SMILES","ALogP","HBA_Count","HBD_Count","RotatableBond"]
["S1200","Decitabine (NSC 127716)","a2","L6600-01","in 10mM DMSO","Apoptosis related,DNA Methyltransferase,Nucleoside Analog/Antimetabolite","Epigenetics","Decitabine (Deoxycytidine, Dacogen, 5-aza-2'-deoxycytidine, 5-AZA-dC, 5-aza-CdR,NSC 127716) is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.",228.21,"2353-33-5",{"v":45,"d":"45.00"},197.19,{"v":10,"d":"10.00"},43.82,"http://selleckchem.com/products/Decitabine.html","C8H12N4O4","free base","Deoxycytidine, Dacogen, 5-aza-2'-deoxycytidine, 5-AZA-dC, 5-aza-CdR,NSC 127716","NC1=NC(=O)N(C=N1)C2CC(O)C(CO)O2",-1.093,4,3,2]
["S1368","Acitretin","b2","L6600-01","in 10mM DMSO","Retinoid Receptor","Metabolism","Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.",326.43,"55079-83-9",{"v":20,"d":"20.00"},61.27,"<1","N/A","http://selleckchem.com/products/Acitretin.html","C21H26O3","free base","Etretin, RO 10-1670","COC1=CC(=C(\\C=C\\C(C)=C\\C=C\\C(C)=C\\C(O)=O)C(=C1C)C)C",5.665,2,0,6]
["S1689","Meprednisone","c2","L6600-01","in 10mM DMSO","Glucocorticoid Receptor","Endocrinology & Hormones","Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.",372.46,"1247-42-3",{"v":75,"d":"75.00"},201.37,"<1","N/A","http://selleckchem.com/products/Betapar(Meprednisone).html","C22H28O5","free base","NSC 527579, SCH 4358","CC1CC2C3CCC4=CC(=O)C=CC4(C)C3C(=O)CC2(C)C1(O)C(=O)CO",1.536,3,1,2]
["S1725","Terbinafine","d2","L6600-01","in 10mM DMSO","Fungal","Microbiology","Terbinafine (SF 86-327,TDT 067) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.",291.43,"91161-71-6",{"v":58,"d":"58.00"},199.02,"<1","N/A","http://selleckchem.com/products/Terbinafine(Lamisil).html","C21H25N","Free Base","SF 86-327,TDT 067","CN(C\\C=C\\C#CC(C)(C)C)CC1=CC=CC2=CC=CC=C12",5.335,0,0,6]
["S1774","Thioguanine (NSC 752)","e2","L6600-01","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Thioguanine (NSC 752, 6-Thioguanine, 2-Amino-6-purinethiol), a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.",167.19,"154-42-7",{"v":9,"d":"9.00"},53.83,"<1","N/A","http://selleckchem.com/products/Thioguanine.html","C5H5N5S","free base","NSC 752,6-Thioguanine, 2-Amino-6-purinethiol","NC1=NC(=S)C2=C(N1)N=C[NH]2",0.236,2,3,0]
["S1782","Azacitidine (5-Azacytidine)","f2","L6600-01","in 10mM DMSO","Autophagy,DNA Methyltransferase,Nucleoside Analog/Antimetabolite","DNA Damage/DNA Repair","Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy.",{"v":244.2,"d":"244.20"},"320-67-2",{"v":48,"d":"48.00"},196.56,"<1","N/A","http://selleckchem.com/products/Azacitidine(Vidaza).html","C8H12N4O5","free base","5-AzaC,Ladakamycin, AZA,5-Aza, CC-486,NSC 102816,5-Azacytidine","NC1=NC(=O)N(C=N1)C2OC(CO)C(O)C2O",-2.505,4,4,2]
["S1859","Diethylstilbestrol","g2","L6600-01","in 10mM DMSO","Estrogen/progestogen Receptor","Endocrinology & Hormones","Diethylstilbestrol (Stilbestrol) is a synthetic nonsteroidal estrogen, used to prevent miscarriage and other pregnancy complications.",268.35,"56-53-1",{"v":54,"d":"54.00"},201.23,"<1","N/A","http://selleckchem.com/products/Diethylstilbestrol(Stilbestrol).html","C18H20O2","free base","Stilbestrol","CCC(/C1=CC=C(O)C=C1)=C(CC)\\C2=CC=C(O)C=C2",5.137,0,2,4]
["S2250","(-)-Epigallocatechin Gallate","h2","L6600-01","in 10mM DMSO","DNA Methyltransferase,EGFR,Fatty Acid Synthase,HER2,Telomerase","DNA Damage/DNA Repair","(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.",458.37,"989-51-5",{"v":72,"d":"72.00"},157.08,{"v":23,"d":"23.00"},50.18,"http://selleckchem.com/products/(-)-Epigallocatechin-gallate.html","C22H18O11","free base","EGCG","OC1=CC2=C(CC(OC(=O)C3=CC(=C(O)C(=C3)O)O)C(O2)C4=CC(=C(O)C(=C4)O)O)C(=C1)O",3.097,3,8,4]
["S2400","Rheic Acid","a3","L6600-01","in 10mM DMSO","FTO,Immunology & Inflammation related","Immunology & Inflammation","Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N6-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.",284.22,"478-43-3",{"v":3,"d":"3.00"},10.56,"<1","N/A","http://www.selleck.cn/products/Rhein-Monorhein.html","C15H8O6","Free Base","Rhein, Monorhein, NSC 38629, Rheinic Acid","OC(=O)C1=CC(=C2C(=O)C3=C(C=CC=C3O)C(=O)C2=C1)O",1.954,3,2,1]
["S2557","Terbinafine HCl","b3","L6600-01","in 10mM DMSO","Fungal","Microbiology","Terbinafine HCl (KWD 201,KWD 2019,TDT 067 hydrochloride) inhibits ergosterol synthesis by inhibiting squalene epoxidase, used as an antifungal drug.",327.89,"78628-80-5",{"v":66,"d":"66.00"},201.29,"<1","N/A","http://selleckchem.com/products/Terbinafine-hydrochloride-Lamisil.html","C21H25N.HCl","Hydrochloride","KWD 201,KWD 2019,TDT 067 hydrochloride","Cl.CN(C\\C=C\\C#CC(C)(C)C)CC1=CC=CC2=C1C=CC=C2",5.717,0,0,6]
["S2821","RG108","c3","L6600-01","in 10mM DMSO","DNA Methyltransferase","Epigenetics","RG108 (N-Phthalyl-L-tryptophan) is an inhibitor of DNA methyltransferase with IC50 of 115 nM in a cell-free assay, does not cause trapping of covalent enzymes.",334.33,"48208-26-0",{"v":67,"d":"67.00"},{"v":200.4,"d":"200.40"},"<1","N/A","http://selleckchem.com/products/rg108.html","C19H14N2O4","free base","N-Phthalyl-L-tryptophan","OC(=O)C(CC1=C[NH]C2=C1C=CC=C2)N3C(=O)C4=CC=CC=C4C3=O",2.677,3,1,4]
["S2830","Clindamycin","d3","L6600-01","in 10mM DMSO","Bacterial","Microbiology","Clindamycin inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.",424.98,"18323-44-9",{"v":85,"d":"85.00"},200.01,"<1","N/A","http://selleckchem.com/products/clindamycin.html","C18H33ClN2O5S","Free Base","N/A","CCCC1CC(N(C)C1)C(=O)NC(C(C)Cl)C2OC(SC)C(O)C(O)C2O",1.277,2,4,7]
["S3147","Entacapone","e3","L6600-01","in 10mM DMSO","COMT,Histone Methyltransferase","Epigenetics","Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.",305.29,"130929-57-6",{"v":61,"d":"61.00"},199.81,"<1","N/A","http://selleckchem.com/products/entacapone.html","C14H15N3O5","free base","OR-611","CCN(CC)C(=O)\\C(=C\\C1=CC(=C(O)C(=C1)O)[N+]([O-])=O)C#N",1.658,1,2,5]
["S3161","Sertaconazole nitrate","f3","L6600-01","in 10mM DMSO","Fungal","Microbiology","Sertaconazole nitrate (FI-7045,FI7056) is a topical broad-spectrum antifungal that is developed to provide an additional agent for the treatment of superficial cutaneous and mucosal infections.",500.78,"99592-39-9",{"v":100,"d":"100.00"},199.69,"<1","N/A","http://selleckchem.com/products/sertaconazole-nitrate.html","C20H15Cl3N2OS.HNO3","Nitrate","FI-7045,FI7056","O[N+]([O-])=O.ClC1=CC=C(C(C[N]2C=CN=C2)OCC3=CSC4=C(Cl)C=CC=C34)C(=C1)Cl",4.584,2,0,6]
["S3186","Azatadine dimaleate","g3","L6600-01","in 10mM DMSO","Histamine Receptor","Neuronal Signaling","Azatadine (SCH10649,Azatadine Maleate) is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.",522.55,"3978-86-7",{"v":105,"d":"105.00"},200.94,{"v":105,"d":"105.00"},200.94,"http://selleckchem.com/products/azatadine-dimaleate.html","C20H22N2.2C4H4O4","Dimaleate","SCH10649,Azatadine Maleate","CN1CCC(CC1)=C2C3=CC=CC=C3CCC4=CC=CN=C24.OC(=O)\\C=C/C(O)=O.OC(=O)\\C=C/C(O)=O",1.128,5,0,4]
["S3639","Tacrine hydrochloride hydrate","h3","L6600-01","in 10mM DMSO","AChR,HNMT","Neuronal Signaling","Tacrine (Tetrahydroaminacrine, Tetrahydroaminoacridine) is a centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. It also acts as a histamine N-methyltransferase inhibitor.","198.26(free bases)","206658-92-6",{"v":50,"d":"50.00"},252.19,{"v":50,"d":"50.00"},252.19,"http://selleckchem.com/products/tacrine-hydrochloride-hydrate.html","C13H14N2.xHCl.xH2O","hydrochloride hydrate","Tacrine, Tetrahydroaminacrine, Tetrahydroaminoacridine","NC1=C2C=CC=CC2=NC3=C1CCCC3",4.258,1,1,0]
["S3658","O6-Benzylguanine","a4","L6600-01","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.",241.25,"19916-73-5",{"v":48,"d":"48.00"},198.96,"<1","N/A","http://selleckchem.com/products/o6-benzylguanine.html","C12H11N5O","free base","O6-BG","NC1=NC2=C(N=C[NH]2)C(=N1)OCC3=CC=CC=C3",1.646,4,2,3]
["S3722","Isavuconazole","b4","L6600-01","in 10mM DMSO","Fungal","Microbiology","Isavuconazole (BAL-4815, RO-0094815) is a new extended-spectrum triazole with activity against yeasts, molds, and dimorphic fungi that inhibits cytochrome P450 (CYP)-dependent 14α-lanosterol demethylation, which is essential for fungal cell membrane ergosterol synthesis.",437.47,"241479-67-4",{"v":87,"d":"87.00"},198.87,"<1","N/A","http://selleckchem.com/products/isavuconazole.html","C22H17F2N5OS","free base","BAL-4815, RO-0094815","CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(O)(C[N]3C=NC=N3)C4=CC(=CC=C4F)F",3.904,3,0,6]
["S3879","Kaempferide","c4","L6600-01","in 10mM DMSO","EGFR","Apoptosis","Kaempferide (4'-Methylkaempferol, 4'-O-Methylkaempferol, Kaempferol 4'-methyl ether), a natural compound derived from the roots of kaempferia galanga, has a variety of effects including anti-carcinogenic, anti-inflammatory, anti-oxidant, anti-bacterial and anti-viral properties.",300.26,"491-54-3",{"v":60,"d":"60.00"},199.83,"<1","N/A","http://selleckchem.com/products/kaempferide.html","C16H12O6","free base","4'-Methylkaempferol, 4'-O-Methylkaempferol, Kaempferol 4'-methyl ether","COC1=CC=C(C=C1)C2=C(O)C(=O)C3=C(O2)C=C(O)C=C3O",2.098,3,3,2]
["S3957","Gamma-Oryzanol","d4","L6600-01","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass.  γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).",602.89,"11042-64-1",{"v":100,"d":"100.00"},165.87,"N/A","N/A","http://selleckchem.com/products/gamma-oryzanol.html","C40H58O4","free base","N/A","COC1=CC(=CC=C1O)/C=C/C(=O)OC2CCC34CC35CCC6(C)C(CCC6(C)C5CCC4C2(C)C)C(C)CCC=C(C)C",9.806,3,1,9]
["S4021","Tolcapone","e4","L6600-01","in 10mM DMSO","COMT,Histone Methyltransferase,Transferase","Metabolism","Tolcapone (Ro 40-7592) is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM.",273.24,"134308-13-7",{"v":55,"d":"55.00"},201.29,"<1","N/A","http://selleckchem.com/products/tolcapone.html","C14H11NO5","free base","Ro 40-7592","CC1=CC=C(C=C1)C(=O)C2=CC(=C(O)C(=C2)[N+]([O-])=O)O",{"v":3.13,"d":"3.130"},1,2,3]
["S4125","Sodium Phenylbutyrate","f4","L6600-01","in 10mM DMSO","HDAC","DNA Damage/DNA Repair","Sodium phenylbutyrate (4-PBA, 4-Phenylbutyric acid, NaPB) is a salt of 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.Sodium phenylbutyrate is a histone deacetylase inhibitor, used to treat urea cycle disorders.",187.19,"1716-12-7",{"v":8,"d":"8.00"},42.97,{"v":30,"d":"30.00"},161.13,"http://selleckchem.com/products/sodium-phenylbutyrate.html","C10H11O2.Na","Sodium Salt","4-PBA, 4-Phenylbutyric acid, NaPB","[Na]OC(=O)CCCC1=CC=CC=C1",2.497,2,0,5]
["S4251","Phenothiazine","g4","L6600-01","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Phenothiazine (ENT 38) is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain.",199.27,"92-84-2",{"v":40,"d":"40.00"},200.73,"<1","N/A","http://selleckchem.com/products/phenothiazine.html","C12H9NS","free base","ENT 38","N1C2=C(SC3=CC=CC=C13)C=CC=C2",3.668,0,1,0]
["S4294","Procainamide HCl","h4","L6600-01","in 10mM DMSO","DNA Methyltransferase,Sodium Channel","Transmembrane Transporters","Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor, used in the treatment of cardiac arrhythmias.",271.79,"614-39-1",{"v":54,"d":"54.00"},198.68,{"v":54,"d":"54.00"},198.68,"http://selleckchem.com/products/procainamide-hcl.html","C13H22ClN3O","Hydrochloride","N/A","Cl.CCN(CC)CCNC(=O)C1=CC=C(N)C=C1",1.509,1,2,6]
["S4295","Meclofenamate Sodium","a5","L6600-01","in 10mM DMSO","COX,FTO","Neuronal Signaling","Meclofenamate Sodium(CI 583) is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.",318.13,"6385-02-0",{"v":63,"d":"63.00"},198.03,{"v":63,"d":"63.00"},198.03,"http://selleckchem.com/products/meclofenamate-sodium.html","C14H11Cl2NO2.Na","Sodium Salt","CI 583","CC1=C(Cl)C(=C(Cl)C=C1)NC2=CC=CC=C2C(=O)O[Na]",4.915,2,1,4]
["S4589","Amodiaquine dihydrochloride dihydrate","b5","L6600-01","in 10mM DMSO","Histone Methyltransferase,HNMT,Transferase","Epigenetics","Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.",464.81,"6398-98-7",{"v":92,"d":"92.00"},197.93,{"v":29,"d":"29.00"},62.39,"http://selleckchem.com/products/amodiaquine-dihydrochloride-dihydrate.html","C20H22ClN3O.2HCl.2H2O","dihydrochloride dihydrate","N/A","O.O.Cl.Cl.CCN(CC)CC1=CC(=CC=C1O)NC2=C3C=CC(=CC3=NC=C2)Cl",5.109,1,2,6]
["S4635","Cyproheptadine hydrochloride sesquihydrate","c5","L6600-01","in 10mM DMSO","5-HT Receptor,SETD","Neuronal Signaling","Cyproheptadine hydrochloride (Periactin, Peritol) is non-selective 5HT2 antagonist with IC50 of 0.6 nM. Also a SETD7/9 inhibitor.",350.88,"41354-29-4",{"v":70,"d":"70.00"},{"v":199.5,"d":"199.50"},"<1","N/A","https://www.selleckchem.com/products/cyproheptadine-hydrochloride-sesquihydrate.html","C21H21N.HCl.3/2H2O","hydrochloride sesquihydrate","Periactin hydrochloride, Peritol","O.O.O.Cl.Cl.CN1CCC(CC1)=C2C3=CC=CC=C3C=CC4=CC=CC=C24.CN5CCC(CC5)=C6C7=CC=CC=C7C=CC8=CC=CC=C68",5.478,0,0,0]
["S4771","β-thujaplicin","d5","L6600-01","in 10mM DMSO","DNA Methyltransferase","Epigenetics","β-Thujaplicin (β-TH, Hinokitiol, 4-Isopropyltropolone) is a toxic tropolone derivative present in the heartwood of western red cedar (Thuja plicata) and is used as a preservative and antimicrobial additive in a number of commercial goods.  Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.",{"v":164.2,"d":"164.20"},"499-44-5",{"v":32,"d":"32.00"},194.88,"N/A","N/A","http://selleckchem.com/products/beta-thujaplicin.html","C10H12O2","free base","Hinokitiol, 4-Isopropyltropolone","CC(C)C1=CC=CC(=O)C(=C1)O",1.896,1,1,1]
["S4889","Perospirone hydrochloride","e5","L6600-01","in 10mM DMSO","5-HT Receptor,Dopamine Receptor","Neuronal Signaling","Perospirone (SM-9018) is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.",463.04,"129273-38-7",{"v":92,"d":"92.00"},198.69,"N/A","N/A","http://selleckchem.com/products/perospirone-hydrochloride.html","C23H30N4O2S.HCl","hydrochloride","SM-9018 hydrochloride","Cl.O=C1C2CCCCC2C(=O)N1CCCCN3CCN(CC3)C4=NSC5=C4C=CC=C5",4.423,3,0,6]
["S5104","Tea polyphenol","f5","L6600-01","in 10mM DMSO","Others","Others","Tea polyphenols are chemical compounds such as flavanoids and tannins found naturally in tea. Several biological properties have been associated to tea polyphenols (TP), including antioxidant, anti-carcinogenic and antimicrobial activities.","N/A","84650-60-2",{"v":100,"d":"100.00"},{"v":10,"d":"10.00"},{"v":100,"d":"100.00"},"N/A","http://selleckchem.com/products/tea-polyphenol.html","N/A","N/A","N/A","N/A",{"v":0,"d":"0.000"},0,0,0]
["S5109","Ademetionine","g5","L6600-01","in 10mM DMSO","Others","Others","Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.",398.44,"29908-03-0",{"v":79,"d":"79.00"},198.27,"N/A","N/A","http://selleckchem.com/products/ademetionine.html","C15H22N6O5S","free base","AdoMet, S-Adenosylmethionine, SAMe","C[S+](CCC(N)C([O-])=O)CC1OC(C(O)C1O)[N]2C=NC3=C2N=CN=C3N",{"v":0,"d":"0.000"},0,0,0]
["S5217","Arformoterol Tartrate","h5","L6600-01","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.",494.49,"200815-49-2",{"v":99,"d":"99.00"},200.21,{"v":-1,"d":"-1.00"},-2.02,"https://www.selleckchem.com/products/arformoterol-tartrate.html","C23H30N2O10","Tartrate","(R, R)-Formoterol","COC1=CC=C(CC(C)NCC(O)C2=CC(=C(O)C=C2)NC=O)C=C1.OC(C(O)C(O)=O)C(O)=O",-2.446,4,6,11]
["S5266","Stiripentol","a6","L6600-01","in 10mM DMSO","P450 (e.g. CYP17)","Metabolism","Stiripentol (BCX2600) is a third-generation anti-epileptic drug that enhances GABAergic neurotransmission. It is an inhibitor of cytochrome P450.",234.29,"49763-96-4",{"v":46,"d":"46.00"},196.34,{"v":13,"d":"13.00"},55.49,"http://selleckchem.com/products/stiripentol.html","C14H18O3","Dioxolane","BCX2600","CC(C)(C)C(O)/C=C/C1=CC=C2OCOC2=C1",2.955,2,1,3]
["S5420","Clindamycin alcoholate","b6","L6600-01","in 10mM DMSO","Antibiotics,Bacterial","Microbiology","Clindamycin alcoholate is a crystallizable compound of Clindamycin with alcohol. Clindamycin is a semisynthetic lincosamide antibiotic that inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits.",479.46,"58207-19-5",{"v":95,"d":"95.00"},198.14,"N/A","N/A","http://selleckchem.com/products/clindamycin-alcoholate.html","C18H33ClN2O5S.HCl.H2O","hydrochloride, monohydrate","N/A","O.Cl.CCCC1CC(N(C)C1)C(=O)NC(C(C)Cl)C2OC(SC)C(O)C(O)C2O",1.451,2,4,7]
["S5445","AMI-1 (free acid)","c6","L6600-01","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.",504.49,"134-47-4",{"v":20,"d":"20.00"},39.64,"N/A","N/A","http://selleckchem.com/products/ami-1-free-acid.html","C21H16N2O9S2","free base","N/A","OC1=C2C=CC(=CC2=CC(=C1)[S](O)(=O)=O)NC(=O)NC3=CC4=CC(=CC(=C4C=C3)O)[S](O)(=O)=O",2.521,1,4,4]
["S5704","Myclobutanil","d6","L6600-01","in 10mM DMSO","Fungal","Microbiology","Myclobutanil is a widely used triazole fungicide and also a steroid demethylation inhibitor.",288.78,"88671-89-0",{"v":58,"d":"58.00"},200.85,{"v":-1,"d":"-1.00"},-3.46,"https://www.selleckchem.com/products/myclobutanil.html","C15H17ClN4","free base","N/A","CCCCC(C[N]1C=NC=N1)(C#N)C2=CC=C(Cl)C=C2",3.719,2,0,6]
["S5772","AS-8351","e6","L6600-01","in 10mM DMSO","Histone Demethylase","Epigenetics","AS-8351 is a histone demethylase inhibitor that could induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.",{"v":291.3,"d":"291.30"},"796-42-9",{"v":58,"d":"58.00"},199.11,"<1","N/A","http://www.selleckchem.com/products/as-8351.html","C17H13N3O2","Free Base","N/A","OC1=CC=C2C=CC=CC2=C1/C=N/NC(=O)C3=CC=NC=C3",2.199,3,2,3]
["S5907","5-Methyl-2'-deoxycytidine","f6","L6600-01","in 10mM DMSO","Others","Others","5-Methyl-2'-deoxycytidine (5-Me-dC, 5-Methyldeoxycytidine, 5MedCyd) is a minor component found in most eukaryotic DNA.",241.24,"838-07-3",{"v":48,"d":"48.00"},198.97,{"v":48,"d":"48.00"},198.97,"http://www.selleckchem.com/products/5-methyl-2-deoxycytidine.html","C10H15N3O4","Free Base","5-Methyldeoxycytidine, 5MedCyd","CC1=CN(C2CC(O)C(CO)O2)C(=O)N=C1N",-1.184,3,3,2]
["S6156","5-Methyluridine","g6","L6600-01","in 10mM DMSO","Others","Others","5-Methyluridine (Ribothymidine, Ribosylthymine, Thymine riboside) is a pyrimidine nucleoside that acts as an human endogenous metabolite.",258.23,"1463-10-1",25.03,96.91,"N/A","N/A","http://www.selleck.cn/products/5-methyluridine.html","C10H14N2O6","free base","Ribothymidine, Ribosylthymine, Thymine riboside","CC1=CN(C2OC(CO)C(O)C2O)C(=O)NC1=O",-2.005,3,4,2]
["S6216","1-Methylpyrrolidine","h6","L6600-01","in 10mM DMSO","Others","Others","1-Methylpyrrolidine is extensively used in the synthesis of pyrrolidine based ionic liquids.",85.15,"120-94-5","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleck.cn/products/1-methylpyrrolidine.html","C5H11N","free base","N/A","CN1CCCC1",0.781,0,0,0]
["S6294","1,3,5-Trimethoxybenzene","a7","L6600-01","in 10mM DMSO","Others","Others","1,3,5-Trimethoxybenzene (Phloroglucinol trimethyl ether, Sym-trimethoxybenzene, Trimethylphloroglucinol) is a potential biomarker of flavonoid intake in human. It is a human xenobiotic metabolite.",168.19,"621-23-8",33.64,{"v":200,"d":"200.00"},"N/A","N/A","http://www.selleck.cn/products/1-3-5-trimethoxybenzene.html","C9H12O3","free base","Phloroglucinol trimethyl ether, Sym-trimethoxybenzene, Trimethylphloroglucinol","COC1=CC(=CC(=C1)OC)OC",{"v":1.78,"d":"1.780"},3,0,3]
["S6479","Isohomovanillic acid","b7","L6600-01","in 10mM DMSO","Others","Others","Isohomovanillic acid is a deaminated metabolite of catecholamines formed by the enzyme catechol-O-methyltransferase which catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine.",182.17,"1131-94-8",{"v":36,"d":"36.00"},197.62,{"v":9,"d":"9.00"},{"v":49.4,"d":"49.40"},"http://www.selleck.cn/products/isohomovanillic-acid.html","C9H10O4","Free Base","N/A","COC1=CC=C(CC(O)=O)C=C1O",1.236,2,1,3]
["S7070","GSK J4 HCl (GSKJ4 HCl)","c7","L6600-01","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family.",453.96,"1797983-09-5",{"v":90,"d":"90.00"},198.26,{"v":90,"d":"90.00"},198.26,"http://selleckchem.com/products/gsk-j4-hcl.html","C24H27N5O2.HCl","Hydrochloride","N/A","Cl.CCOC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=C(CC3)C=CC=C4",4.663,5,1,8]
["S7079","SGC 0946","d7","L6600-01","in 10mM DMSO","DOT1,Histone Methyltransferase","Epigenetics","SGC 0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM in a cell-free assay, is inactive against a panel of 12 PMTs and DNMT1.",618.57,"1561178-17-3",{"v":100,"d":"100.00"},161.66,"<1","N/A","http://selleckchem.com/products/sgc-0946.html","C28H40BrN7O4","free base","N/A","CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2OC(C(O)C2O)[N]3C=C(Br)C4=C3N=CN=C4N",3.278,4,5,10]
["S7110","(+)-JQ1","e7","L6600-01","in 10mM DMSO","Autophagy,Epigenetic Reader Domain,NSD,Target Protein Ligand","Epigenetics","(+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2) in cell-free assays, binding to all bromodomains of the BET family, but not to bromodomains outside the BET family. (+)-JQ1 suppresses cell proliferation via inducing autophagy. (+)-JQ1 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",456.99,"1268524-70-4",{"v":91,"d":"91.00"},199.13,"<1","N/A","http://selleckchem.com/products/jq1.html","C23H25ClN4O2S","free base","N/A","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)OC(C)(C)C)N=C2C4=CC=C(Cl)C=C4)C",4.953,5,0,5]
["S7113","Zebularine (NSC 309132)","f7","L6600-01","in 10mM DMSO","DNA Methyltransferase","Epigenetics","Zebularine (NSC 309132, 4-Deoxyuridine) is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM in a cell-free assay.",{"v":228.2,"d":"228.20"},"3690-10-6",{"v":46,"d":"46.00"},201.58,{"v":46,"d":"46.00"},201.58,"http://selleckchem.com/products/zebularine.html","C9H12N2O5","free base","4-Deoxyuridine","OCC1OC(C(O)C1O)N2C=CC=NC2=O",-1.747,3,3,2]
["S7165","UNC1999","g7","L6600-01","in 10mM DMSO","Apoptosis related,Autophagy,EZH1/2,Histone Methyltransferase","Epigenetics","UNC1999 is a potent, orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays, respectively, showing >1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets. UNC1999 is a potent autophagy inducer. UNC1999 specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation, differentiation, and apoptosis.",569.74,"1431612-23-5",{"v":50,"d":"50.00"},87.76,"<1","N/A","http://selleckchem.com/products/unc1999.html","C33H43N7O2","free base","N/A","CCCC1=C(CNC(=O)C2=CC(=CC3=C2C=N[N]3C(C)C)C4=CC=C(N=C4)N5CCN(CC5)C(C)C)C(=O)NC(=C1)C",4.629,4,2,9]
["S7185","AGI-5198","h7","L6600-01","in 10mM DMSO","Dehydrogenase","Metabolism","AGI-5198 (IDH-C35) is the first highly potent and selective inhibitor of IDH1 R132H/R132C mutants with IC50 of 0.07 μM/0.16 μM.",462.56,"1355326-35-0",{"v":24,"d":"24.00"},51.89,"<1","N/A","http://selleckchem.com/products/agi-5198.html","C27H31FN4O2","free base","IDH-C35","CC1=C(C=CC=C1)C(N(C(=O)C[N]2C=CN=C2C)C3=CC(=CC=C3)F)C(=O)NC4CCCCC4",4.354,3,1,7]
["S7217","OAC1","a8","L6600-01","in 10mM DMSO","OCT","Stem Cells & Wnt","OAC1 (Oct4-activating compound 1, BAS 00287861) can enhance the efficiency of reprogramming. OAC1 can activate both Oct4 and Nanog promoter-driven luciferase reporter genes.",237.26,"300586-90-7",{"v":47,"d":"47.00"},198.09,"<1","N/A","http://selleckchem.com/products/oac1.html","C14H11N3O","free base","BAS 00287861","O=C(NC1=CC2=C([NH]C=C2)C=N1)C3=CC=CC=C3",2.296,2,2,2]
["S7230","UNC0642","b8","L6600-01","in 10mM DMSO","G9a/GLP,Histone Methyltransferase","Epigenetics","UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a/GLP with IC50s less than 2.5 nM for G9a and GLP and shows more than 300-fold selective for G9a and GLP over a broad range of kinases, GPCRs, transporters, and ion channels.",{"v":546.7,"d":"546.70"},"1481677-78-4",{"v":100,"d":"100.00"},182.92,"<1","N/A","http://selleckchem.com/products/unc0642.html","C29H44F2N6O2","free base","N/A","COC1=CC2=C(C=C1OCCCN3CCCC3)N=C(N=C2NC4CCN(CC4)C(C)C)N5CCC(F)(F)CC5",4.706,4,1,10]
["S7234","IOX1","c8","L6600-01","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases. IOX1 is an inhibitor of ALKBH5.",189.17,"5852-78-8",{"v":37,"d":"37.00"},195.59,"<1","N/A","http://selleckchem.com/products/iox1.html","C10H7NO3","free base","N/A","OC(=O)C1=CC=C(O)C2=NC=CC=C12",1.404,2,1,1]
["S7237","OG-L002","d8","L6600-01","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.",225.29,"1357302-64-7",{"v":45,"d":"45.00"},199.74,"<1","N/A","http://selleckchem.com/products/og-l002.html","C15H15NO","free base","N/A","NC1CC1C2=CC=C(C=C2)C3=CC=CC(=C3)O",{"v":2.47,"d":"2.470"},0,2,2]
["S7265","MM-102","e8","L6600-01","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MM-102 (HMTase Inhibitor IX) is a high-affinity peptidomimetic inhibitor of the WDR5/MLL1  protein-protein interaction, which bind to WDR5 with Ki < 1 nM and IC50 =2.4nM.",{"v":669.8,"d":"669.80"},"1417329-24-8",{"v":100,"d":"100.00"},{"v":149.3,"d":"149.30"},{"v":100,"d":"100.00"},{"v":149.3,"d":"149.30"},"http://selleckchem.com/products/mm-102.html","C35H49F2N7O4","free base","HMTase Inhibitor IX","CCC(CC)(NC(=O)C(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3",4.419,4,6,17]
["S7276","SGI-1027","f8","L6600-01","in 10mM DMSO","Apoptosis related,DNA Methyltransferase","Epigenetics","SGI-1027 (DNA Methyltransferase Inhibitor II) is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B in cell-free assays, respectively. SGI‑1027 induces apoptosis.",461.52,"1020149-73-8",{"v":92,"d":"92.00"},199.34,"<1","N/A","http://selleckchem.com/products/sgi-1027.html","C27H23N7O","free base","DNA Methyltransferase Inhibitor II","CC1=CC(=NC(=N1)N)NC2=CC=C(NC(=O)C3=CC=C(NC4=CC=NC5=C4C=CC=C5)C=C3)C=C2",4.718,4,4,6]
["S7281","JIB-04","g8","L6600-01","in 10mM DMSO","Apoptosis related,Histone Demethylase,JMJD","Epigenetics","JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively. JIB‑04 also induces cell apoptosis.",308.76,"199596-05-9",{"v":25,"d":"25.00"},80.97,"<1","N/A","http://selleckchem.com/products/jib-04.html","C17H13ClN4","free base","NSC 693627","ClC1=CN=C(N/N=C(C2=CC=CC=C2)/C3=NC=CC=C3)C=C1",4.424,3,1,4]
["S7294","PFI-2 HCl","h8","L6600-01","in 10mM DMSO","Histone Methyltransferase,SETD","Epigenetics","PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.",535.98,"1627607-87-7",{"v":99,"d":"99.00"},184.71,{"v":4,"d":"4.00"},7.46,"http://selleckchem.com/products/pfi-2.html","C23H25F4N3O3S.HCl","Hydrochloride","N/A","FC1=CC(=CC2=C1CNCC2)[S](=O)(=O)NC(CC3=CC=CC(=C3)C(F)(F)F)C(=O)N4CCCC4",3.268,3,2,7]
["S7296","ML324","a9","L6600-01","in 10mM DMSO","CMV,Histone Demethylase,JMJD","Epigenetics","ML324 is a selective inhibitor of jumonji histone demethylase (JMJD2) with IC50 of 920 nM.",349.43,"1222800-79-4",{"v":43,"d":"43.00"},123.06,"<1","N/A","http://selleckchem.com/products/ml324.html","C21H23N3O2","free base","N/A","CN(C)CCCNC(=O)C1=CC=C(C=C1)C2=CC3=CC=CN=C3C(=C2)O",2.701,2,2,6]
["S7298","AZ5104","b9","L6600-01","in 10mM DMSO","EGFR","Protein Tyrosine Kinase","AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.",485.58,"1421373-98-9",{"v":97,"d":"97.00"},199.76,"<1","N/A","http://selleckchem.com/products/az5104.html","C27H31N7O2","free base","N/A","COC1=C(NC2=NC=CC(=N2)C3=C[NH]C4=C3C=CC=C4)C=C(NC(=O)C=C)C(=C1)N(C)CCN(C)C",4.465,4,3,10]
["S7353","EPZ004777","c9","L6600-01","in 10mM DMSO","Apoptosis related,DOT1,Histone Methyltransferase","Epigenetics","EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM in a cell-free assay and demonstrates >1,200-fold selectivity for DOT1L over all other tested PMTs. EPZ004777 induces apoptosis.",539.67,"1338466-77-5",{"v":100,"d":"100.00"},{"v":185.3,"d":"185.30"},"<1","N/A","http://selleckchem.com/products/epz004777.html","C28H41N7O4","free base","N/A","CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2OC(C(O)C2O)[N]3C=CC4=C3N=CN=C4N",2.529,4,5,10]
["S7360","Birabresib (OTX015)","d9","L6600-01","in 10mM DMSO","Epigenetic Reader Domain,NSD","Epigenetics","Birabresib (OTX015, MK 8628) is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays. Birabresib inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.",491.99,"202590-98-5",{"v":98,"d":"98.00"},199.19,"<1","N/A","http://selleckchem.com/products/otx015.html","C25H22ClN5O2S","free base","MK 8628","CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(=O)NC4=CC=C(O)C=C4)N=C2C5=CC=C(Cl)C=C5)C",4.709,4,2,4]
["S7465","FTI 277 HCl","e9","L6600-01","in 10mM DMSO","Anti-infection,Apoptosis related,FTase,Transferase","Metabolism","FTI 277 HCl is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. FTI 277 HCl inhibits cell growth and induces apoptosis. FTI 277 HCl is effective in clearing HDV viremia.",484.07,"180977-34-8",{"v":96,"d":"96.00"},198.32,{"v":17,"d":"17.00"},35.12,"http://selleckchem.com/products/fti-277-hcl.html","C22H30ClN3O3S2","hydrochloride salt","N/A","Cl.COC(=O)C(CCSC)NC(=O)C1=C(C=C(NCC(N)CS)C=C1)C2=CC=CC=C2",2.897,3,3,12]
["S7570","UNC0379","f9","L6600-01","in 10mM DMSO","Histone Methyltransferase,SETD","Epigenetics","UNC0379 is a selective, substrate competitive inhibitor of N-lysine methyltransferase SETD8 with IC50 of 7.3 μM, high selectivity over 15 other methyltransferases.",413.56,"1620401-82-2",{"v":82,"d":"82.00"},198.28,"<1","N/A","http://selleckchem.com/products/unc0379.html","C23H35N5O2","free base","N/A","COC1=C(OC)C=C2C(=NC(=NC2=C1)N3CCCC3)NCCCCCN4CCCC4",4.545,4,1,10]
["S7572","A-366","g9","L6600-01","in 10mM DMSO","G9a/GLP,Histone Methyltransferase","Epigenetics","A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor with IC50 of 3.3nM and 38nM, exhibiting >1000-fold selectivity for G9a/GLP over 21 other methyltransferases.",329.44,"1527503-11-2",{"v":65,"d":"65.00"},{"v":197.3,"d":"197.30"},"<1","N/A","http://selleckchem.com/products/a-366.html","C19H27N3O2","free base","N/A","COC1=C(OCCCN2CCCC2)C=C3N=C(N)C4(CCC4)C3=C1",2.467,3,1,6]
["S7574","GSK-LSD1 2HCl","h9","L6600-01","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B).",289.24,"2102933-95-7",{"v":57,"d":"57.00"},197.07,{"v":57,"d":"57.00"},197.07,"http://selleckchem.com/products/gsk-lsd1-2hcl.html","C14H22Cl2N2","dihydrochloride","N/A","Cl.Cl.C1CC(CCN1)NC2CC2C3=CC=CC=C3",1.964,0,2,3]
["S7575","LLY-507","a10","L6600-01","in 10mM DMSO","Histone Methyltransferase,SMYD","Epigenetics","LLY-507 is a cell-active, potent, and selective inhibitor of protein-lysine Methyltransferase SMYD2.",574.76,"1793053-37-8",{"v":100,"d":"100.00"},173.99,"<1","N/A","http://selleckchem.com/products/lly-507.html","C36H42N6O","free base","N/A","CC1=C[N](CCN2CCN(CC2)C3=CC=CC=C3C4=CC(=CC(=C4)C(=O)NCCCN5CCCC5)C#N)C6=C1C=CC=C6",5.851,1,1,10]
["S7581","GSK J1","b10","L6600-01","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","GSK-J1 is a highly potent inhibitor of H3K27 histone demethylase JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 60 nM  in cell-free assays for JMJD3 (KDM6B) , respectively, >10-fold selectivity over other tested demethylases, with IC50 of 0.95μM and 1.76μM towards JARID1B/C.",389.45,"1373422-53-7",{"v":77,"d":"77.00"},197.71,"<1","N/A","http://selleckchem.com/products/gsk-j1.html","C22H23N5O2","free base","N/A","OC(=O)CCNC1=CC(=NC(=N1)C2=CC=CC=N2)N3CCC4=C(CC3)C=CC=C4",3.707,4,1,6]
["S7591","BRD4770","c10","L6600-01","in 10mM DMSO","G9a/GLP,Histone Methyltransferase","Epigenetics","BRD4770 is a histone methyltransferase G9a inhibitor with IC50 of 6.3 μM, and induces cell senescence.",413.47,"1374601-40-7",{"v":27,"d":"27.00"},{"v":65.3,"d":"65.30"},"<1","N/A","http://selleckchem.com/products/brd4770.html","C25H23N3O3","free base","N/A","COC(=O)C1=CC=C2[N](CCCC3=CC=CC=C3)C(=NC2=C1)NC(=O)C4=CC=CC=C4",5.094,4,1,8]
["S7611","EI1","d10","L6600-01","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.",390.48,"1418308-27-6",{"v":42,"d":"42.00"},107.56,"<1","N/A","http://selleckchem.com/products/ei1.html","C23H26N4O2","free base","N/A","CCC(CC)[N]1C=CC2=C(C=C(C=C12)C#N)C(=O)NCC3=C(C)C=C(C)NC3=O",{"v":3.54,"d":"3.540"},2,2,6]
["S7616","CPI-169","e10","L6600-01","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","CPI-169 is a potent, and selective EZH2 inhibitor with IC50 of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.",528.66,"1450655-76-1",{"v":100,"d":"100.00"},189.16,"<1","N/A","http://selleckchem.com/products/cpi-169.html","C27H36N4O5S","free base","N/A","CC[S](=O)(=O)N1CCC(CC1)C(C)[N]2C(=C(C(=O)NCC3=C(OC)C=C(C)NC3=O)C4=CC=CC=C24)C",{"v":1.74,"d":"1.740"},5,2,8]
["S7618","MI-2 (Menin-MLL Inhibitor)","f10","L6600-01","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.",375.55,"1271738-62-5",{"v":75,"d":"75.00"},199.71,"<1","N/A","http://selleckchem.com/products/mi-2-menin-mll-inhibitor.html","C18H25N5S2","free base","N/A","CCCC1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(C)(C)S4",4.161,3,0,4]
["S7619","MI-3 (Menin-MLL Inhibitor)","g10","L6600-01","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM.",375.55,"1271738-59-0",{"v":19,"d":"19.00"},50.59,"<1","N/A","http://selleckchem.com/products/mi-3-menin-mll-inhibitor.html","C18H25N5S2","free base","N/A","CC(C)C1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(C)(C)S4",4.168,3,0,3]
["S7656","CPI-360","h10","L6600-01","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.",437.53,"1802175-06-9",{"v":20,"d":"20.00"},45.71,"<1","N/A","http://selleckchem.com/products/cpi-360.html","C25H31N3O4","free base","N/A","COC1=C(CNC(=O)C2=C(C)[N](C(C)C3CCOCC3)C4=C2C=CC=C4)C(=O)NC(=C1)C",2.071,4,2,6]
["S7680","SP2509","a11","L6600-01","in 10mM DMSO","Apoptosis related,Autophagy,Histone Demethylase,LSD1","Epigenetics","SP2509 (HCI-2509) is a selective histone demethylase LSD1 inhibitor with IC50 of  13 nM, showing no activity against MAO-A, MAO-B, lactate dehydrogenase and glucose oxidase. SP2509 induces apoptosis and promotes autophagy.",{"v":437.9,"d":"437.90"},"1423715-09-6",{"v":38,"d":"38.00"},86.78,"<1","N/A","http://selleckchem.com/products/sp2509.html","C19H20ClN3O5S","free base","HCI-2509","CC(=N\\NC(=O)C1=CC=CC(=C1)[S](=O)(=O)N2CCOCC2)/C3=CC(=CC=C3O)Cl",1.891,5,2,5]
["S7684","Salirasib","b11","L6600-01","in 10mM DMSO","Autophagy,PPMTase,Ras","Cell Cycle","Salirasib (Farnesylthiosalicylic acid, FTS) is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Salirasib exerts antitumor effects and induces autophagy. Phase 2.",358.54,"162520-00-5","The physical form of the compound is fat, and can be dissolved in any proportion in DMSO","N/A","N/A","N/A","http://selleckchem.com/products/salirasib.html","C22H30O2S","free base","Farnesylthiosalicylic acid, FTS","CC(C)=CCC/C(C)=C/CC/C(C)=C/CSC1=CC=CC=C1C(O)=O",{"v":7.12,"d":"7.120"},1,0,10]
["S7723","PRIMA-1","c11","L6600-01","in 10mM DMSO","p53","Apoptosis","PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.",185.22,"5608-24-2",{"v":37,"d":"37.00"},199.76,{"v":37,"d":"37.00"},199.76,"http://selleckchem.com/products/prima-1.html","C9H15NO3","free base","2,2-Bis(hydroxymethyl)-3-quinuclidinone","OCC1(CO)N2CCC(CC2)C1=O",-0.772,1,2,2]
["S7748","EPZ015666 (GSK3235025)","d11","L6600-01","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","EPZ015666 (GSK3235025) is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.",383.44,"1616391-65-1",{"v":60,"d":"60.00"},156.48,"<1","N/A","http://selleckchem.com/products/epz015666.html","C20H25N5O3","free base","GSK3235025","OC(CNC(=O)C1=CC(=NC=N1)NC2COC2)CN3CCC4=C(C3)C=CC=C4",1.038,4,3,7]
["S7795","Iadademstat (ORY-1001) 2HCl","e11","L6600-01","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","ORY-1001 (RG-6016) 2HCl is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.",303.27,"1431326-61-2",{"v":5,"d":"5.00"},16.49,{"v":61,"d":"61.00"},201.14,"http://selleckchem.com/products/ory-1001-rg-6016.html","C15H22N2.2HCl","dihydrochloride","RG-6016","Cl.Cl.NC1CCC(CC1)NC2CC2C3=CC=CC=C3",2.721,0,2,3]
["S7796","GSK2879552 2HCl","f11","L6600-01","in 10mM DMSO","Histone Demethylase,LSD1","Epigenetics","GSK2879552 2HCl is a potent, selective, orally bioavailable, irreversible LSD1 inhibitor with Kiapp of 1.7 μM. Phase 1.",{"v":437.4,"d":"437.40"},"1902123-72-1",{"v":29,"d":"29.00"},{"v":66.3,"d":"66.30"},{"v":44,"d":"44.00"},100.59,"http://selleckchem.com/products/gsk2879552-2hcl.html","C23H28N2O2.2HCl","dihydrochloride","N/A","Cl.Cl.OC(=O)C1=CC=C(CN2CCC(CC2)CNC3CC3C4=CC=CC=C4)C=C1",1.586,1,1,7]
["S7804","GSK503","g11","L6600-01","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","GSK503 is a potent and specific EZH2 methyltransferase inhibitor.",526.67,"1346572-63-1",{"v":100,"d":"100.00"},189.87,"<1","N/A","http://selleckchem.com/products/gsk503.html","C31H38N6O2","free base","N/A","CC(C)[N]1C=C(C)C2=C1C=C(C=C2C(=O)NCC3=C(C)C=C(C)NC3=O)C4=CC=C(N=C4)N5CCN(C)CC5",4.126,3,2,6]
["S7815","MI-136","h11","L6600-01","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-136  can specifically inhibit the menin-MLL interaction. It inhibits DHT-induced expression of androgen receptor (AR) target genes.",470.51,"1628316-74-4",{"v":94,"d":"94.00"},199.78,"<1","N/A","http://selleckchem.com/products/mi-136.html","C23H21F3N6S","free base","N/A","FC(F)(F)CC1=CC2=C(NC3CCN(CC3)CC4=CC=C5[NH]C(=CC5=C4)C#N)N=CN=C2S1",4.886,2,2,6]
["S7816","MI-463","a2","L6600-02","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-463 is a potent inhibitor of Menin-MLL interaction with an IC50 value of 15.3 nM.",484.54,"1628317-18-9",{"v":96,"d":"96.00"},198.13,"<1","N/A","http://selleckchem.com/products/mi-463.html","C24H23F3N6S","free base","N/A","CC1=C2C=C([NH]C2=CC=C1CN3CCC(CC3)NC4=C5C=C(CC(F)(F)F)SC5=NC=N4)C#N",5.372,2,2,6]
["S7820","EPZ020411 2HCl","b2","L6600-02","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","EPZ020411 is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM.",515.52,"2070015-25-5",{"v":100,"d":"100.00"},193.98,{"v":81,"d":"81.00"},157.12,"http://selleckchem.com/products/epz020411.html","C25H40Cl2N4O3","dihydrochloride","N/A","Cl.Cl.CNCCN(C)CC1=C[NH]N=C1C2=CC=C(OC3CC(C3)OCCC4CCOCC4)C=C2",3.322,4,2,12]
["S7832","SGC707","c2","L6600-02","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively.",298.34,"1687736-54-4",{"v":59,"d":"59.00"},197.76,"<1","N/A","http://selleckchem.com/products/sgc707.html","C16H18N4O2","free base","N/A","O=C(NCC(=O)N1CCCC1)NC2=CC3=CC=NC=C3C=C2",{"v":0.43,"d":"0.430"},3,2,3]
["S7833","OICR-9429","d2","L6600-02","in 10mM DMSO","Histone Methyltransferase,WDR5","Epigenetics","OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. It binds to WDR5 with high affinity (KD = 93 ± 28 nM.",555.59,"1801787-56-3",{"v":38,"d":"38.00"},{"v":68.4,"d":"68.40"},"<1","N/A","http://selleckchem.com/products/oicr-9429.html","C29H32F3N5O3","free base","N/A","CN1CCN(CC1)C2=CC=C(C=C2NC(=O)C3=CNC(=O)C=C3C(F)(F)F)C4=CC(=CC=C4)CN5CCOCC5",2.722,3,2,7]
["S7884","AMI-1","e2","L6600-02","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","AMI-1 is a potent and specific Histone Methyltransferase (HMT) inhibitor with IC50 of 3.0 μM and 8.8 μM for yeast Hmt1p and human PRMT1, respectively.",548.45,"20324-87-2",{"v":100,"d":"100.00"},182.33,{"v":10,"d":"10.00"},18.23,"http://selleckchem.com/products/ami-1.html","C21H14N2Na2O9S2","disodium salt","N/A","OC1=C2C=CC(=CC2=CC(=C1)[S](=O)(=O)O[Na])NC(=O)NC3=CC=C4C(=CC(=CC4=C3)[S](=O)(=O)O[Na])O",2.703,3,4,6]
["S7983","A-196","f2","L6600-02","in 10mM DMSO","Histone Methyltransferase,SETD","Epigenetics","A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over other histone methyltransferases and non-epigenetic targets.",359.25,"1982372-88-2",{"v":15,"d":"15.00"},41.75,"<1","N/A","http://selleckchem.com/products/a-196.html","C18H16Cl2N4","free base","N/A","ClC1=C(Cl)C=C2C(=C1)C(=NN=C2C3=CC=NC=C3)NC4CCCC4",4.995,3,1,3]
["S8006","BIX 01294","g2","L6600-02","in 10mM DMSO","Autophagy,G9a/GLP,Histone Methyltransferase,NSD","Epigenetics","BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3.",600.02,"1392399-03-9",{"v":98,"d":"98.00"},163.33,{"v":98,"d":"98.00"},163.33,"http://selleckchem.com/products/bix-01294.html","C28H38N6O2.3HCl","trihydrochloride","N/A","Cl.Cl.Cl.COC1=CC2=NC(=NC(=C2C=C1OC)NC3CCN(CC3)CC4=CC=CC=C4)N5CCCN(C)CC5",5.246,4,1,7]
["S8056","Lomeguatrib","h2","L6600-02","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Lomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.",326.17,"192441-08-0",{"v":65,"d":"65.00"},199.28,"<1","N/A","http://selleckchem.com/products/lomeguatrib.html","C10H8BrN5OS","free base","PaTrin-2","NC1=NC2=C([NH]C=N2)C(=N1)OCC3=CC(=CS3)Br",2.131,4,2,3]
["S8068","Chaetocin","a3","L6600-02","in 10mM DMSO","Anti-infection,G9a/GLP,Histone Methyltransferase,Thioredoxin Reductase","Epigenetics","Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively. Chaetocin is an anticancer agent and inhibitor of thioredoxin reductase (TrxR).",696.84,"28097-03-2",{"v":100,"d":"100.00"},{"v":143.5,"d":"143.50"},"<1","N/A","http://selleckchem.com/products/chaetocin.html","C30H28N6O6S4","free base","N/A","CN1C(=O)C23CC4(C(NC5=C4C=CC=C5)N2C(=O)C1(CO)SS3)C67CC89SSC(CO)(N(C)C8=O)C(=O)N9C6NC%10=C7C=CC=C%10",1.621,4,4,3]
["S8071","UNC0638","b3","L6600-02","in 10mM DMSO","Antiviral,G9a/GLP,Histone Methyltransferase","Epigenetics","UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities.",509.73,"1255580-76-7",{"v":100,"d":"100.00"},196.18,{"v":6,"d":"6.00"},11.77,"http://selleckchem.com/products/unc0638.html","C30H47N5O2","free base","N/A","COC1=CC2=C(NC3CCN(CC3)C(C)C)N=C(N=C2C=C1OCCCN4CCCC4)C5CCCCC5",5.284,4,1,10]
["S8111","GSK591","c3","L6600-02","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","GSK591 (EPZ015866, GSK3203591) is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 4 nM.",380.48,"1616391-87-7",{"v":76,"d":"76.00"},199.75,"<1","N/A","http://selleckchem.com/products/gsk591-epz015866-gsk3203591.html","C22H28N4O2","free base","EPZ015866, GSK3203591","OC(CNC(=O)C1=CC(=NC=C1)NC2CCC2)CN3CCC4=C(C3)C=CC=C4",2.467,2,3,7]
["S8112","MS023","d3","L6600-02","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.",{"v":287.4,"d":"287.40"},"1831110-54-3",{"v":57,"d":"57.00"},198.33,"<1","N/A","http://selleckchem.com/products/ms023.html","C17H25N3O","free base","N/A","CC(C)OC1=CC=C(C=C1)C2=C[NH]C=C2CN(C)CCN",2.396,1,2,7]
["S8147","MS049","e3","L6600-02","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","MS049 is a potent and selective inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively.",321.29,"2095432-59-8",{"v":56,"d":"56.00"},{"v":174.3,"d":"174.30"},{"v":56,"d":"56.00"},{"v":174.3,"d":"174.30"},"http://selleckchem.com/products/ms049.html","C15H26Cl2N2O","dihydrochloride","N/A","Cl.Cl.CNCCN1CCC(CC1)OCC2=CC=CC=C2",2.111,1,1,6]
["S8205","Enasidenib (AG-221)","f3","L6600-02","in 10mM DMSO","Dehydrogenase","Metabolism","Enasidenib (AG-221) is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzyme.",473.38,"1446502-11-9",{"v":94,"d":"94.00"},198.57,"<1","N/A","http://selleckchem.com/products/ag-221-enasidenib.html","C19H17F6N7O","free base","N/A","CC(C)(O)CNC1=NC(=NC(=N1)NC2=CC=NC(=C2)C(F)(F)F)C3=NC(=CC=C3)C(F)(F)F",4.878,5,2,8]
["S8209","HLCL-61 HCL","g3","L6600-02","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.",380.91,"1158279-20-9",{"v":76,"d":"76.00"},199.52,"<1","N/A","http://selleckchem.com/products/hlcl-61-hydrochloride.html","C23H24N2O.HCl","hydrochloride","HLCL61","Cl.CC[N]1C2=CC=CC=C2C3=C1C=CC(=C3)CNCC4=C(OC)C=CC=C4",5.364,1,1,6]
["S8287","CPI-455 HCl","h3","L6600-02","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","CPI-455  HCl is a specific KDM5 inhibitor with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.",314.77,"2095432-28-1",{"v":10,"d":"10.00"},31.77,"<1","N/A","https://www.selleckchem.com/products/cpi-455-hcl.html","C16H15ClN4O","hydrochloride","N/A","Cl.CC(C)C1=C(NC2=C(C=N[N]2C1=O)C#N)C3=CC=CC=C3",3.195,2,1,2]
["S8340","SGC2085","a4","L6600-02","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","SGC2085 is a potent and selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) inhibitor with an IC50 value of 50 nM and >100-fold selective over other PRMTs.",312.41,"1821908-48-8",{"v":62,"d":"62.00"},198.46,"<1","N/A","http://selleckchem.com/products/sgc2085.html","C19H24N2O2","free base","N/A","CC(N)C(=O)NCC1=CC=C(OC2=CC(=CC(=C2)C)C)C(=C1)C",3.498,2,2,5]
["S8353","Lirametostat (CPI-1205)","b4","L6600-02","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","Lirametostat (CPI-1205) is an orally available selective inhibitor of the histone lysine methyltransferase EZH2 with IC50 values of 2 nM and 52 nM for EZH2 and EZH1 respectively. It has potential antineoplastic activity.",518.57,"1621862-70-1",{"v":100,"d":"100.00"},192.84,"<1","N/A","http://selleckchem.com/products/cpi-1205.html","C27H33F3N4O3","free base","CPI 1205, CPI1205","COC1=C(CNC(=O)C2=C(C)[N](C(C)C3CCN(CC3)CC(F)(F)F)C4=C2C=CC=C4)C(=O)NC(=C1)C",3.348,3,2,8]
["S8359","UNC3866","c4","L6600-02","in 10mM DMSO","Histone Methyltransferase","Epigenetics","UNC3866 is a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains. UNC3866 binds the chromodomains of CBX4 and CBX7 most potently, with a K(d) of ∼100 nM for each, and is 6- to 18-fold selective as compared to seven other CBX and CDY chromodomains.",795.02,"1872382-47-2",{"v":100,"d":"100.00"},125.78,"<1","N/A","http://selleckchem.com/products/unc3866.html","C43H66N6O8","free base","N/A","CCN(CC)CCCCC(NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C(=O)NC(CO)C(=O)OC",4.291,7,6,25]
["S8438","T-3775440 HCl","d4","L6600-02","in 10mM DMSO","Histone Demethylase,LSD1","Methylation","T-3775440 HCl is an irreversible LSD1 inhibitor that is highly selective for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B), with an IC50 value of 2.1 nmol/L.",346.85,"1422535-52-1",{"v":69,"d":"69.00"},198.93,{"v":22,"d":"22.00"},63.43,"http://www.selleck.cn/products/t-3775440-hcl.html","C18H23ClN4O","HCl","N/A","Cl.C[N]1C=C(C=N1)C(=O)NC2=CC=C(C=C2)C3CC3NCC4CC4",2.262,2,2,6]
["S8479","LLY-284","e4","L6600-02","in 10mM DMSO","PRMT","Epigenetics","LLY-284 is the diastereomer of LLY-283, which is a potent and selective SAM-competitive chemical probe for PRMT5. LLY-284 is much less active than LLY-283 and can be used as a negative control for LLY-283.",342.35,"2226515-75-7",{"v":68,"d":"68.00"},198.63,"<1","N/A","https://www.selleckchem.com/products/lly-284.html","C17H18N4O4","free base","N/A","NC1=NC=NC2=C1C=C[N]2C3OC(C(O)C3O)C(O)C4=CC=CC=C4",0.509,3,4,3]
["S8494","PF-06726304","f4","L6600-02","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","PF-06726304 is a selective EZH2 inhibitor with Ki values of 0.7 nM and 3 nM for WT EZH2 and Y641N respectively; also inhibits H3K27me3 with the IC50 value of 15 nM.",446.33,"1616287-82-1",{"v":10,"d":"10.00"},{"v":22.4,"d":"22.40"},"<1","N/A","http://selleckchem.com/products/pf-06726304.html","C22H21Cl2N3O3","free base","PF-6726304","CC1=CC(=C(CN2CCC3=C(Cl)C=C(C(=C3C2=O)Cl)C4=C(C)ON=C4C)C(=O)N1)C",3.398,4,1,3]
["S8496","EED226","g4","L6600-02","in 10mM DMSO","Epigenetic Reader Domain,Histone Methyltransferase","Epigenetics","EED226 is a potent, selective, and orally bioavailable a novel allosteric Polycomb repressive complex 2 (PRC2) inhibitor with an IC50 of 23.4 nM when the H3K27me0 peptide was used as substrate and an IC50 of 53.5 nM when the mononucleosome was used as the substrate. It directly binds to the H3K27me3 binding pocket of EED.",{"v":369.4,"d":"369.40"},"2083627-02-3",{"v":73,"d":"73.00"},197.62,"<1","N/A","http://selleckchem.com/products/eed226.html","C17H15N5O3S","free base","N/A","C[S](=O)(=O)C1=CC=C(C=C1)C2=CN=C(NCC3=CC=CO3)[N]4C=NN=C24",2.136,6,1,5]
["S8607","JQ-EZ-05 (JQEZ5)","h4","L6600-02","in 10mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","JQ-EZ-05 (JQEZ5) is a specific and reversible EZH1/2 inhibitor.",542.68,"1913252-04-6",{"v":24,"d":"24.00"},44.22,"N/A","N/A","http://selleckchem.com/products/jq-ez-05-jqez5.html","C30H38N8O2","free base","N/A","CCCC1=C(CNC(=O)C2=CC(=NC3=C2C=N[N]3C(C)C)C4=CC=C(N=C4)N5CCN(C)CC5)C(=O)NC(=C1)C",3.379,5,2,8]
["S8608","Adenosine Dialdehyde (ADOX)","a5","L6600-02","in 10mM DMSO","SAM MTase,Transferase","Metabolism","Adenosine Dialdehyde (ADOX) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.",265.23,"34240-05-6",{"v":19,"d":"19.00"},71.64,{"v":3,"d":"3.00"},11.31,"http://selleckchem.com/products/adenosine-dialdehyde-adox.html","C10H11N5O4","free base","N/A","NC1=NC=NC2=C1N=C[N]2C(OC(CO)C=O)C=O",-1.346,6,2,6]
["S8664","Pemrametostat (GSK3326595)","b5","L6600-02","in 10mM DMSO","Histone Methyltransferase,PRMT","Epigenetics","Pemrametostat (GSK3326595, EPZ015938) is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) and potently inhibits tumor growth in vitro and in vivo in animal models.",452.55,"1616392-22-3",{"v":90,"d":"90.00"},198.87,"<1","N/A","http://selleckchem.com/products/gsk3326595-epz015938.html","C24H32N6O3","free base","EPZ015938","CC(=O)N1CCC(CC1)NC2=CC(=NC=N2)C(=O)NCC(O)CN3CCC4=C(C3)C=CC=C4",0.692,4,3,7]
["S9031","Gambogenic acid","c5","L6600-02","in 10mM DMSO","EZH1/2,FGFR","Angiogenesis","Gambogenic Acid, identified from Gamboge, is an inhibitor of the FGFR signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC) and exhibits anti-tumor effects. Gambogenic acid acts is also an effective inhibitor of EZH2 that specifically and covalently binds to Cys668 within the EZH2-SET domain, and triggers EZH2 ubiquitination.",630.77,"173932-75-7",{"v":10,"d":"10.00"},15.85,"N/A","N/A","https://www.selleckchem.com/products/gambogenic-acid.html","C38H46O8","free base","N/A","CC(C)=CCC/C(C)=C/CC1=C(O)C2=C(OC34C5CC(C=C3C2=O)C(=O)C4(C\\C=C(\\C)C(O)=O)OC5(C)C)C(=C1O)CC=C(C)C",7.717,5,2,10]
["S9227","Sinensetin","d5","L6600-02","in 10mM DMSO","Others","Others","Sinensetin (Pedalitin Permethyl ether), a natural polymethoxylated flavone, has potent antiangiogenesis activity.",372.37,"2306-27-6",{"v":27,"d":"27.00"},72.51,"N/A","N/A","https://www.selleckchem.com/products/sinensetin.html","C20H20O7","free base","Pedalitin Permethyl ether","COC1=CC=C(C=C1OC)C2=CC(=O)C3=C(O2)C=C(OC)C(=C3OC)OC",3.054,7,0,6]
["S9287","Genkwanin","e5","L6600-02","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Genkwanin (Apigenin 7-methyl ether) is one of the major non-glycosylated flavonoids in herbs. It has a variety of pharmacological effects including anti-inflammatory, anti-bacterial, antiplasmodial, radical scavenging, chemopreventive and inhibiting 17β-Hydroxysteroid dehydrogenase type 1 activities.",284.26,"437-64-9",{"v":57,"d":"57.00"},200.52,"N/A","N/A","https://www.selleckchem.com/products/genkwanin.html","C16H12O5","free base","Apigenin 7-methyl ether","COC1=CC2=C(C(=C1)O)C(=O)C=C(O2)C3=CC=C(O)C=C3",2.636,3,2,2]
["S9328","5,6,7-Trimethoxyflavone","f5","L6600-02","in 10mM DMSO","Antiviral,Bacterial","Microbiology","5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.",312.32,"973-67-1",{"v":10,"d":"10.00"},32.02,"N/A","N/A","https://www.selleckchem.com/products/trimethoxyflavone.html","C18H16O5","free base","Baicalein Trimethyl Ether","COC1=CC2=C(C(=O)C=C(O2)C3=CC=CC=C3)C(=C1OC)OC",3.087,5,0,4]
["S9472","Oxtriphylline","g5","L6600-02","in 10mM DMSO","PDE Inhibitor, Adenosine receptor, & Histone deacetylase","Metabolism","Oxtriphylline is a choline salt of theophylline with anti-asthmatic activity (bronchodilator). The theophylline, upon release, acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator.",283.33,"4499-40-5",{"v":15,"d":"15.00"},52.94,{"v":-1,"d":"-1.00"},"N/A","N/A","C12H21N5O3","Free Base","N/A","CN1C(=O)N(C)C2=C([N-]C=N2)C1=O.C[N+](C)(C)CCO",-1.714,3,1,2]
["S6737","C7280948","h5","L6600-02","in 10mM DMSO","PRMT","Methylation","C7280948 is a protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 12.8 μM in vitro.",276.35,"587850-67-7",{"v":55,"d":"55.00"},199.02,"<1","N/A","http://www.selleck.cn/products/c7280948.html","C14H16N2O2S","Free Base","N/A","NC1=CC=C(C=C1)[S](=O)(=O)NCCC2=CC=CC=C2",1.899,2,2,5]
["S1059","KDM4D-IN-1","a6","L6600-02","in 10mM DMSO","Histone Demethylase","Epigenetics","KDM4D-IN-1 is a potent inhibitor of KDM4D with an IC50 of 0.41 μM.",225.21,"2098902-68-0",{"v":6,"d":"6.00"},26.64,"<1","N/A","http://www.selleck.cn/products/kdm4d-in1.html","C11H7N5O","Free Base","N/A","CC1=N[N]2C(=C1C#N)NC(=O)C3=CC=CN=C23",0.685,3,1,0]
["S2184","WDR5-0103","b6","L6600-02","in 10mM DMSO","Histone Methyltransferase,WDR5","Epigenetics","WDR5-0103 (WD-Repeat Protein 5-0103) is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM.",383.44,"890190-22-4",{"v":77,"d":"77.00"},200.81,"<1","N/A","http://www.selleck.cn/products/wdr5-0103.html","C21H25N3O4","Free Base","WD-Repeat Protein 5-0103","COC(=O)C1=CC=C(N2CCN(C)CC2)C(=C1)NC(=O)C3=CC=CC(=C3)OC",2.573,4,1,6]
["S8812","CM272","c6","L6600-02","in 10mM DMSO","DNA Methyltransferase","Epigenetics","CM-272 is a novel first-in-class dual reversible inhibitor of G9a (GLP) and DNMTs with IC50 of 8 nM, 382 nM, 85 nM, 1200 nM, 2 nM for G9a, DNMT1, DNMT3A, DNMT3B, GLP, respectively. CM-272 prolongs survival in in vivo models of haematological malignancies by at least in part inducing immunogenic cell death.",478.63,"1846570-31-7",{"v":96,"d":"96.00"},200.57,"<1","N/A","http://www.selleck.cn/products/cm272-cm-272.html","C28H38N4O3","Free Base","N/A","COC1=C(OCCCN2CCCC2)C=C3N=C(C=C(NC4CCN(C)CC4)C3=C1)C5=CC=C(C)O5",4.052,4,1,9]
["S0184","XY1","d6","L6600-02","in 10mM DMSO","PRMT","Methylation","XY1 is an inactive, close analog of SGC707 that can be used as the negative control for SGC707. SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 and Kd of 31 nM and 53 nM, respectively.",297.35,"1624117-53-8",{"v":59,"d":"59.00"},198.42,"˂1","N/A","http://www.selleckchem.com/products/xy1.html","C17H19N3O2","Free Base","N/A","O=C(NCC(=O)N1CCCC1)NC2=CC=C3C=CC=CC3=C2",1.581,2,2,3]
["S2477","2'-Deoxy-5-Fluorocytidine","e6","L6600-02","in 10mM DMSO","DNA Methyltransferase","Endocrinology & Hormones","2'-Deoxy-5-fluorocytidine (5-fluoro-2(')-deoxycytidine, FCdR), a pyrimidine analog, is a DNA methyltransferase (DMNT) inhibitor currently in clinical trials for solid tumors.",245.21,"10356-76-0",{"v":49,"d":"49.00"},199.83,{"v":12,"d":"12.00"},48.94,"http://www.selleckchem.com/products/2-feoxy-5-fluorocytidine.html","C9H12FN3O4","Free Base","5-fluoro-2(')-deoxycytidine, FCdR","NC1=NC(=O)N(C=C1F)C2CC(O)C(CO)O2",{"v":-1.72,"d":"-1.720"},3,3,2]
["S6722","Seclidemstat (SP-2577)","f6","L6600-02","in 10mM DMSO","LSD1","Methylation","Seclidemstat (SP-2577) is a potent and orally bioavailable inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with IC50 of 13 nM. Seclidemstat (SP-2577) has potential antineoplastic activity.",450.94,"1423715-37-0",{"v":90,"d":"90.00"},199.58,"˂1","N/A","http://www.selleckchem.com/products/seclidemstat.html","C20H23ClN4O4S","Free Base","SP-2577 mesylate","CN1CCN(CC1)[S](=O)(=O)C2=CC=CC(=C2)C(=O)N\\N=C(C)\\C3=C(O)C=CC(=C3)Cl",{"v":2.16,"d":"2.160"},4,2,5]
["S6779","JBSNF-000088","g6","L6600-02","in 10mM DMSO","NNMT","Methylation","JBSNF-000088 (6-Methoxynicotinamide), an analog of nicotinamide (NA), is a potent inhibitor of Nicotinamide N-methyltransferase (NNMT) with IC50 of 1.8 µM, 2.8 µM, and 5.0 µM for human NNMT(hNNMT), monkey NNMT (mkNNMT) and mouse NNMT (mNNMT), respectively.",152.15,"7150-23-4",{"v":30,"d":"30.00"},197.17,{"v":2,"d":"2.00"},13.14,"http://www.selleckchem.com/products/jbsnf-000088.html","C7H8N2O2","Free Base","6-Methoxynicotinamide","COC1=CC=C(C=N1)C(N)=O",0.204,3,1,2]
["S6833","BCI-121","h6","L6600-02","in 10mM DMSO","SMYD","Methylation","BCI-121 is a potent inhibitor of SMYD3 that impairs the proliferation of many kinds of cancer cells.",340.22,"432529-82-3",{"v":68,"d":"68.00"},199.87,"˂1","N/A","http://www.selleckchem.com/products/bcl-121.html","C14H18BrN3O2","Free Base","N/A","NC(=O)C1CCN(CC1)CC(=O)NC2=CC=C(Br)C=C2",1.179,2,2,4]
["S8883","LLY-283","a7","L6600-02","in 10mM DMSO","PRMT","Methylation","LLY-283 is a novel and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). LLY-283 inhibits PRMT5 enzymatic activity in vitro and in cells with IC50 of 22 nM and 25 nM, respectively. LLY-283 shows antitumor activity.",342.35,"2040291-27-6",{"v":68,"d":"68.00"},198.63,{"v":5,"d":"5.00"},{"v":14.6,"d":"14.60"},"http://www.selleckchem.com/products/lly-283.html","C17H18N4O4","Free Base","N/A","NC1=NC=NC2=C1C=C[N]2C3OC(C(O)C3O)C(O)C4=CC=CC=C4",0.509,3,4,3]
["S0201","Z-JIB-04 (NSC 693627)","b7","L6600-02","in 10mM DMSO","Histone Demethylase,JMJD","Epigenetics","Z-JIB-04 (NSC 693627, JIB-04 Z-isomer) is an isomer of JIB-04. JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230 nM, 340 nM, 855 nM, 445 nM, 435 nM, 1100 nM and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.",308.76,"199596-24-2",{"v":8,"d":"8.00"},25.91,"<1","N/A","http://www.selleckchem.com/products/z-jib-04-nsc-693627.html","C17H13ClN4","free base","JIB-04 Z-isomer, (Z)-JIB-04","ClC1=CN=C(N\\N=C(\\C2=CC=CC=C2)C3=CC=CC=N3)C=C1",4.424,3,1,4]
["S8837","FB23-2","c7","L6600-02","in 10mM DMSO","FTO","Methylation","FB23-2 is a potent and selective FTO inhibitor that directly binds to FTO and selectively inhibits FTO's N6-methyladenosine (m6A) demethylase activity with IC50 of 2.6 μM.",392.24,"2243736-45-8",{"v":78,"d":"78.00"},198.86,"<1","N/A","http://www.selleckchem.com/products/fb23-2.html","C18H15Cl2N3O3","free base","N/A","CC1=C(C(=NO1)C)C2=CC(=C(NC3=CC=CC=C3C(=O)NO)C(=C2)Cl)Cl",4.124,3,2,4]
["S8918","MS1943","d7","L6600-02","in 10mM DMSO","Histone Methyltransferase","Epigenetics","MS1943 is an orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells with IC50 of 120 nM for inhibiting EZH2 methyltransferase activity.",718.93,"2225938-17-8",{"v":100,"d":"100.00"},{"v":139.1,"d":"139.10"},"<1","N/A","http://www.selleckchem.com/products/ms1943.html","C42H54N8O3","free base","N/A","CC(C)[N]1N=CC2=C1C=C(C=C2C(=O)NCC3=C(C)C=C(C)NC3=O)C4=CN=C(C=C4)N5CCN(CCNC(=O)CC67CC8CC(CC(C8)C6)C7)CC5",4.773,5,3,11]
["S7868","S-Adenosyl-L-homocysteine (SAH)","e7","L6600-02","in 10mM DMSO","Histone Methyltransferase","Epigenetics","S-Adenosyl-L-homocysteine (SAH, S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine) is an inhibitor for (Methyltransferase Like 3-14) METTL3-METTL14 heterodimer complex (METTL3-14) with IC50 of 0.9 μM.",384.41,"979-92-0",{"v":77,"d":"77.00"},200.31,"<1","N/A","https://www.selleckchem.com/products/s-adenosyl-l-homocysteine.html","C14H20N6O5S","Free Base","S-Adenosylhomocysteine, AdoHcy, Formycinylhomocysteine","NC(CCSCC1OC(C(O)C1O)[N]2C=NC3=C2N=CN=C3N)C(O)=O",-4.356,5,4,7]
["S0855","TC-E 5003","f7","L6600-02","in 10mM DMSO","AP-1,PRMT","Metabolism","TC-E 5003 (NSC 30176, Compound 2e) is a selective inhibitor of protein arginine methyltransferase 1 (PRMT1) with IC50 of 1.5 μM. TC-E 5003 modulates the lipopolysaccharide (LPS)-induced AP-1 and NF-κB signaling pathways and can possibly be further developed as an anti-inflammatory compound.",401.26,"17328-16-4",{"v":80,"d":"80.00"},199.37,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/tc-e-5003.html","C16H14Cl2N2O4S","Free Base","NSC 30176","ClCC(=O)NC1=CC=C(C=C1)[S](=O)(=O)C2=CC=C(NC(=O)CCl)C=C2",2.238,4,2,6]
["S2971","SIBA","g7","L6600-02","in 10mM DMSO","Others","Others","SIBA (5′-Isobutylthio-5′-deoxyadenosine, 5'-Deoxy-5'-isobutylthioadenosine, 5'-Isobutylthioadenosine) is a synthetic analogue of S-adenosylhomocysteine and is a powerful antipro-liferative drug. SIBA is not only an inhibitor of transmethylation but also interferes with polyamine biosynthesis, probably by blocking aminopropyltransferase.",339.41,"35899-54-8",{"v":68,"d":"68.00"},200.35,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/siba.html","C14H21N5O3S","Free Base","5′-Isobutylthio-5′-deoxyadenosine, 5'-Deoxy-5'-isobutylthioadenosine, 5'-Isobutylthioadenosine","CC(C)CSCC1OC(C(O)C1O)[N]2C=NC3=C(N)N=CN=C23",0.464,4,3,5]
["S6291","FB23","h7","L6600-02","in 10mM DMSO","FTO","Methylation","FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.",377.22,"2243736-35-6",{"v":38,"d":"38.00"},100.74,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/fb23.html","C18H14Cl2N2O3","Free Base","N/A","CC1=C(C(=NO1)C)C2=CC(=C(NC3=CC=CC=C3C(O)=O)C(=C2)Cl)Cl",4.739,3,1,4]
["S8996","Revumenib","a8","L6600-02","in 10mM DMSO","MLL","Epigenetics","Revumenib(SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with a Ki of 0.15 nM. SNDX-5613 shows anti-proliferative activity against multiple cell lines harboring MLLr translocations (MV4;11, RS4;11, MOLM-13, KOPN-8) with IC50 values ranging from 10-20 nM.",630.82,"2169919-21-3",{"v":25,"d":"25.00"},39.63,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/sndx-5613.html","C32H47FN6O4S","Free Base","SNDX-5613","CCN(C(C)C)C(=O)C1=C(OC2=CN=CN=C2N3CC4(CCN(CC4)CC5CCC(CC5)N[S](=O)(=O)CC)C3)C=CC(=C1)F",{"v":4.06,"d":"4.060"},6,1,11]
["S9870","STM2457","b8","L6600-02","in 10mM DMSO","Transferase","Metabolism","STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50  of 16.9 nM. STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases.",444.53,"2499663-01-1",{"v":89,"d":"89.00"},200.21,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/stm2457.html","C25H28N6O2","Free Base","N/A","O=C(NCC1=C[N]2C=C(CNCC3CCCCC3)C=CC2=N1)C4=CC(=O)N5C=CC=CC5=N4",1.465,4,2,7]
["S9882","PFI-90","c8","L6600-02","in 10mM DMSO","Histone Demethylase","Epigenetics","PFI-90 is a selective inhibitor of the histone demethylase KDM3B. PFI-90 induces apoptosis and cell differentiation resulting in delayed tumor progression in vivo.",214.22,"53995-62-3",{"v":43,"d":"43.00"},200.73,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/pfi-90.html","C11H10N4O","Free Base","N/A","O=C(NNC1=NC=CC=C1)C2=NC=CC=C2",1.303,3,2,3]
["E0027","5-Hydroxymethylcytosine","d8","L6600-02","in 10mM DMSO","Others","Epigenetics","5-Hydroxymethylcytosine (5hmC) is a naturally existing component in mammalian genomic DNA and is regarded as the sixth DNA base. 5-Hydroxymethylcytosine is an intermediate metabolite in active DNA demethylation. 5-Hydroxymethylcytosine is epigenetic marks known to affect global gene expression in mammals.",141.13,"1123-95-1",{"v":28,"d":"28.00"},{"v":198.4,"d":"198.40"},"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/5-hydroxymethylcytosine.html","C5H7N3O2","Free Base","5hmC","NC1=C(CO)C=NC(=O)N1",-1.172,2,3,1]
["S6389","CPI-455","e8","L6600-02","in 10mM DMSO","Histone Demethylase","Epigenetics","CPI-455 is a specific KDM5 inhibitor with an IC50 of 10 nM for full-length KDM5A in enzymatic assays. CPI-455 shows over 200-fold selectivity for KDM5 relative to KDM2, 3, 4, 6, and 7 enzymes.",278.31,"1628208-23-0",{"v":56,"d":"56.00"},201.21,"<1","N/A","http://www.selleckchem.com/products/cpi-455.html","C16H14N4O","Free Base","N/A","CC(C)C1=C(NC2=C(C=N[N]2C1=O)C#N)C3=CC=CC=C3",{"v":2.81,"d":"2.810"},2,1,2]
["S9876","Dac51","f8","L6600-02","in 10mM DMSO","FTO","Methylation","Dac51 is a potent FTO inhibitor with an IC50 of 0.4 μM for inhibiting FTO demethylation.",505.27,"2243944-92-3 (free base)",{"v":100,"d":"100.00"},197.91,"<1","N/A","http://www.selleckchem.com/products/dac51.html","C20H17Cl2F3N4O4","Free Base","N/A","CC1=C(C(=N[NH]1)C)C2=CC(=C(NC3=CC=CC=C3C(=O)NO)C(=C2)Cl)Cl.OC(=O)C(F)(F)F",{"v":5,"d":"5.000"},3,3,5]
["E0133","NNMTi","g8","L6600-02","in 10mM DMSO","NNMT","Methylation","NNMTi (Compound 1k, NNMT inhibitor) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.2 μM.",286.11,"42464-96-0",{"v":57,"d":"57.00"},199.22,{"v":5,"d":"5.00"},17.48,"http://www.selleckchem.com/products/nnmti.html","C10H11N2.I","Free Base","Compound 1k, NNMT inhibitor","[I-].C[N+]1=CC=CC2=C(N)C=CC=C12",{"v":-1.23,"d":"-1.230"},0,1,0]
["S3543","DC-05","h8","L6600-02","in 10mM DMSO","DNA Methyltransferase","Epigenetics","DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively.",383.49,"890643-16-0",{"v":77,"d":"77.00"},200.79,"<1","N/A","http://www.selleckchem.com/products/dc-05.html","C25H25N3O","free base","N/A","OC(CNCCC1=C[NH]C2=CC=CC=C12)C[N]3C4=CC=CC=C4C5=CC=CC=C35",4.819,0,3,7]
["E1059","UNC6934","a9","L6600-02","in 10mM DMSO","NSD","Methylation","UNC6934 is a a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. UNC6934 is a potent antagonist of NSD2-PWWP1 with a Kd (SPR) of 80 nM and is selective for NSD2-PWWP1 over 14 other PWWP domains including NSD3-PWWP1 UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells as measured by a NanoBret assay with an IC50 of 1.09 μM.",443.46,"2561494-77-5",{"v":22,"d":"22.00"},49.61,"<1","N/A","http://www.selleckchem.com/products/unc6934.html","C24H21N5O4","free base","N/A","O=C1COC2=C(N1)C=CC(=C2)C(=O)N(CC3=CC=C(C=C3)C(=O)NC4=CC=NC=N4)C5CC5",1.652,6,2,6]
["S7062","Pinometostat (EPZ5676)","b9","L6600-02","in 10mM DMSO","DOT1,Histone Methyltransferase","Epigenetics","Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1.",562.71,"1380288-87-8",{"v":100,"d":"100.00"},177.71,"<1","N/A","http://www.selleckchem.com/products/epz-5676.html","C30H42N8O3","free base","N/A","CC(C)N(CC1OC(C(O)C1O)[N]2C=NC3=C2N=CN=C3N)C4CC(CCC5=NC6=CC=C(C=C6[NH]5)C(C)(C)C)C4",3.567,5,4,9]
["S7817","MI-503","c9","L6600-02","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines(GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations.",564.63,"1857417-13-0",{"v":100,"d":"100.00"},177.11,"<1","N/A","http://www.selleckchem.com/products/mi-503.html","C28H27F3N8S","free base","N/A","CC1=C2C=C(C#N)[N](CC3=C[NH]N=C3)C2=CC=C1CN4CCC(CC4)NC5=C6C=C(CC(F)(F)F)SC6=NC=N5",5.606,3,2,8]
["S8344","AZD-5153 6-hydroxy-2-naphthoic acid","d9","L6600-02","in 10mM DMSO","Epigenetic Reader Domain,NSD","Epigenetics","AZD-5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD-5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.",667.75,"1869912-40-2",{"v":100,"d":"100.00"},149.76,"<1","N/A","http://www.selleckchem.com/products/azd5153-6-hydroxy-2-naphthoic-acid.html","C25H33N7O3.C11H8O3","free base","AZD-5153 HNT salt","COC1=NN=C2C=CC(=N[N]12)N3CCC(CC3)C4=CC=C(OCCN5CCN(C)C(=O)C5C)C=C4.OC(=O)C6=CC=C7C=C(O)C=CC7=C6",2.347,7,1,8]
["S8983","MAK683","e9","L6600-02","in 10mM DMSO","Histone Methyltransferase","Epigenetics","MAK683 (EED inhibitor-1, example 2) is an inhibitor of embryonic ectoderm development (EED). MAK683 exhibits IC50 of 59 nM, 89 nM and 26 nM in EED Alphascreen binding, LC-MS and ELISA assay, respectively.",376.39,"1951408-58-4",{"v":20,"d":"20.00"},53.14,"<1","N/A","http://www.selleckchem.com/products/mak683.html","C20H17FN6O","free base","EED inhibitor-1","CC1=C(C=CC=N1)C2=CN=C(NCC3=C(F)C=CC4=C3CCO4)[N]5C=NN=C25",2.824,5,1,4]
["S9659","UNC6852","f9","L6600-02","in 10mM DMSO","Epigenetic Reader Domain,Histone Methyltransferase,PROTAC","Epigenetics","UNC6852 is a selective degrader that targets polycomb repressive complex 2 (PRC2) with IC50 of 247 nM for EED. UNC6852 is based on PROTAC and contains an EED226-derived ligand and a ligand for VHL.",832.97,"2688842-08-0",{"v":100,"d":"100.00"},120.05,"<1","N/A","http://www.selleckchem.com/products/unc6852.html","C43H48N10O6S","free base","N/A","CC1=C(SC=N1)C2=CC=C(CNC(=O)C3CC(O)CN3C(=O)C(NC(=O)CCCNC(=O)C4=CC=C(C=C4)C5=CN=C(NCC6=CC=CO6)[N]7C=NN=C57)C(C)(C)C)C=C2",3.011,9,5,16]
["S0269","GSK467","g9","L6600-02","in 10mM DMSO","Histone Demethylase","Epigenetics","GSK467 is a cell penetrant and selective inhibitor of KDM5B (JARID1B/PLU1) with Ki of 10 nM. GSK467 shows apparent 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other JmJ family members.",319.32,"1628332-52-4",{"v":8,"d":"8.00"},25.05,"<1","N/A","http://www.selleckchem.com/products/gsk467.html","C17H13N5O2","Free base","N/A","O=C1N=C(NC2=C1C=CN=C2)OC3=C[N](CC4=CC=CC=C4)N=C3",2.131,5,1,4]
["S0356","Pulrodemstat (CC-90011) besylate","h9","L6600-02","in 10mM DMSO","Histone Demethylase,LSD1","Methylation","Pulrodemstat (CC-90011) besylate (LSD1-IN-7 benzenesulfonate) is a potent and orally active lysine specific demethylase-1 (LSD1) inhibitor that is found to be effective in various tumors.",609.64,"2097523-60-7",{"v":100,"d":"100.00"},164.03,"<1","N/A","http://www.selleckchem.com/products/cc-90011.html","C30H29F2N5O5S","Besylate","LSD1-IN-7 benzenesulfonate","COC1=C(F)C=C(C=C1)C2=C(N=C(N(C)C2=O)N3CCC(N)CC3)C4=CC(=C(C=C4)C#N)F.O[S](=O)(=O)C5=CC=CC=C5",3.467,3,1,5]
["S2943","BRD9539","a10","L6600-02","in 10mM DMSO","Epigenetic Reader Domain,G9a/GLP","Epigenetics","BRD9539 is a histone methyltransferase G9a inhibitor, which also inhibits PRC2 activity.",399.44,"1374601-41-8",{"v":80,"d":"80.00"},200.28,"<1","N/A","http://www.selleckchem.com/products/brd9539.html","C24H21N3O3","Free bC22H16Cl3N7O6ase","N/A","OC(=O)C1=CC=C2[N](CCCC3=CC=CC=C3)C(=NC2=C1)NC(=O)C4=CC=CC=C4",4.868,3,1,7]
["S6984","Dianhydrogalactitol (VAL-083)","b10","L6600-02","in 10mM DMSO","DNA alkylator","DNA Damage/DNA Repair","Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.",146.14,"23261-20-3",{"v":29,"d":"29.00"},198.44,{"v":29,"d":"29.00"},198.44,"http://www.selleckchem.com/products/dianhydrogalactitol-val-083.html","C6H10O4","Free base","Dianhydrodulcitol, Dulcitol Diepoxide","OC(C(O)C1CO1)C2CO2",-1.408,2,2,3]
["S7013","Guadecitabine (SGI-110)","c10","L6600-02","in 10mM DMSO","Others","Methylation","Guadecitabine (SGI-110, S-110) is a next-generation hypomethylating agent.",579.39,"929904-85-8",{"v":100,"d":"100.00"},{"v":172.6,"d":"172.60"},{"v":50,"d":"50.00"},{"v":86.3,"d":"86.30"},"http://www.selleckchem.com/products/sgi-110.html","C18 H23 N9 O10 P . Na","Free base","S-110","NC1=NC2=C(N=C[N]2C3CC(O)C(CO[P](=O)(O[Na])OC4CC(OC4CO)N5C=NC(=NC5=O)N)O3)C(=O)N1",-2.289,11,5,9]
["S7042","AZ505","d10","L6600-02","in 10mM DMSO","SMYD","Epigenetics","AZ505 is a potent and selective inhibitor of SMYD2 with an IC50 of 0.12 μM.",577.54,"1035227-43-0",{"v":100,"d":"100.00"},173.15,"<1","N/A","http://www.selleckchem.com/products/az505.html","C29H38Cl2N4O4","Free base","N/A","OC1=C2NC(=O)COC2=C(CCNCCN(C3CCCCC3)C(=O)CCNCCC4=CC(=C(Cl)C=C4)Cl)C=C1",4.445,3,4,13]
["S8858","GSK3368715 (EPZ019997) 3HCl","e10","L6600-02","in 10mM DMSO","PRMT","Methylation","GSK3368715 is a potent inhibitor of type I protein arginine methyltransferases (PRMT) that inhibits PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM.",475.92,"2227587-26-8",{"v":81,"d":"81.00"},{"v":170.2,"d":"170.20"},{"v":81,"d":"81.00"},{"v":170.2,"d":"170.20"},"http://www.selleckchem.com/products/gsk3368715.html","C20H41Cl3N4O2","Trihydrochloride","N/A","Cl.Cl.Cl.CCOCC1(CCC(CC1)C2=N[NH]C=C2CN(C)CCNC)COCC",3.296,3,2,12]
["S8926","Valemetostat (DS-3201)","f10","L6600-02","in 10mM DMSO","EZH1/2","Methylation","Valemetostat (DS-3201, DS-3201b) is a selective EZH1/2 dual inhibitor.",488.02,"1809336-39-7",{"v":100,"d":"100.00"},204.91,"<1","N/A","http://www.selleckchem.com/products/valemetostat-ds-3201.html","C26H34ClN3O4","Free base","DS-3201b","CN(C)C1CCC(CC1)C2(C)OC3=C(Cl)C=C(C(=O)NCC4=C(C)C=C(C)NC4=O)C(=C3O2)C",3.963,4,2,5]
["S8934","VTP50469","g10","L6600-02","in 10mM DMSO","Histone Methyltransferase,MLL","Epigenetics","VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with Ki of 104 pM. VTP50469 exhibits anti-leukemia activity.",630.82,"2169916-18-9",{"v":100,"d":"100.00"},158.52,"<1","N/A","http://www.selleckchem.com/products/vtp50469.html","C32H47FN6O4S","Free base","N/A","CC(C)N(C(C)C)C(=O)C1=C(OC2=CN=CN=C2N3CC4(CCN(CC4)CC5CCC(CC5)N[S](C)(=O)=O)C3)C=CC(=C1)F",4.089,6,1,10]
["E0132","NCGC00244536","h10","L6600-02","in 10mM DMSO","Histone Demethylase","Epigenetics","NCGC00244536 is a novel KDM4 Inhibitor with an IC50 of ∼10 nM.",382.45,"2003260-55-5",{"v":76,"d":"76.00"},198.72,"<1","N/A","http://www.selleckchem.com/products/ncgc00244536.html","C25H22N2O2","Free base","N/A","OC1=C2N=CC=CC2=CC(=C1)C3=CC(=CC=C3)C(=O)NCCCC4=CC=CC=C4",4.861,2,2,6]
["E1007","BRD0639","a11","L6600-02","in 10mM DMSO","PRMT","Epigenetics","BRD0639 is a first-in-class PBM-competitive small molecule inhibitor that disrupts the PRMT5-RIOK1 complex  with IC50s of 7.5 μM and 16 μM in permeabilized and living cells, respectively.",475.95,"2760881-74-9",{"v":95,"d":"95.00"},{"v":199.6,"d":"199.60"},"<1","N/A","http://www.selleckchem.com/products/brd0639.html","C21H22ClN5O4S","Free base","N/A","CC(N1N=CC(=CC1=O)Cl)C(=O)NC2=CC=C(C)C(=C2)[S](=O)(=O)NCCC3=NC=CC=C3",1.683,6,2,8]
["E1088","TP-064","b11","L6600-02","in 10mM DMSO","PRMT","Methylation","TP-064 is a potent and selective small molecule inhibitor of PRMT4 with IC50 < 10 nM, >100 fold more selective for PRMT4 than other PRMTs.",{"v":458.6,"d":"458.60"},"2080306-20-1",{"v":92,"d":"92.00"},200.61,{"v":92,"d":"92.00"},200.61,"http://www.selleckchem.com/products/tp-064.html","C28H34N4O2","Free base","N/A","CNCCN1CCC(CC1)C2=NC=CC(=C2)CN(C)C(=O)C3=CC(=CC=C3)OC4=CC=CC=C4",3.749,3,1,9]
["E1167","X1 compound","c11","L6600-02","in 10mM DMSO","Others","Others","X1 compound binding reduces the conformational space of RepA, displaces cognate interacting protein factors (PRC2 and SPEN), suppresses histone H3K27 trimethylation, and blocks initiation of X-chromosome inactivation.",416.48,"2863686-82-0",{"v":83,"d":"83.00"},199.29,"<1","N/A","http://www.selleckchem.com/products/x1-compound.html","C27H20N4O","Free base","N/A","C(OC1=CC(=CC=C1)C2=CC=C3[NH]N=C(C4=NC5=C([NH]4)C=CC=C5)C3=C2)C6=CC=CC=C6",6.428,3,2,5]
["E1179","EZM0414","d11","L6600-02","in 10mM DMSO","SETD","Methylation","EZM0414 is a potent, selective, and orally bioavailable inhibitor of Histone-lysine N-methyltransferase SETD2.",400.49,"2411748-50-8",{"v":40,"d":"40.00"},99.88,"<1","N/A","http://www.selleckchem.com/products/ezm0414.html","C22H29FN4O2","Free base","N/A","CC(=O)N1CCN(CC1)C2CCCC(C2)NC(=O)C3=CC4=C(F)C=CC(=C4[NH]3)C",2.707,2,2,3]
["S4811","VitaMin U","a2","L6600-03","in 10mM Water","Vitamin","Metabolism","Vitamin U (Methylmethioninesulfonium Chloride, Cabagin-U, Smethylmethionine) is a vitamin found in green vegetables. It is used in the treatment of peptic ulcers, colitis, and gastritis and has an effect on secretory, acid-forming, and enzymatic functions of the intestinal tract.",{"v":199.7,"d":"199.70"},"3493-12-7","<1","N/A",{"v":39,"d":"39.00"},195.29,"http://selleckchem.com/products/vitamin-u.html","C6H14NO2.Cl","chloride","Methylmethioninesulfonium Chloride, Cabagin-U, Smethylmethionine","[Cl-].C[S+](C)CCC(N)C(O)=O",{"v":0,"d":"0.000"},0,0,0]
["S5545","DL-Serine","b2","L6600-03","in 10mM Water","PKM","Metabolism","Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.",105.09,"302-84-1","<1","N/A",{"v":8,"d":"8.00"},76.13,"http://selleckchem.com/products/dl-serine.html","C3H7NO3","salt","N/A","NC(CO)C(O)=O",-4.049,1,2,2]
["S7873","Disodium (R)-2-Hydroxyglutarate","c2","L6600-03","in 10mM Water","ROS","Immunology & Inflammation","Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 10.87 ± 1.85 mM.",192.08,"103404-90-6","<1","N/A",{"v":38,"d":"38.00"},197.83,"http://selleckchem.com/products/disodium-r-2-hydroxyglutarate.html","C5H6Na2O5","disodium salt","D-α-Hydroxyglutaric acid disodium","OC(CCC(=O)O[Na])C(=O)O[Na]",-0.509,4,1,6]
["S1325","L-2-Hydroxyglutaric acid disodium","d2","L6600-03","in 10mM Water","Histone Demethylase","Epigenetics","L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.",192.08,"63512-50-5","<1","N/A",{"v":38,"d":"38.00"},197.83,"https://www.selleckchem.com/products/l-2-hydroxyglutaric-acid-disodium.html","C5H6Na2O5","Disodium","(S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG","[Na+].[Na+].OC(CCC([O-])=O)C([O-])=O",-3.639,0,1,4]
["E0351","NSC232003","e2","L6600-03","in 10mM Water","E3 Ligase","Ubiquitin","NSC232003 is a highly potent and cell-permeable UHRF1 inhibitor that binds to the 5mC binding pocket of the SRA domain of UHRF1. NSC232003 modulates DNA methylation in a cellular context.",169.14,"1905453-18-0","<1","N/A",{"v":5,"d":"5.00"},29.56,"http://www.selleckchem.com/products/nsc232003.html","C6H7N3O3","Free Base","N/A","CC(NO)=C1C=NC(=O)NC1=O",{"v":-0.7,"d":"-0.700"},3,2,1]
["S4605","Folic acid","a2","L6600-04","in 2mM DMSO","Vitamin","Metabolism","Folic acid (Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate), a B vitamin, plays an important role in cell division and in the synthesis of amino acids and nucleic acids like DNA.",{"v":441.4,"d":"441.40"},"59-30-3",{"v":2,"d":"2.00"},4.53,"<1","N/A","http://selleckchem.com/products/folic-acid.html","C19H19N7O6","free base","Folacin, Vitamin B9, Vitamin M, Pteroylglutamic acid, Folate","NC1=NC(=O)C2=C(N1)N=CC(=N2)CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O",-0.232,7,4,9]
["S7004","EPZ005687","b2","L6600-04","in 2mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM in a cell-free assay, 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases.",539.67,"1396772-26-1",{"v":2,"d":"2.00"},3.71,"<1","N/A","http://selleckchem.com/products/epz005687.html","C32H37N5O3","Free Base","N/A","CC1=CC(=C(CNC(=O)C2=CC(=CC3=C2C=N[N]3C4CCCC4)C5=CC=C(CN6CCOCC6)C=C5)C(=O)N1)C",3.919,4,2,7]
["S7061","GSK126","c2","L6600-04","in 2mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","GSK126 (GSK2816126A, GSK2816126) is a potent, highly selective EZH2 methyltransferase inhibitor with IC50 of 9.9 nM, >1000-fold selective for EZH2 over 20 other human methyltransferases.",526.67,"1346574-57-9",{"v":3,"d":"3.00"},{"v":5.7,"d":"5.70"},"<1","N/A","http://selleckchem.com/products/gsk126.html","C31H38N6O2","Free Base","GSK2816126A, GSK2816126","CCC(C)[N]1C=C(C)C2=C(C=C(C=C12)C3=CC=C(N=C3)N4CCNCC4)C(=O)NCC5=C(C)C=C(C)NC5=O",4.114,3,3,7]
["S7128","Tazemetostat (EPZ-6438)","d2","L6600-04","in 2mM DMSO","EZH1/2,Histone Methyltransferase","Epigenetics","Tazemetostat (EPZ-6438, E7438) is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.",572.74,"1403254-99-8",{"v":5,"d":"5.00"},8.73,"<1","N/A","http://selleckchem.com/products/epz-6438.html","C34H44N4O4","free base","E7438","CCN(C1CCOCC1)C2=C(C)C(=CC(=C2)C3=CC=C(CN4CCOCC4)C=C3)C(=O)NCC5=C(C)C=C(C)NC5=O",3.506,4,2,9]
["S7164","GSK343","e2","L6600-04","in 2mM DMSO","Autophagy,EZH1/2,Histone Methyltransferase","Epigenetics","GSK343 is a potent and selective EZH2 inhibitor with IC50 of 4 nM in a cell-free assay, showing 60 fold selectivity against EZH1, and >1000 fold selectivity against other histone methyltransferases. GSK343 induces autophagy.",541.69,"1346704-33-3",{"v":2,"d":"2.00"},3.69,"<1","N/A","http://www.selleck.cn/products/gsk343.html","C31H39N7O2","Free Base","N/A","CCCC1=C(CNC(=O)C2=CC(=CC3=C2C=N[N]3C(C)C)C4=CC(=NC=C4)N5CCN(C)CC5)C(=O)NC(=C1)C",3.902,4,2,8]
["S9872","AG-270","f2","L6600-04","in 2mM DMSO","MAT2A","Methylation","AG-270 is a potent and non-competitive methionine adenosyltransferase 2A (MAT2A) inhibitor which lessens the intracellular SAM levels  and MTAP-null–selective antiproliferative activity.",489.57,"2201056-66-6",{"v":3,"d":"3.00"},6.13,"<1","N/A","https://www.selleckchem.com/products/ag-270.html","C30H27N5O2","Free base","N/A","COC1=CC=C(C=C1)C2=C(NC3=CC=CC=N3)NC4=C(C5=CCCCC5)C(=N[N]4C2=O)C6=CC=CC=C6",6.837,4,2,6]