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[{"$nulls":3},"Calcium Channel Blocker Library  (96-well)-L9000"]
[null,"For more information on Selleck library service, please contact us via +1-832-582-8158 or library@selleckchem.com"]
[]
[null,"Product Details:"]
[null,"Description",null,"A unique collection of 170 compounds"]
[null,"Container",null,"96 Well"]
[null,"Stability",null,"12 months | ﹣20°C | in DMSO"]
[{"$nulls":3},"24 months | ﹣80°C | in DMSO"]
[null,"Shipping",null,"Blue ice or Dry ice"]
[null,"Formulation",null,"Solubility ≥10 mM pre-dissolved in 10 mM solution and solubility between 2 mM and 10 mM pre-dissolved in 2 mM solution"]
[{"$nulls":3},"In 10 mM DMSO : Plate layout L9000-01~02;    In 2 mM DMSO : Plate layout L9000-04"]
[{"$nulls":3},"In 10 mM Water: Plate layout L9000-03;      In 2 mM Water  : Plate layout L9000-05"]
[]
[]
[]
[null,"Plate layout: L9000-01"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1293","S1747","S1885","S2403","S2721","S3674","S4057","S4353","S4727","S5255","Empty"]
[{"$nulls":3},"Cilnidipine (FRC-8653)","Nimodipine","Felodipine","Tetrandrine (NSC-77037)","Nilvadipine","Levamlodipine","Methyclothiazide","Terfenadine","Cinnarizine","Nicardipine"]
[null,"b","Empty","S1330","S1748","S1905","S2415","S2857","S3682","S4084","S4505","S4902","S5279","Empty"]
[{"$nulls":3},"Felbamate","Nisoldipine","Amlodipine","Astragaloside A","(-)-Dizocilpine (MK 801) Maleate","Ethyl 3-Aminobenzoate methanesulfonate","Lomerizine 2HCl","Vinblastine (NSC-49842) sulfate","QNZ (EVP4593)","Fendiline hydrochloride"]
[null,"c","Empty","S1356","S1799","S1994","S2446","S2860","S3700","S4091","S4597","S4931","S5478","Empty"]
[{"$nulls":3},"Levetiracetam (UCB-L059)","Ranolazine","Lacidipine","Levosimendan","IEM 1754 2HBr","DHBP dibromide","Ifenprodil Tartrate","Lercanidipine hydrochloride","Propiverine hydrochloride","Dantrolene sodium"]
[null,"d","Empty","S1425","S1805","S2017","S2481","S2876","S3766","S4151","S4626","S4957","S5514","Empty"]
[{"$nulls":3},"Ranolazine 2HCl","Acetylcholine Chloride","Benidipine HCl","Manidipine","(+)-Dizocilpine (MK 801) Maleate","Tanshinone IIA sulfonate sodium","Penfluridol","Ethosuximide","Linalool","Lanthanum(III) chloride heptahydrate"]
[null,"e","Empty","S1438","S1808","S2030","S2482","S3018","S3809","S4162","S4648","S4977","S5561","Empty"]
[{"$nulls":3},"Topiramate","Nifedipine (BAY-a-1040)","Flunarizine 2HCl","Manidipine 2HCl","Niflumic acid","Imperatorin","Benzethonium Chloride","Dantrolene sodium hemiheptahydrate","Efonidipine","Ethacrynic Acid"]
[null,"f","Empty","S1445","S1811","S2080","S2491","S3045","S3883","S4181","S4714","S5032","S5567","Empty"]
[{"$nulls":3},"Zonisamide","Amiloride (MK-870) HCl","Clevidipine Butyrate","Nitrendipine","Cinepazide maleate","Protopine","Nicardipine HCl","(-)-Menthol","Mephenesin","Trimethadione"]
[null,"g","Empty","S1573","S1813","S2114","S2535","S3053","S3931","S4202","S4716","S5042","S5664","Empty"]
[{"$nulls":3},"Fasudil (HA-1077) HCl","Amlodipine Besylate","Dronedarone HCl","Econazole nitrate","Azelnidipine","Ginsenoside Rd","Verapamil (CP-16533-1) HCl","Evans Blue","Bevantolol hydrochloride","Orphenadrine Hydrochloride"]
[null,"h","Empty","S1662","S1865","S2118","S2573","S3653","S3933","S4268","S4719","S5164","S5787","Empty"]
[{"$nulls":3},"Isradipine","Diltiazem HCl","Ibutilide Fumarate","Tetracaine HCl","Spermidine trihydrochloride","10-deacetyl-paclitaxel","Flufenamic acid","Kynurenic acid","Chlorotetracycline","Dronedarone"]
[]
[]
[]
[null,"Plate layout: L9000-02"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S5861","S8388","S9409","S6634","S0405","S6906","S6934","E0026","E0777","S8513","Empty"]
[{"$nulls":3},"Lercanidipine","ML-7 HCl","Kavain","SAR7334","AF-353","Capric acid","AMG-9810","ML-SI3","Z944","JNJ-47965567"]
[null,"b","Empty","S6410","S8691","S9459","S6657","S0758","S0000","S9686","S0452","E0826","E0357","Empty"]
[{"$nulls":3},"Clemizole","ML204","Mecamylamine Hydrochloride","2-Aminoethyl Diphenylborinate (2-APB)","BX430","Cav 2.2 blocker 1","NBQX (FG9202)","NP118809","Levamlodipine Besylate","Eliapixant"]
[null,"c","Empty","S6473","S9100","S9487","S6676","S0973","S0552","S5898","S0518","E1050","E1259","Empty"]
[{"$nulls":3},"Pinaverium bromide","Fraxinellone","Praeruptorin C","Ebselen","Wilforgine","BNC210","Efonidipine hydrochloride monoethanolate","NS 1738","PEAQX","DNQX"]
[null,"d","Empty","S7392","S9141","S9566","S2650","S3217","S0750","S5966","S0521","E2684","E1368","Empty"]
[{"$nulls":3},"Loxistatin Acid (E-64C)","Berbamine","Bepridil hydrochloride","RN-1734","Brilliant Blue G","GFB-8438","Amlodipine maleate","PNU-282987 S enantiomer free base","Icilin","PD173212"]
[null,"e","Empty","S7924","S9151","S6637","S6815","S3236","S0826","S0446","S2957","S0702","E1410","Empty"]
[{"$nulls":3},"Bay K 8644","Praeruptorin E","HC-067047","CDN1163","Mesaconitine","A-740003","TCN 201","Encenicline (EVP-6124) hydrochloride","α-Conotoxin GI","Fluspirilene"]
[null,"f","Empty","S7999","S9179","S6638","S6838","S3242","S0870","E0028","S3535","S2975","E2984","Empty"]
[{"$nulls":3},"SKF96365","Catharanthine hemitartrate","AMG-333","BCTC","Loureirin B","Barnidipine","9-Phenanthrol","Deudextromethorphan (AVP-786)","CarboxyaMidotriazole orotate","GSK-7975A"]
[null,"g","Empty","S8208","S9315","S6644","S0016","S6664","S0977","S6070","E0379","S3520","E2993","Empty"]
[{"$nulls":3},"Hydroxyfasudil (HA-1100) HCl","Praeruptorin A","Radiprodil (RGH-896)","SN-6","Gefapixant","AC1903","CBA (TRPM4-IN-5)","SEN12333","AZ10606120 dihydrochloride","Ruthenium Red"]
[null,"h","Empty","S8380","S9400","S2436","S0174","S6847","S2953","S9498","E0484","S6731","Empty","Empty"]
[{"$nulls":3},"YM-58483 (BTP2)","Rhynchophylline","Pranidipine","TRPM8 antagonist 2","ML-9 HCl","Dooku1","5-BDBD","CNQX","Eliprodil (SL-820715)"]
[]
[]
[]
[null,"Plate layout: L9000-03"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1338","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Gabapentin HCl"]
[null,"b","Empty","S2133","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Gabapentin"]
[null,"c","Empty","S2568","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Neomycin sulfate"]
[null,"d","Empty","S5022","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Varenicline Hydrochloride"]
[null,"e","Empty","E1246","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"D-AP5"]
[null,"f","Empty","E2979","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"DL-AP5 (2-APV)"]
[null,"g","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[]
[]
[]
[null,"Plate layout: L9000-04"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S2251","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"(-)-Huperzine A (HupA)"]
[null,"b","Empty","S4156","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Chlortetracycline HCl (NSC 13252)"]
[null,"c","Empty","S6632","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Mirogabalin (DS-5565)"]
[null,"d","Empty","E0524","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Spinosad"]
[null,"e","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"f","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"g","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[]
[]
[]
[null,"Plate layout: L9000-05"]
[null,null,1,2,3,4,5,6,7,8,9,10,11,12]
[null,"a","Empty","S1911","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[{"$nulls":3},"Disodium Cromoglycate"]
[null,"b","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"c","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"d","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"e","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"f","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"g","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]
[]
[null,"h","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty","Empty"]

{"sheet":"L9000-Calcium-Channel-170 cpds","index":1,"n_rows":171,"n_cols":23,"rows_kept":171}
["Cat","Name","Plate Location","Rack Number","Formulation","Target","Pathway","Information","M.w.","CAS Number","DMSO (mg/mL)Max Solubility","DMSO (mM)Max Solubility","Water (mg/mL)Max Solubility","Water (mM)Max Solubility","URL","Formula","Form","Synonyms","SMILES","ALogP","HBA_Count","HBD_Count","RotatableBond"]
["S1293","Cilnidipine (FRC-8653)","a2","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Cilnidipine (FRC-8653) is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.",492.52,"132203-70-4",{"v":99,"d":"99.00"},201.01,"<1","N/A","http://selleckchem.com/products/Cilnidipine.html","C27H28N2O7","free base","FRC-8653","COCCOC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC\\C=C\\C3=CC=CC=C3)C",3.686,5,1,12]
["S1330","Felbamate","b2","L9000-01","in 10mM DMSO","NMDAR","Neuronal Signaling","Felbamate (Felbatol, ADD-03055,W-554) is an anticonvulsant drug used in the treatment of epilepsy; NMDAR antagonist.",238.24,"25451-15-4",{"v":48,"d":"48.00"},201.48,"<1","N/A","http://selleckchem.com/products/Felbamate.html","C11H14N2O4","free base","Felbatol, ADD-03055,W-554","NC(=O)OCC(COC(N)=O)C1=CC=CC=C1",0.984,4,2,7]
["S1356","Levetiracetam (UCB-L059)","c2","L9000-01","in 10mM DMSO","AChR,Calcium Channel","Transmembrane Transporters","Levetiracetam (UCB-L059, SIB-S1) is an anticonvulsant medication used to treat epilepsy. Levetiracetam (UCB-L059, SIB-S1) is an agonist of muscarinic acetylcholine receptors (mAChR). Levetiracetam modulates the presynaptic P/Q-type voltage-dependent calcium (Ca2+) channel.",170.21,"102767-28-2",{"v":34,"d":"34.00"},199.75,{"v":34,"d":"34.00"},199.75,"http://selleckchem.com/products/Levetiracetam.html","C8H14N2O2","free base","UCB-L059, SIB-S1","CCC(N1CCCC1=O)C(N)=O",-0.304,2,1,3]
["S1425","Ranolazine 2HCl","d2","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ranolazine 2HCl (RS-43285,RS 43285-193,Ranexa, renolazine,Ranolazine dihydrochloride) is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.",500.46,"95635-56-6",{"v":100,"d":"100.00"},199.82,{"v":100,"d":"100.00"},199.82,"http://selleckchem.com/products/Ranolazine-dihydrochloride.html","C24H33N3O4.2HCl","Dihydrochloride","RS-43285,RS 43285-193,Ranexa, renolazine,Ranolazine dihydrochloride","Cl.Cl.COC1=CC=CC=C1OCC(O)CN2CCN(CC2)CC(=O)NC3=C(C)C=CC=C3C",3.755,3,2,9]
["S1438","Topiramate","e2","L9000-01","in 10mM DMSO","Carbonic Anhydrase","Metabolism","Topiramate (MCN 4853, RWJ 17021) is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.",339.36,"97240-79-4",{"v":68,"d":"68.00"},200.38,"<1","N/A","http://selleckchem.com/products/Topiramate.html","C12H21NO8S","free base","MCN 4853, RWJ 17021","CC1(C)OC2COC3(CO[S](N)(=O)=O)OC(C)(C)OC3C2O1",-1.932,6,1,3]
["S1445","Zonisamide","f2","L9000-01","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Zonisamide (Zonegran,CI-912,AD 810) is a voltage-dependent sodium channel and T-type calcium channel blocker, used as an antiepileptic drug.",212.23,"68291-97-4",{"v":42,"d":"42.00"},{"v":197.9,"d":"197.90"},"<1","N/A","http://selleckchem.com/products/Zonisamide.html","C8H8N2O3S","free base","Zonegran,CI-912,AD 810","N[S](=O)(=O)CC1=NOC2=CC=CC=C12",0.411,4,1,2]
["S1573","Fasudil (HA-1077) HCl","g2","L9000-01","in 10mM DMSO","Autophagy,Calcium Channel,MLCK,PKA,PKC,PKG,Rho,ROCK","Cell Cycle","Fasudil (HA-1077, AT-877), a potent and selective inhibitor of Rho kinase, displays less potent inhibiton over PKA, PKG, PKC and MLCK with Ki of 1.6, 1.6, 3.3, and 36 μM in cell-free assays, respectively. Fasudil is also a calcium channel blocker.",327.83,"105628-07-7",{"v":5,"d":"5.00"},15.25,{"v":65,"d":"65.00"},198.27,"http://selleckchem.com/products/Fasudil-HCl(HA-1077).html","C14H17N3O2S.HCl","Hydrochloride","AT-877,HA-1077 HCl","Cl.O=[S](=O)(N1CCCNCC1)C2=C3C=CN=CC3=CC=C2",{"v":0.57,"d":"0.570"},3,1,2]
["S1662","Isradipine","h2","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Isradipine (PN 200-110) is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.",371.39,"75695-93-1",{"v":74,"d":"74.00"},199.25,"<1","N/A","http://selleckchem.com/products/Isradipine(Dynacirc).html","C19H21N3O5","free base","PN 200-110","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC3=NON=C23)C(=O)OC(C)C)C",2.168,7,1,6]
["S1747","Nimodipine","a3","L9000-01","in 10mM DMSO","Autophagy,Calcium Channel","Transmembrane Transporters","Nimodipine (BAY E 9736) is a dihydropyridine calcium channel blocker and an autophagy inhibitor, used in the treatment of high blood pressure.",418.44,"66085-59-4",{"v":84,"d":"84.00"},200.75,"<1","N/A","http://selleckchem.com/products/Nimodipine(Nimotop).html","C21H26N2O7","free base","BAY E 9736","COCCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)C)C",2.361,5,1,10]
["S1748","Nisoldipine","b3","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nisoldipine (Sular, BAY K 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.",388.41,"63675-72-9",{"v":77,"d":"77.00"},198.24,"<1","N/A","http://selleckchem.com/products/Nisoldipine(Sular).html","C20H24N2O6","free base","BAY K 5552","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC=C2[N+]([O-])=O)C(=O)OCC(C)C)C",2.958,4,1,8]
["S1799","Ranolazine","c3","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ranolazine (CVT 303, RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina.",427.54,"95635-55-5",{"v":86,"d":"86.00"},201.15,"<1","N/A","http://selleckchem.com/products/Ranolazine(Ranexa).html","C24H33N3O4","Free Base","CVT 303, RS 43285-003","COC1=CC=CC=C1OCC(O)CN2CCN(CC2)CC(=O)NC3=C(C)C=CC=C3C",2.991,3,2,9]
["S1805","Acetylcholine Chloride","d3","L9000-01","in 10mM DMSO","AChR","Neuronal Signaling","The chemical compound Acetylcholine Chloride(ACh chloride) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans.",181.66,"60-31-1",{"v":36,"d":"36.00"},198.17,{"v":36,"d":"36.00"},198.17,"http://www.selleck.cn/products/Acetylcholine-chloride.html","C7H16NO2.Cl","Chloride","ACh chloride","[Cl-].CC(=O)OCC[N+](C)(C)C",-3.869,2,0,4]
["S1808","Nifedipine (BAY-a-1040)","e3","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nifedipine (BAY-a-1040) is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.",346.33,"21829-25-4",{"v":69,"d":"69.00"},199.23,"<1","N/A","http://selleckchem.com/products/Nifedipine(Adalat).html","C17H18N2O6","free base","BAY-a-1040","COC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)[N+]([O-])=O)C(=O)OC)C",1.766,4,1,6]
["S1811","Amiloride (MK-870) HCl","f3","L9000-01","in 10mM DMSO","Calcium Channel,Serine Protease,Sodium Channel","Transmembrane Transporters","Amiloride (MK-870 HCl) is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).",266.09,"2016-88-8",{"v":53,"d":"53.00"},199.18,{"v":6,"d":"6.00"},22.55,"http://selleckchem.com/products/Amiloride-hydrochloride(Midamor).html","C6H8ClN7O.HCl","Hydrochloride","MK-870 HCl","Cl.NC(=N)NC(=O)C1=NC(=C(N)N=C1N)Cl",-0.366,3,4,2]
["S1813","Amlodipine Besylate","g3","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Amlodipine Besylate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.",567.05,"111470-99-6",{"v":113,"d":"113.00"},199.28,"<1","N/A","http://selleckchem.com/products/Amlodipine-besylate(Norvasc).html","C20H25ClN2O5.C6H6O3S","Besylate","N/A","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=C(Cl)C=CC=C2)C(=O)OC)C.O[S](=O)(=O)C3=CC=CC=C3",2.739,5,2,11]
["S1865","Diltiazem HCl","h3","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Diltiazem (Tiazac, RG 83606) HCl is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.",450.98,"33286-22-5",{"v":90,"d":"90.00"},199.57,{"v":90,"d":"90.00"},199.57,"http://selleckchem.com/products/Diltiazem-HCl(Tiazac).html","C22H26N2O4S.HCl","Hydrochloride","RG 83606 HCl","Cl.COC1=CC=C(C=C1)C2SC3=C(C=CC=C3)N(CCN(C)C)C(=O)C2OC(C)=O",3.475,4,0,7]
["S1885","Felodipine","a4","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Felodipine (CGH-869) is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM.",384.25,"72509-76-3",{"v":77,"d":"77.00"},200.39,"<1","N/A","http://selleckchem.com/products/Felodipine(Plendil).html","C18H19Cl2NO4","free base","CGH-869","CCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2Cl)Cl)C(=O)OC)C",3.549,4,1,6]
["S1905","Amlodipine","b4","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.",408.88,"88150-42-9",{"v":82,"d":"82.00"},200.55,"<1","N/A","http://selleckchem.com/products/Amlodipine(Norvasc).html","C20H25ClN2O5","free base","UK-48340","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=C(Cl)C=CC=C2)C(=O)OC)C",1.576,5,2,10]
["S1994","Lacidipine","c4","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lacidipine (GX-1048, GR-43659X, SN-305) is a L-type calcium channel blocker, used for treating high blood pressure.",455.54,"103890-78-4",{"v":91,"d":"91.00"},199.76,"<1","N/A","http://selleckchem.com/products/lacidipine-lacipil-motens.html","C26H33NO6","free base","GX-1048, GR-43659X, SN-305","CCOC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)\\C=C\\C(=O)OC(C)(C)C)C(=O)OCC)C",3.824,6,1,11]
["S2017","Benidipine HCl","d4","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Benidipine HCl (KW-3049,(±)- Benidipine) is a hydrochloride salt form of benidipine which is a dihydropyridine calcium channel blocker.",542.02,"91599-74-5",{"v":8,"d":"8.00"},14.76,"<1","N/A","http://selleckchem.com/products/benidipine-hydrochloride.html","C28H31N3O6.HCl","Hydrochloride","KW-3049,(±)- Benidipine","Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC3CCCN(C3)CC4=CC=CC=C4)C",{"v":4.36,"d":"4.360"},4,1,9]
["S2030","Flunarizine 2HCl","e4","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Flunarizine 2HCl (KW-3149, R14950) is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.",477.42,"30484-77-6",{"v":5,"d":"5.00"},10.47,"<1","N/A","http://selleckchem.com/products/flunarizine-dihydrochloride.html","C26H26F2N2.2HCl","2HCl","KW-3149, R14950","Cl.Cl.FC1=CC=C(C=C1)C(N2CCN(CC2)C\\C=C\\C3=CC=CC=C3)C4=CC=C(F)C=C4",6.699,0,0,6]
["S2080","Clevidipine Butyrate","f4","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Clevidipine Butyrate(Cleviprex) is a dihydropyridine calcium channel blocker,  uses as an agent for the reduction of blood pressure.",456.32,"167221-71-8",{"v":91,"d":"91.00"},199.42,"<1","N/A","http://selleckchem.com/products/cleviprex-clevidipine.html","C21H23Cl2NO6","free base","Cleviprex","CCCC(=O)OCOC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2Cl)Cl)C(=O)OC)C",4.145,6,1,10]
["S2114","Dronedarone HCl","g4","L9000-01","in 10mM DMSO","Calcium Channel,Potassium Channel,Sodium Channel","Transmembrane Transporters","Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel, sodium channel and calcium channel, used as an antiarrhythmic drug for treatment of atrial fibrillation (AF).",593.22,"141625-93-6",{"v":80,"d":"80.00"},134.86,"<1","N/A","http://selleckchem.com/products/dronedarone-hcl-multaq.html","C31H44N2O5S.HCl","HCl","SR33589","Cl.CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C2=C(CCCC)OC3=CC=C(N[S](C)(=O)=O)C=C23",7.397,5,1,18]
["S2118","Ibutilide Fumarate","h4","L9000-01","in 10mM DMSO","Sodium Channel","Transmembrane Transporters","Ibutilide Fumarate (U-70226E,Corvert Fumarate) is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.",885.23,"122647-32-9",{"v":89,"d":"89.00"},100.54,{"v":89,"d":"89.00"},100.54,"http://selleckchem.com/products/ibutilide-fumarate.html","(C20H36N2O3S)2.C4H4O4","Fumarate","U-70226E,Corvert Fumarate","CCCCCCCN(CC)CCCC(O)C1=CC=C(N[S](C)(=O)=O)C=C1.CCCCCCCN(CC)CCCC(O)C2=CC=C(N[S](C)(=O)=O)C=C2.OC(=O)\\C=C\\C(O)=O",1.954,6,4,30]
["S2403","Tetrandrine (NSC-77037)","a5","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Tetrandrine (NSC-77037, Fanchinine, d-Tetrandrine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a calcium channel blocker.",622.75,"518-34-3",{"v":7,"d":"7.00"},11.24,"<1","N/A","http://www.selleck.cn/products/Tetrandrine-Fanchinine.html","C38H42N2O6","Free Base","Fanchinine, d-Tetrandrine","COC1=CC=C2CC3N(C)CCC4=CC(=C(OC)C(=C34)OC5=C(OC)C=C6CCN(C)C(CC7=CC=C(OC1=C2)C=C7)C6=C5)OC",7.218,6,0,4]
["S2415","Astragaloside A","b5","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.",784.97,"83207-58-3",{"v":100,"d":"100.00"},127.39,"<1","N/A","http://selleckchem.com/products/astragaloside-a.html","C41H68O14","free base","N/A","CC(C)(O)C1CCC(C)(O1)C2C(O)CC3(C)C4CC(OC5OC(CO)C(O)C(O)C5O)C6C(C)(C)C(CCC67CC47CCC23C)OC8OCC(O)C(O)C8O",-0.348,5,8,7]
["S2446","Levosimendan","c5","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Levosimendan(OR1259,OR1855,Simsndan) is a calcium sensitizer acting through calcium-dependent binding to cardiac troponin C (cTnC), provides treatment for heart failure.",280.28,"141505-33-1",{"v":56,"d":"56.00"},{"v":199.8,"d":"199.80"},"<1","N/A","http://selleckchem.com/products/levosimendan.html","C14H12N6O","free base","OR1259,OR1855,Simsndan","CC1CC(=O)NN=C1C2=CC=C(NN=C(C#N)C#N)C=C2",1.486,3,2,3]
["S2481","Manidipine","d5","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Manidipine(CV-4093,(±)-Manidipine) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.",{"v":610.7,"d":"610.70"},"89226-50-6",{"v":122,"d":"122.00"},199.77,"<1","N/A","http://selleckchem.com/products/Manidipine(Manyper).html","C35H38N4O6","free base","CV-4093,(±)-Manidipine","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OCCN3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)C",5.058,4,1,12]
["S2482","Manidipine 2HCl","e5","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Manidipine 2HCl (CV-4093) is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4.",683.62,"89226-75-5",{"v":21,"d":"21.00"},30.72,"<1","N/A","http://selleckchem.com/products/Manidipine-dihydrochloride(CV-4093).html","C35H38N4O6.2HCl","Dihydrochloride","CV-4093","Cl.Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OCCN3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)C",5.822,4,1,12]
["S2491","Nitrendipine","f5","L9000-01","in 10mM DMSO","Autophagy,Calcium Channel","Transmembrane Transporters","Nitrendipine (Bayotensin) is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.",360.37,"39562-70-4",{"v":72,"d":"72.00"},199.79,"<1","N/A","http://selleckchem.com/products/Nitrendipine.html","C18H20N2O6","free base","Bayotensin","CCOC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC)C",2.115,4,1,7]
["S2535","Econazole nitrate","g5","L9000-01","in 10mM DMSO","Calcium Channel,Fungal","Transmembrane Transporters","Econazole Nitrate (NSC 243115,Spectazole) is a Ca2+ channel blocker, used as an antifungal medicine that fights infections caused by fungus.",{"v":444.7,"d":"444.70"},"24169-02-6",{"v":89,"d":"89.00"},200.13,"<1","N/A","http://selleckchem.com/products/Econazole-nitrate-Spectazole.html","C18H15Cl3N2O.HNO3","Nitrate","NSC 243115,Spectazole","O[N+]([O-])=O.ClC1=CC=C(COC(C[N]2C=CN=C2)C3=CC=C(Cl)C=C3Cl)C=C1",3.722,2,0,6]
["S2573","Tetracaine HCl","h5","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Tetracaine HCl (Amethocaine hydrochloride) is a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.",300.82,"136-47-0",{"v":60,"d":"60.00"},199.45,{"v":60,"d":"60.00"},199.45,"http://selleckchem.com/products/tetracaine-hydrochloride-pontocaine.html","C15H24N2O2.HCl","Hydrochloride","Amethocaine hydrochloride","Cl.CCCCNC1=CC=C(C=C1)C(=O)OCCN(C)C",3.343,2,1,9]
["S2721","Nilvadipine","a6","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nilvadipine (ARC029, FR34235,FK235) is a potent calcium channel blocker with an IC50 of 0.03 nM.",385.37,"75530-68-6",{"v":77,"d":"77.00"},199.81,"<1","N/A","http://selleckchem.com/products/nilvadipine-arc029.html","C19H19N3O6","free base","ARC029, FR34235,FK235","COC(=O)C1=C(NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)C)C)C#N",2.087,4,1,7]
["S2857","(-)-Dizocilpine (MK 801) Maleate","b6","L9000-01","in 10mM DMSO","NMDAR","Neuronal Signaling","(-)-Dizocilpine (MK 801, Dizocilpine, C13737) Maleate is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.",337.37,"121917-57-5",{"v":67,"d":"67.00"},{"v":198.6,"d":"198.60"},"<1","N/A","http://selleckchem.com/products/--mk-801-maleate.html","C16H15N.C4H4O4","maleate","C13737","CC12NC(CC3=C1C=CC=C3)C4=C2C=CC=C4.OC(=O)\\C=C/C(O)=O",0.376,2,1,2]
["S2860","IEM 1754 2HBr","c6","L9000-01","in 10mM DMSO","GluR","Neuronal Signaling","IEM 1754 2HBr is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.",412.25,"162831-31-4",{"v":82,"d":"82.00"},198.91,{"v":82,"d":"82.00"},198.91,"http://selleckchem.com/products/iem-1754-dihydrobromide.html","C16H30N2.2HBr","DihydrobroMide","N/A","Br.Br.NCCCCCNC[C]12C[CH]3C[CH]([CH2]C([CH2]3)C1)C2",{"v":3.51,"d":"3.510"},0,2,7]
["S2876","(+)-Dizocilpine (MK 801) Maleate","d6","L9000-01","in 10mM DMSO","NMDAR","Neuronal Signaling","(+)-Dizocilpine (MK 801) Maleate is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.",337.37,"77086-22-7",{"v":68,"d":"68.00"},201.56,"<1","N/A","http://selleckchem.com/products/mk-801-maleate.html","C16H15N.C4H4O4","maleate","N/A","CC12NC(CC3=C1C=CC=C3)C4=C2C=CC=C4.OC(=O)\\C=C/C(O)=O",0.376,2,1,2]
["S3018","Niflumic acid","e6","L9000-01","in 10mM DMSO","COX,GABA Receptor","Neuronal Signaling","Niflumic acid(Nifluril) is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.",282.22,"4394-00-7",{"v":56,"d":"56.00"},198.43,"<1","N/A","http://selleckchem.com/products/niflumic-acid.html","C13H9F3N2O2","free base","Nifluril","OC(=O)C1=CC=CN=C1NC2=CC=CC(=C2)C(F)(F)F",{"v":3.34,"d":"3.340"},2,1,4]
["S3045","Cinepazide maleate","f6","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.",533.57,"26328-04-1",{"v":107,"d":"107.00"},200.54,{"v":107,"d":"107.00"},200.54,"http://selleckchem.com/products/cinepazide-maleate.html","C22H31N3O5.C4H4O4","Maleate","N/A","COC1=C(OC)C(=CC(=C1)/C=C/C(=O)N2CCN(CC2)CC(=O)N3CCCC3)OC.OC(=O)\\C=C/C(O)=O",{"v":-1.65,"d":"-1.650"},7,0,9]
["S3053","Azelnidipine","g6","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker.",582.65,"123524-52-7",{"v":117,"d":"117.00"},200.81,"<1","N/A","http://selleckchem.com/products/azelnidipine.html","C33H34N4O6","free base","UR-12592","CC(C)OC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC3CN(C3)C(C4=CC=CC=C4)C5=CC=CC=C5)N",4.941,4,2,11]
["S3653","Spermidine trihydrochloride","h6","L9000-01","in 10mM DMSO","Autophagy,NMDAR","Neuronal Signaling","Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).",254.63,"334-50-9",{"v":30,"d":"30.00"},117.82,{"v":50,"d":"50.00"},196.36,"http://selleckchem.com/products/spermidine-trihydrochloride.html","C7H19N3.3HCl","trihydrochloride","4-Azaoctamethylenediamine trihydrochloride","Cl.Cl.Cl.NCCCCNCCCN",-0.024,0,3,7]
["S3674","Levamlodipine","a7","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Levamlodipine (S-amlodipine) is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure.",408.88,"103129-82-4",{"v":81,"d":"81.00"},{"v":198.1,"d":"198.10"},{"v":81,"d":"81.00"},{"v":198.1,"d":"198.10"},"http://selleckchem.com/products/levamlodipine.html","C20H25ClN2O5","free base","S-amlodipine","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C",1.576,5,2,10]
["S3682","Ethyl 3-Aminobenzoate methanesulfonate","b7","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ethyl 3-Aminobenzoate (Ethyl m-Aminobenzoate, NSC 93790, Tricaine) can block the generation of action potentials via voltage-dependent Na+-channels and usually used for anesthesia, sedation, or euthanasia of fish.",261.29,"886-86-2",{"v":52,"d":"52.00"},199.01,{"v":52,"d":"52.00"},199.01,"http://selleckchem.com/products/ethyl-3-aminobenzoate-methanesulfonate.html","C9H11NO2.CH4O3S","methanesulfonate","Ethyl m-Aminobenzoate, NSC 93790, Tricaine methanesulfonate","CCOC(=O)C1=CC(=CC=C1)N.C[S](O)(=O)=O",0.873,2,1,3]
["S3700","DHBP dibromide","c7","L9000-01","in 10mM DMSO","Calcium Channel,Dyes","Transmembrane Transporters","DHBP (1,1'-diheptyl-4,4'-bipyridinium), a viologen for electrochromic memory display agent, inhibits the calcium release induced by 2 mM caffeine and 2 μg/ml polylysine with an IC50 value of 5 μg/ml and 4 μg/ml respectively.",514.38,"6159-05-3",{"v":100,"d":"100.00"},194.41,{"v":100,"d":"100.00"},194.41,"http://selleckchem.com/products/dhbp-dibromide.html","C24H38N2.2Br","dibromide","1,1'-diheptyl-4,4'-bipyridinium dibromide","[Br-].[Br-].CCCCCCC[N+]1=CC=C(C=C1)C2=CC=[N+](CCCCCCC)C=C2",3.116,0,0,13]
["S3766","Tanshinone IIA sulfonate sodium","d7","L9000-01","in 10mM DMSO","Calcium Channel,P2 Receptor,P450 (e.g. CYP17)","Metabolism","Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA isolated as the main pharmacologically active natural compound from a traditional Chinese herbal medicine, the dried root of Salvia miltiorrhiza Bunge known as Danshen. Sodium tanshinone IIA sulfonate (STS) is a potent negative allosteric modulator of the human purinergic receptor P2X7. Sodium tanshinone IIA sulfonate (STS) inhibits the activity of CYP3A4 and store-operated Ca2+ entry (SOCE) through store-operated Ca2+ channels (SOCC) via downregulating the expression of transient receptor potential canonical proteins (TRPC).",396.39,"69659-80-9",{"v":79,"d":"79.00"},{"v":199.3,"d":"199.30"},"N/A","N/A","http://selleckchem.com/products/tanshinone-iia-sulfonate-sodium.html","C19H17O6S.Na","sodium salt","N/A","[Na+].CC1=C(OC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C)[S]([O-])(=O)=O",1.873,3,0,1]
["S3809","Imperatorin","e7","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Imperatorin (Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen), a naturally occurring psoralen-type furanocoumarin, is a potent myorelaxant agent and acts as a calcium antagonist on vascular smooth muscle.",270.28,"482-44-0",{"v":54,"d":"54.00"},199.79,"N/A","N/A","http://selleckchem.com/products/imperatorin.html","C16H14O4","free base","Ammidin, Marmelosin, Pentosalen, 8-Isoamylenoxypsoralen, 8-Isopentenyloxypsoralene","CC(C)=CCOC1=C2OC(=O)C=CC2=CC3=C1OC=C3",3.652,4,0,3]
["S3883","Protopine","f7","L9000-01","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Protopine (Corydinine, Fumarine, Biflorine, Macleyine), an alkaloid present in different plants, has been shown to exhibit a number of activities, such as inhibition of calcium influx through both voltage and receptor-operated channels and inhibition of rabbit blood platelet aggregation. It also possesses anti-cholinergic and anti-histaminic as well as anti-bacterial activities.",353.37,"130-86-9",{"v":30,"d":"30.00"},{"v":84.9,"d":"84.90"},"N/A","N/A","http://selleckchem.com/products/protopine.html","C20H19NO5","free base","Corydinine, Fumarine, Biflorine, Macleyine","CN1CCC2=C(C=C3OCOC3=C2)C(=O)CC4=C(C1)C5=C(OCO5)C=C4",2.953,5,0,0]
["S3931","Ginsenoside Rd","g7","L9000-01","in 10mM DMSO","Calcium Channel,COX,NF-κB,NOS,P450 (e.g. CYP17)","Immunology & Inflammation","Ginsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.",947.15,"52705-93-8",{"v":90,"d":"90.00"},95.02,"N/A","N/A","http://selleckchem.com/products/ginsenoside-rd.html","C48H82O18","free base","Panaxoside Rd, Sanchinoside Rd","CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6OC7OC(CO)C(O)C(O)C7O)C(C)(C)C5CCC34C",0.548,6,12,13]
["S3933","10-deacetyl-paclitaxel","h7","L9000-01","in 10mM DMSO","Others","Others","10-deacetyl-paclitaxel (10-DAT, Deacetyl Paclitaxel) is a semi-synthetic precursor of Paclitaxel.",811.87,"78432-77-6",{"v":27,"d":"27.00"},33.26,"N/A","N/A","http://selleckchem.com/products/10-deacetyl-paclitaxel.html","C45H49NO13","free base","10-DAT, Deacetyl Paclitaxel","CC(=O)OC12COC1CC(O)C3(C)C2C(OC(=O)C4=CC=CC=C4)C5(O)CC(OC(=O)C(O)C(NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)C(=C(C(O)C3=O)C5(C)C)C",2.676,9,4,12]
["S4057","Methyclothiazide","a8","L9000-01","in 10mM DMSO","Others","Others","Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.",360.24,"135-07-9",{"v":72,"d":"72.00"},199.87,"<1","N/A","http://selleckchem.com/products/methyclothiazide.html","C9H11Cl2N3O4S2","free base","N/A","CN1C(CCl)NC2=CC(=C(C=C2[S]1(=O)=O)[S](N)(=O)=O)Cl",0.808,4,2,2]
["S4084","Lomerizine 2HCl","b8","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lomerizine dihydrochloride (KB-2796) is a relatively new L- and T-type calcium channel blocker used in the treatment of migraine.",541.46,"101477-54-7",{"v":100,"d":"100.00"},184.69,"<1","N/A","http://selleckchem.com/products/lomerizine-hcl.html","C27H30F2N2O3.2HCl","Dihydrochloride","KB-2796","Cl.Cl.COC1=C(OC)C(=C(CN2CCN(CC2)C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C=C1)OC",6.182,3,0,8]
["S4091","Ifenprodil Tartrate","c8","L9000-01","in 10mM DMSO","NMDAR","Neuronal Signaling","Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.",800.98,"23210-58-4",{"v":95,"d":"95.00"},{"v":118.6,"d":"118.60"},{"v":9,"d":"9.00"},11.24,"http://selleckchem.com/products/ifenprodil-tartrate.html","2(C21H27NO2).C4H6O6","Tartrate","N/A","CC(C(O)C1=CC=C(O)C=C1)N2CCC(CC2)CC3=CC=CC=C3.CC(C(O)C4=CC=C(O)C=C4)N5CCC(CC5)CC6=CC=CC=C6.OC(C(O)C(O)=O)C(O)=O",0.638,2,6,13]
["S4151","Penfluridol","d8","L9000-01","in 10mM DMSO","Dopamine Receptor","Neuronal Signaling","Penfluridol (TLP-607,R-16341) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.",523.97,"26864-56-2",{"v":100,"d":"100.00"},190.85,"<1","N/A","http://selleckchem.com/products/penfluridol.html","C28H27ClF5NO","free base","TLP-607,R-16341","OC1(CCN(CCCC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1)C4=CC(=C(Cl)C=C4)C(F)(F)F",7.311,0,0,8]
["S4162","Benzethonium Chloride","e8","L9000-01","in 10mM DMSO","AChR","Neuronal Signaling","Benzethonium chloride is a potent inhibitor of nAChRs, it inhibits α4β2 nAChRs and α7 nAChRs with IC50 of 49 nM and 122 nM, respectively.",448.08,"121-54-0",{"v":90,"d":"90.00"},200.86,{"v":90,"d":"90.00"},200.86,"http://selleckchem.com/products/benzethonium-chloride.html","C27H42NO2.Cl","Chloride","N/A","[Cl-].CC(C)(C)CC(C)(C)C1=CC=C(OCCOCC[N+](C)(C)CC2=CC=CC=C2)C=C1",2.147,2,0,12]
["S4181","Nicardipine HCl","f8","L9000-01","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Nicardipine HCl (RS-69216,YC-93) is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders.",515.99,"54527-84-3",{"v":100,"d":"100.00"},{"v":193.8,"d":"193.80"},"<1","N/A","http://selleckchem.com/products/nicardipine-hcl.html","C26H29N3O6.HCl","Hydrochloride","RS-69216,YC-93","Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OCCN(C)CC3=CC=CC=C3)C",{"v":3.87,"d":"3.870"},4,1,11]
["S4202","Verapamil (CP-16533-1) HCl","g8","L9000-01","in 10mM DMSO","Calcium Channel,P450 (e.g. CYP17),P-gp","Transmembrane Transporters","Verapamil HCl (CP-16533-1,(±)-Verapamil hydrochloride) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.",491.06,"152-11-4",{"v":98,"d":"98.00"},199.57,{"v":50,"d":"50.00"},101.82,"http://selleckchem.com/products/verapami-hcl.html","C27H38N2O4.HCl","Hydrochloride","(±)-Verapamil hydrochloride","Cl.COC1=CC=C(CCN(C)CCCC(C#N)(C(C)C)C2=CC=C(OC)C(=C2)OC)C=C1OC",5.916,4,0,13]
["S4268","Flufenamic acid","h8","L9000-01","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Flufenamic Acid is an anti-inflammatory agent, and also acts as an ion channel modulator.",281.23,"530-78-9",{"v":56,"d":"56.00"},199.13,"<1","N/A","http://selleckchem.com/products/flufenamic-acid.html","C14H10F3NO2","free base","N/A","OC(=O)C1=CC=CC=C1NC2=CC=CC(=C2)C(F)(F)F",3.952,1,1,4]
["S4353","Terfenadine","a9","L9000-01","in 10mM DMSO","Calcium Channel,Caspase,Histamine Receptor,NCX,Potassium Channel","Transmembrane Transporters","Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform.  Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.",471.67,"50679-08-8",{"v":94,"d":"94.00"},199.29,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/terfenadine.html","C32H41NO2","Free Base","N/A","CC(C)(C)C1=CC=C(C=C1)C(O)CCCN2CCC(CC2)C(O)(C3=CC=CC=C3)C4=CC=CC=C4",6.498,0,1,9]
["S4505","Vinblastine (NSC-49842) sulfate","b9","L9000-01","in 10mM DMSO","AChR,Antineoplastic and Immunosuppressive Antibiotics,Apoptosis related,Autophagy,Microtubule Associated","Cytoskeletal Signaling","Vinblastine sulfate (NSC49842, Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe) inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, used to treat certain kinds of cancer. Vinblastine sulfate induces autophagy and apoptosis.",909.05,"143-67-9",{"v":100,"d":"100.00"},{"v":110,"d":"110.00"},"<1","N/A","http://selleckchem.com/products/vinblastine-sulfate.html","C46H58N4O9.H2SO4","sulfate","Vincaleukoblastine sulfate salt, 29060-LE, Exal, Velban, Velbe","CCC1(O)CC2CN(CCC3=C([NH]C4=CC=CC=C34)C(C2)(C(=O)OC)C5=C(OC)C=C6N(C)C7C(O)(C(OC(C)=O)C8(CC)C=CCN9CCC7(C89)C6=C5)C(=O)OC)C1.O[S](O)(=O)=O",{"v":4.28,"d":"4.280"},7,1,10]
["S4597","Lercanidipine hydrochloride","c9","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lercanidipine is a calcium channel blocker of the dihydropyridine class.",648.19,"132866-11-6",{"v":66,"d":"66.00"},101.82,"<1","N/A","http://selleckchem.com/products/lercanidipine-hydrochloride.html","C36H41N3O6.HCl","hydrochloride","Zanidip (hydrochloride), Masnidipine (hydrochloride)","Cl.COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)(C)CN(C)CCC(C3=CC=CC=C3)C4=CC=CC=C4)C",6.514,4,1,14]
["S4626","Ethosuximide","d9","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ethosuximide(Zarontin) is a succinimide anticonvulsant, used mainly in absence seizures; A calcium channel blocker.",141.17,"77-67-8",{"v":28,"d":"28.00"},198.34,{"v":28,"d":"28.00"},198.34,"http://selleckchem.com/products/ethosuximide.html","C7H11NO2","free base","Zarontin","CCC1(C)CC(=O)NC1=O",0.543,2,1,1]
["S4648","Dantrolene sodium hemiheptahydrate","e9","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Dantrolene sodium hemiheptahydrate (Dantrium) is a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.",399.29,"24868-20-0",{"v":14,"d":"14.00"},35.06,"<1","N/A","https://www.selleckchem.com/products/dantrolene-sodium-s4648.html","C14H9N4O5.7/2H2O.Na","Sodium salt hemiheptahydrate","Dantrolene sodium salt, Dantrium, Sodium dantrolene","CCC1CN2CCC1CC2C(O)C3=C4C=C(OC)C=CC4=NC=C3",3.124,2,1,4]
["S4714","(-)-Menthol","f9","L9000-01","in 10mM DMSO","TRP Channel","Transmembrane Transporters","(-)-Menthol is a levo isomer of menthol and used as a cooling agent that strongly activates TRPM8.",156.27,"2216-51-5",{"v":31,"d":"31.00"},198.37,{"v":16,"d":"16.00"},102.39,"http://selleckchem.com/products/-menthol.html","C10H20O","free base","L-Menthol, Levomenthol, Menthomenthol, Menthacamphor","CC(C)C1CCC(C)CC1O",2.779,0,1,1]
["S4716","Evans Blue","g9","L9000-01","in 10mM DMSO","GluR","Neuronal Signaling","Evans Blue (Direct Blue 53,C.I.23860) is a potent inhibitor of the uptake of L-glutamate into synaptic vesicles, also an AMPA/kainate receptor antagonist.",960.81,"314-13-6",{"v":100,"d":"100.00"},104.08,{"v":100,"d":"100.00"},104.08,"http://selleckchem.com/products/evans-blue.html","C34H24N6O14S4.4Na","sodium salt","Direct Blue 53,C.I.23860","CC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=NC3=C(O)C4=C(N)C(=CC(=C4C=C3)[S](=O)(=O)O[Na])[S](=O)(=O)O[Na])C)N=NC5=C(O)C6=C(N)C(=CC(=C6C=C5)[S](=O)(=O)O[Na])[S](=O)(=O)O[Na]",6.593,8,4,13]
["S4719","Kynurenic acid","h9","L9000-01","in 10mM DMSO","NMDAR","Neuronal Signaling","Kynurenic acid (Quinurenic acid, Kynurenate), a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA\n\nreceptors.",189.17,"492-27-3",{"v":10,"d":"10.00"},52.86,"<1","N/A","http://selleckchem.com/products/kynurenic-acid.html","C10H7NO3","free base","Quinurenic acid, Kynurenate","OC(=O)C1=CC(=C2C=CC=CC2=N1)O",1.832,2,1,1]
["S4727","Cinnarizine","a10","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Cinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine) is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker.",368.51,"298-57-7",{"v":73,"d":"73.00"},{"v":198.1,"d":"198.10"},"<1","N/A","http://selleckchem.com/products/cinnarizine.html","C26H28N2","free base","Stugeron, Dimitronal, Stutgin, Cinarizine","C1CN(CCN1C\\C=C\\C2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4",5.524,0,0,6]
["S4902","QNZ (EVP4593)","b10","L9000-01","in 10mM DMSO","NF-κB,TNF-alpha","NF-κB","QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.",356.42,"545380-34-5",{"v":5,"d":"5.00"},14.03,"<1","N/A","http://selleckchem.com/products/qnz-evp4593.html","C22H20N4O","free base","N/A","NC1=CC2=C(NCCC3=CC=C(OC4=CC=CC=C4)C=C3)N=CN=C2C=C1",4.454,3,2,6]
["S4931","Propiverine hydrochloride","c10","L9000-01","in 10mM DMSO","AChR,Calcium Channel","Transmembrane Transporters","Propiverine is an anticholinergic drug used for the treatment of overactive bladder and urinary incontinence. Propiverine is a muscarinic receptor antagonist possessing additional properties, i.e., block of L-type Ca2+ channels.",403.94,"54556-98-8",{"v":80,"d":"80.00"},198.05,"N/A","N/A","http://selleckchem.com/products/propiverine-hydrochloride.html","C23H29NO3.ClH","HCl","N/A","Cl.CCCOC(C(=O)OC1CCN(C)CC1)(C2=CC=CC=C2)C3=CC=CC=C3",4.388,3,0,8]
["S4957","Linalool","d10","L9000-01","in 10mM DMSO","NMDAR","Neuronal Signaling","Linalool (Phantol), a monoterpene compound commonly found as major component of essential oils of several aromatic species, is a competitive antagonist of NMDA receptors.",154.25,"78-70-6","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://selleckchem.com/products/linalool.html","C10H18O","free base","Phantol","CC(C)=CCCC(C)(O)C=C",2.735,0,0,4]
["S4977","Efonidipine","e10","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Efonidipine (NZ-105) is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. It also suppresses aldosterone secretion from the adrenal.",631.66,"111011-63-3",{"v":100,"d":"100.00"},158.31,"N/A","N/A","http://selleckchem.com/products/efonidipine.html","C34H38N3O7P","free base","NZ-105","CC1=C(C(C2=CC(=CC=C2)[N+]([O-])=O)C(=C(C)N1)[P]3(=O)OCC(C)(C)CO3)C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5",4.956,4,1,11]
["S5032","Mephenesin","f10","L9000-01","in 10mM DMSO","NMDAR","Neuronal Signaling","Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.",182.22,"59-47-2",{"v":36,"d":"36.00"},197.56,{"v":30,"d":"30.00"},164.64,"http://selleckchem.com/products/mephenesin.html","C10H14O3","free base","Decontractyl, Cresoxydiol, Memphenesin, Mephedan","CC1=C(OCC(O)CO)C=CC=C1",1.249,1,2,4]
["S5042","Bevantolol hydrochloride","g10","L9000-01","in 10mM DMSO","Adrenergic Receptor","Neuronal Signaling","Bevantolol hydrochloride (NC-1400) is a cardioselective, beta adrenoceptor antagonist, devoid of intrinsic β sympathomimetic activity and with weak membrane-stabilizing and local anesthetic properties.",381.89,"42864-78-8",{"v":76,"d":"76.00"},199.01,{"v":52,"d":"52.00"},136.16,"http://selleckchem.com/products/bevantolol-hydrochloride.html","C20H27NO4.HCl","hydrochloride","NC-1400 hydrochloride","Cl.COC1=C(OC)C=C(CCNCC(O)COC2=CC=CC(=C2)C)C=C1",3.645,3,2,10]
["S5164","Chlorotetracycline","h10","L9000-01","in 10mM DMSO","Anti-infection","Microbiology","Chlortetracycline is a tetracycline antibiotic and commonly used to treat conjunctivitis in cats.",478.88,"57-62-5",{"v":6,"d":"6.00"},12.53,"N/A","N/A","http://selleckchem.com/products/chlorotetracycline.html","C22H23ClN2O8","free base","N/A","CN(C)C1C2CC3C(=C(O)C2(O)C(=O)C(=C1O)C(N)=O)C(=O)C4=C(C(=CC=C4O)Cl)C3(C)O",{"v":0,"d":"0.000"},0,0,0]
["S5255","Nicardipine","a11","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Nicardipine is a potent calcium channel blockader with marked vasodilator action.",479.52,"55985-32-5",{"v":95,"d":"95.00"},198.11,{"v":30,"d":"30.00"},62.56,"https://www.selleckchem.com/products/nicardipine.html","C26H29N3O6","Dihydropyridine calcium channel blocker","YC-93","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OCCN(C)CC3=CC=CC=C3)C",3.488,4,1,11]
["S5279","Fendiline hydrochloride","b11","L9000-01","in 10mM DMSO","Calcium Channel,Ras","Transmembrane Transporters","Fendiline hydrochloride is the hydrochloride salt form of Fendiline, which is an L-type calcium channel blocker and also a specific inhibitor of K-Ras plasma membrane targeting with no detectable effect on the localization of H- and N-Ras.",351.91,"13636-18-5",{"v":70,"d":"70.00"},198.91,"N/A","N/A","http://selleckchem.com/products/fendiline-hydrochloride.html","C23H25N.HCl","hydrochloride","N/A","Cl.CC(NCCC(C1=CC=CC=C1)C2=CC=CC=C2)C3=CC=CC=C3",5.772,0,1,7]
["S5478","Dantrolene sodium","c11","L9000-01","in 10mM DMSO","ADC Cytotoxin,Calcium Channel","Transmembrane Transporters","Dantrolene sodium(F 440) acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.",336.23,"14663-23-1",{"v":67,"d":"67.00"},199.27,{"v":-1,"d":"-1.00"},-2.97,"https://www.selleckchem.com/products/s5478-dantrolene-sodium.html","C14H9N4NaO5","free base","F 440","[Na+].[O-]C1=NC(=O)CN1/N=C/C2=CC=C(O2)C3=CC=C(C=C3)[N+]([O-])=O",1.769,4,0,4]
["S5514","Lanthanum(III) chloride heptahydrate","d11","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lanthanum(III) chloride is the inorganic compound used in biochemical research to block the activity of divalent cation channels, mainly calcium channels.",371.37,"10025-84-0",{"v":50,"d":"50.00"},134.64,"N/A","N/A","http://selleckchem.com/products/lanthanum-iii-chloride-heptahydrate.html","Cl3La.7H2O","salt","N/A","O.O.O.O.O.O.O.Cl[La](Cl)Cl",0.006,0,0,0]
["S5561","Ethacrynic Acid","e11","L9000-01","in 10mM DMSO","Others","NF-κB","Ethacrynic Acid is a loop or high ceiling diuretic used for the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.",303.14,"58-54-8",{"v":61,"d":"61.00"},201.23,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/ethacrynic-acid.html","C13H12Cl2O4","Free Base","N/A","CCC(=C)C(=O)C1=C(Cl)C(=C(OCC(O)=O)C=C1)Cl",3.963,3,0,6]
["S5567","Trimethadione","f11","L9000-01","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Trimethadione is an oxazolidinedione anticonvulsant and often used to treat epileptic conditions that are resistant to other treatments.",143.14,"127-48-0",{"v":28,"d":"28.00"},195.61,"N/A","N/A","http://selleckchem.com/products/trimethadione.html","C6H9NO3","oxazolidinedione","N/A","CN1C(=O)OC(C)(C)C1=O",0.488,3,0,0]
["S5664","Orphenadrine Hydrochloride","g11","L9000-01","in 10mM DMSO","NMDAR","Neuronal Signaling","Orphenadrine Hydrochloride is an uncompetitive NMDAR antagonist, H1 receptor antagonist and nonselective mAChR antagonist with muscle relaxant activity.",305.84,"341-69-5",{"v":61,"d":"61.00"},199.45,{"v":-1,"d":"-1.00"},-3.27,"https://www.selleckchem.com/products/orphenadrine-hydrochloride.html","C18H24ClNO","free base","N/A","Cl.CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2C",4.253,1,0,6]
["S5787","Dronedarone","h11","L9000-01","in 10mM DMSO","Adrenergic Receptor","Transmembrane Transporters","Dronedarone (SR33589) is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV).",556.76,"141626-36-0","The physical form of the compound is liquid, which can be dissolved in any proportion.","N/A","N/A","N/A","http://www.selleckchem.com/products/dronedarone.html","C31H44N2O5S","Free Base","SR33589","CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C2=C(CCCC)OC3=C2C=C(N[S](C)(=O)=O)C=C3",7.015,5,1,18]
["S5861","Lercanidipine","a2","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Lercanidipine is a vasoselective dihydropyridine calcium antagonist used for the treatment of essential hypertension.",611.73,"100427-26-7",{"v":55,"d":"55.00"},89.91,{"v":1,"d":"1.00"},1.63,"http://www.selleckchem.com/products/lercanidipine.html","C36H41N3O6","Free Base","N/A","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC(C)(C)CN(C)CCC(C3=CC=CC=C3)C4=CC=CC=C4)C",6.132,4,1,14]
["S6410","Clemizole","b2","L9000-02","in 10mM DMSO","Dopamine Receptor,TRP Channel","Neuronal Signaling","Clemizole, a first-generation histamine receptor (H1) antagonist, is a potent inhibitor of behavioural and electrographic seizure activity. It has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels.",325.84,"442-52-4",{"v":65,"d":"65.00"},199.48,{"v":-1,"d":"-1.00"},"N/A","http://www.selleck.cn/products/clemizole.html","C19H20ClN3","Free Base","N/A","ClC1=CC=C(C[N]2C(=NC3=C2C=CC=C3)CN4CCCC4)C=C1",4.527,1,0,4]
["S6473","Pinaverium bromide","c2","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Pinaverium bromide (Icosapentaenoic acid) acts as a calcium channel blocker and is useful for functional gastrointestinal disorders.",591.42,"53251-94-8",{"v":100,"d":"100.00"},169.08,{"v":16,"d":"16.00"},27.05,"http://www.selleck.cn/products/pinaverium-bromide.html","C26H41Br2NO4","bromide","Icosapentaenoic acid","[Br-].COC1=C(OC)C=C(C[N+]2(CCOCCC3CCC4CC3C4(C)C)CCOCC2)C(=C1)Br",1.114,4,0,10]
["S7392","Loxistatin Acid (E-64C)","d2","L9000-02","in 10mM DMSO","COVID-19,Cysteine Protease","Proteases","Loxistatin Acid (E-64C, NSC 694279, EP 475), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry.",314.38,"76684-89-4",{"v":62,"d":"62.00"},197.21,{"v":2,"d":"2.00"},6.36,"http://selleckchem.com/products/loxistatin-acid-e-64c.html","C15H26N2O5","free base","NSC 694279, EP 475","CC(C)CCNC(=O)C(CC(C)C)NC(=O)C1OC1C(O)=O",1.037,4,2,9]
["S7924","Bay K 8644","e2","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.",{"v":356.3,"d":"356.30"},"71145-03-4",{"v":71,"d":"71.00"},199.27,"<1","N/A","http://selleckchem.com/products/bay-k-8644.html","C16H15F3N2O4","free base","N/A","COC(=O)C1=C(C)NC(=C(C1C2=C(C=CC=C2)C(F)(F)F)[N+]([O-])=O)C",2.673,2,1,5]
["S7999","SKF96365","f2","L9000-02","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SKF96365, originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically, as a blocker of transient receptor potential canonical type (TRPC) channels.",402.91,"130495-35-1",{"v":80,"d":"80.00"},198.56,{"v":80,"d":"80.00"},198.56,"http://selleckchem.com/products/skf96365.html","C22H26N2O3.HCl","hydrochloride","N/A","Cl.COC1=CC=C(CCCOC(C[N]2C=CN=C2)C3=CC=C(OC)C=C3)C=C1",4.114,4,0,10]
["S8208","Hydroxyfasudil (HA-1100) HCl","g2","L9000-02","in 10mM DMSO","ROCK","Cell Cycle","Hydroxyfasudil (HA-1100), an active metabolite of fasudil hydrochloride, is a specific Rho-kinase(ROCK) inhibitor with IC50 values of 0.73 μM and 0.72 μM for ROCK1 and ROCK2, respectively.",343.83,"155558-32-0 (HCl salt)",{"v":68,"d":"68.00"},197.77,{"v":60,"d":"60.00"},{"v":174.5,"d":"174.50"},"http://selleckchem.com/products/hydroxyfasudil-ha-1100.html","C14H17N3O3S.HCl.xH2O","hydrochloride","N/A","Cl.O=C1NC=CC2=C1C=CC=C2[S](=O)(=O)N3CCCNCC3",0.443,3,2,2]
["S8380","YM-58483 (BTP2)","h2","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","YM-58483/BTP2 is a blocker of store-operated Ca2+ entry (SOCE), which regulates the activation of non-excitable cells such as lymphocytes.",421.32,"223499-30-7",{"v":84,"d":"84.00"},199.37,"<1","N/A","http://selleckchem.com/products/ym-58483-btp2.html","C15H9F6N5OS","free base","N/A","CC1=C(SN=N1)C(=O)NC2=CC=C(C=C2)[N]3N=C(C=C3C(F)(F)F)C(F)(F)F",4.564,4,1,5]
["S8388","ML-7 HCl","a3","L9000-02","in 10mM DMSO","MLCK,PKA,PKC","Cytoskeletal Signaling","ML-7 is an inhibitor of smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 µM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. ML-7 also inhibits PKA and PKC with Ki of 21 μM and 42 μM, respectively.",452.74,"110448-33-4",{"v":90,"d":"90.00"},198.79,"<1","N/A","http://selleckchem.com/products/ml-7.html","C15H17IN2O2S.HCl","hydrochloride","N/A","Cl.IC1=C2C=CC=C(C2=CC=C1)[S](=O)(=O)N3CCCNCC3",2.299,2,1,2]
["S8691","ML204","b3","L9000-02","in 10mM DMSO","TRP Channel","Transmembrane Transporters","ML204 is a novel, potent, and selective TRPC4 channel inhibitor with apparent IC50 values of about 1 μM in fluorescent intracellular Ca2+ assays and about 3 μM in whole-cell voltage clamp experiments. It exhibits some selectivity within the TRPC subfamily of channels and higher selectivity against other TRP channels and non-TRP channels.",226.32,"5465-86-1",{"v":45,"d":"45.00"},198.83,"N/A","N/A","http://selleckchem.com/products/ml204.html","C15H18N2","free base","N/A","CC1=CC(=NC2=CC=CC=C12)N3CCCCC3",4.121,1,0,1]
["S9100","Fraxinellone","c3","L9000-02","in 10mM DMSO","Immunology & Inflammation related","Immunology & Inflammation","Fraxinellone is a natural product isolated from the D. dasycarpus plant, which has been shown to exhibit neuroprotective and anti-inflammatory activities.",232.27,"28808-62-0",{"v":46,"d":"46.00"},198.04,"N/A","N/A","https://www.selleckchem.com/products/fraxinellone.html","C14H16O3","free base","N/A","CC1=C2C(=O)OC(C3=COC=C3)C2(C)CCC1",2.995,3,0,1]
["S9141","Berbamine","d3","L9000-02","in 10mM DMSO","Apoptosis related,Bcr-Abl,CaMK,NF-κB","Angiogenesis","Berbamine (BA), a traditional Chinese medicines extracted from Berberis amurensis (xiaoboan), is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine (BA) induces apoptosis in human myeloma cells and inhibits the growth of cancer cells by targeting Ca²⁺/calmodulin-dependent protein kinase II (CaMKII).",608.72,"478-61-5",{"v":100,"d":"100.00"},164.28,"N/A","N/A","https://www.selleckchem.com/products/berbamine.html","C37H40N2O6","free base","BA, BBM","COC1=C2OC3=C4C(CC5=CC=C(O)C(=C5)OC6=CC=C(CC7N(C)CCC(=C1)C7=C2)C=C6)N(C)CCC4=CC(=C3OC)OC",6.992,5,1,3]
["S9151","Praeruptorin E","e3","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Praeruptorin E, isolated from Peucedanum praeruptorum Dunn., is a cardiotonic agent with selective cardiac calcium channel agonistic effect.",428.47,"78478-28-1",{"v":34.6,"d":"34.60"},80.75,"N/A","N/A","https://www.selleckchem.com/products/praeruptorin-e.html","C24H28O7","free base","N/A","C\\C=C(C)/C(=O)OC1C(OC(=O)CC(C)C)C2=C3OC(=O)C=CC3=CC=C2OC1(C)C",4.877,7,0,7]
["S9179","Catharanthine hemitartrate","f3","L9000-02","in 10mM DMSO","AChR","Neuronal Signaling","Catharanthine hemitartrate is the starting material for the synthesis of the antitumor drugs vinblastine and vincristine.",822.94,"4168-17-6",{"v":97,"d":"97.00"},199.38,"N/A","N/A","https://www.selleckchem.com/products/catharanthine-hemitartrate.html","C46H54N4O10","free base","N/A","CCC1=CC2CN3CCC4=C([NH]C5=C4C=CC=C5)C(C2)(C13)C(=O)OC.OC(C(O)C(O)=O)C(O)=O",-0.822,4,3,6]
["S9315","Praeruptorin A","g3","L9000-02","in 10mM DMSO","Akt,Calcium Channel,p38 MAPK","PI3K/Akt/mTOR","Praeruptorin A, a naturally existing pyranocumarin, is isolated from the dried root of Peucedanum praeruptorum Dunn. Praeruptorin A inhibits p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. Praeruptorin A can significantly upregulates multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro, and this should be taken as an herb-drug interaction.",{"v":386.4,"d":"386.40"},"73069-25-7",{"v":77,"d":"77.00"},199.28,"N/A","N/A","https://www.selleckchem.com/products/praeruptorin-a-1.html","C21H22O7","free base","N/A","C\\C=C(C)/C(=O)OC1C(OC(C)=O)C2=C(OC1(C)C)C=CC3=C2OC(=O)C=C3",3.502,7,0,5]
["S9400","Rhynchophylline","h3","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Rhynchophylline (Mitrinermine), an active component isolated from species of the genus Uncaria, acts as a calcium channel blocker and is widely used in traditional Chinese medicine mainly for treating ailments of central nervous and cardiovascular systems, such as lightheadedness, convulsions, numbness, and hypertension.",384.47,"76-66-4",{"v":76,"d":"76.00"},197.68,"N/A","N/A","https://www.selleckchem.com/products/rhynchophylline.html","C22H28N2O4","free base","Mitrinermine","CCC1CN2CCC3(C2CC1\\C(=C/OC)C(=O)OC)C(=O)NC4=CC=CC=C34",2.103,4,1,5]
["S9409","Kavain","a4","L9000-02","in 10mM DMSO","GABA Receptor","Neuronal Signaling","Kavain ((+)-Kavain), the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. Kavain positively modulated γ-Aminobutyric acid type A (GABAA) receptor.",230.26,"500-64-1",{"v":46,"d":"46.00"},199.77,"N/A","N/A","https://www.selleckchem.com/products/kavain.html","C14H14O3","free base","(+)-Kavain","COC1=CC(=O)OC(C1)\\C=C\\C2=CC=CC=C2",2.218,3,0,3]
["S9459","Mecamylamine Hydrochloride","b4","L9000-02","in 10mM DMSO","AChR","Neuronal Signaling","Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine hydrochloride is also a ganglionic blocker. Mecamylamine hydrochloride can across the blood-brain barrier. Mecamylamine hydrochloride can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area.",203.75,"826-39-1",{"v":41,"d":"41.00"},201.23,{"v":-1,"d":"-1.00"},"N/A","N/A","C11H21N · HCl","Hydrochloride","N/A","Cl.CNC1(C)C2CCC(C2)C1(C)C",2.565,0,1,1]
["S9487","Praeruptorin C","c4","L9000-02","in 10mM DMSO","Others","Others","Praeruptorin C is a natural compound derived from the dried roots of Peucedanum praeruptorum and has beneficial effects in suppressing osteoclast formation and resorption function. It is frequently utilized in traditional Chinese medicine for treating upper respiratory infections and as an antipyretic, antitussive, and mucolytic agent.",428.47,"72463-77-5",{"v":86,"d":"86.00"},200.71,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/praeruptorin-c.html","C24H28O7","Free Base","N/A","C\\C=C(C)/C(=O)OC1C(OC(=O)CC(C)C)C2=C(OC1(C)C)C=CC3=C2OC(=O)C=C3",4.877,7,0,7]
["S9566","Bepridil hydrochloride","d4","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Bepridil hydrochloride(CERM 1978) is an anti-anginal drug classified as a calcium channel blocker. It also blocks multiple other ion channels, including sodium and potassium channels.",421.02,"74764-40-2",{"v":41,"d":"41.00"},97.38,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/bepridil-hydrochloride.html","C24H37ClN2O2","hydrochloride","CERM 1978","O.Cl.CC(C)COCC(CN(CC1=CC=CC=C1)C2=CC=CC=C2)N3CCCC3",5.439,1,0,10]
["S6637","HC-067047","e4","L9000-02","in 10mM DMSO","TRP Channel","Transmembrane Transporters","HC-067047 is a selective TRPV4 channel antagonist with IC50 values of 48 nM,133 nM,and 17 nM for human, rat, and mouse TRPV4 orthologs,respectively.",471.51,"883031-03-6",{"v":94,"d":"94.00"},199.36,"<1","N/A","http://www.selleck.cn/products/hc-067047.html","C26H28F3N3O2","Free Base","N/A","CC1=C(C=C([N]1CCCN2CCOCC2)C3=CC=CC=C3)C(=O)NC4=CC=CC(=C4)C(F)(F)F",{"v":4.7,"d":"4.700"},2,1,8]
["S6638","AMG-333","f4","L9000-02","in 10mM DMSO","TRP Channel","Transmembrane Transporters","AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8.",453.32,"1416799-28-4",{"v":91,"d":"91.00"},200.74,"<1","N/A","http://www.selleck.cn/products/amg-333.html","C20H12F5N3O4","Free Base","N/A","OC(=O)C1=CN=C(C=C1)C(=O)NC(C2=CC(=C(OC(F)(F)F)C=C2)F)C3=C(F)C=CC=N3",4.843,5,1,7]
["S6644","Radiprodil (RGH-896)","g4","L9000-02","in 10mM DMSO","NMDAR","Neuronal Signaling","Radiprodil (RGH-896) is a NR2B-selective NMDA receptor antagonist, initially developed for the treatment of neuropathic pain.",{"v":397.4,"d":"397.40"},"496054-87-6",{"v":79,"d":"79.00"},198.79,"<1","N/A","http://www.selleck.cn/products/radiprodil.html","C21H20FN3O4","Free Base","N/A","FC1=CC=C(CC2CCN(CC2)C(=O)C(=O)NC3=CC4=C(NC(=O)O4)C=C3)C=C1",2.883,4,2,4]
["S2436","Pranidipine","h4","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Pranidipine (Acalas, OPC 13340) is a new 1,4-dihydropyridine calcium channel blocker. Pranidipine can enhance cyclic GMP-independent nitric oxide-induced relaxation of the rat aorta.",448.47,"99522-79-9",{"v":90,"d":"90.00"},200.68,"<1","N/A","http://www.selleck.cn/products/pranidipine.html","C25H24N2O6","Free Base","Acalas, OPC 13340","COC(=O)C1=C(C)NC(=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OC\\C=C\\C3=CC=CC=C3)C",3.817,4,1,9]
["S6634","SAR7334","a5","L9000-02","in 10mM DMSO","TRP Channel","Transmembrane Transporters","SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.9 nM in patch-clamp experiment.",367.87,"1333210-07-3",{"v":74,"d":"74.00"},201.16,"<1","N/A","http://www.selleck.cn/products/sar7334.html","C21H22ClN3O","Free Base","N/A","NC1CCCN(C1)C2CC3=C(C=CC=C3)C2OC4=CC=C(C=C4Cl)C#N",3.871,1,1,3]
["S6657","2-Aminoethyl Diphenylborinate (2-APB)","b5","L9000-02","in 10mM DMSO","Calcium Channel,TRP Channel","Transmembrane Transporters","2-Aminoethyl Diphenylborinate (2-APB) is an IP3 receptor inhibitor and regulate IP3-induced calcium release.2-APB also inhibits the SOC channel activity and activates TRP channel at higher concentrations.",225.09,"524-95-8",{"v":45,"d":"45.00"},199.92,"<1","N/A","http://www.selleck.cn/products/2-aminoethyl-diphenylborinate.html","C14H16BNO","Free Base","N/A","NCCOB(C1=CC=CC=C1)C2=CC=CC=C2",3.656,1,1,5]
["S6676","Ebselen","c5","L9000-02","in 10mM DMSO","COVID-19,HIV","Microbiology","Ebselen (DR 3305, SPI-1005, PZ-51, CCG-39161) is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay.",274.18,"60940-34-3",{"v":55,"d":"55.00"},{"v":200.6,"d":"200.60"},"<1","N/A","http://www.selleck.cn/products/ebselen.html","C13H9NOSe","Free Base","DR 3305, SPI-1005, PZ-51, CCG-39161","O=C1N([Se]C2=C1C=CC=C2)C3=CC=CC=C3",3.227,1,0,1]
["S2650","RN-1734","d5","L9000-02","in 10mM DMSO","TRP Channel","Transmembrane Transporters","RN-1734 (TRPV4 Antagonist I) is a selective transient receptor potential vanilloid 4 (TRPV4) antagonist with IC50 of 2.3 μM, 5.9 μM and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1734 alleviates demyelination and inhibits glial activation and the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.",353.31,"946387-07-1",{"v":71,"d":"71.00"},200.96,"<1","N/A","http://www.selleckchem.com/products/rn-1734.html","C14H22Cl2N2O2S","Free Base","TRPV4 Antagonist I","CC(C)NCCN(C(C)C)[S](=O)(=O)C1=CC=C(Cl)C=C1Cl",3.331,2,1,7]
["S6815","CDN1163","e5","L9000-02","in 10mM DMSO","ATPase","Transmembrane Transporters","CDN1163 is a small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) that improves Ca2+ homeostasis.",320.39,"892711-75-0",{"v":64,"d":"64.00"},199.76,"<1","N/A","http://www.selleckchem.com/products/cdn1163.html","C20H20N2O2","Free Base","N/A","CC(C)OC1=CC=C(C=C1)C(=O)NC2=CC=CC3=CC=C(C)N=C23",3.793,3,1,4]
["S6838","BCTC","f5","L9000-02","in 10mM DMSO","TRP Channel","Transmembrane Transporters","BCTC is an orally effective and highly potent vanilloid receptor 1 (VR1/TRPV1) antagonist. BCTC inhibits capsaicin-induced and acid-induced activation of rat VR1 with IC50 of 35 nM and 6.0 nM, respectivley. BCTC exhibits anti-tumor activity.",372.89,"393514-24-4",{"v":74,"d":"74.00"},198.45,"˂1","N/A","http://www.selleckchem.com/products/bctc.html","C20H25ClN4O","Free Base","N/A","CC(C)(C)C1=CC=C(NC(=O)N2CCN(CC2)C3=NC=CC=C3Cl)C=C1",4.234,2,1,3]
["S0016","SN-6","g5","L9000-02","in 10mM DMSO","AChR,Calcium Channel,NCX,Sodium Channel","Transmembrane Transporters","SN-6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 inhibits NCX1, NCX2, and NCX3 with IC50 of 2.9 μM, 16 μM and 8.6 μM, respectively. SN-6 abolishes acetylcholine (ACh)-induced vasodilation.",402.46,"415697-08-4",{"v":80,"d":"80.00"},198.78,"<1","N/A","http://www.selleckchem.com/products/sn-6.html","C20H22N2O5S","free base","N/A","CCOC(=O)C1CSC(CC2=CC=C(OCC3=CC=C(C=C3)[N+]([O-])=O)C=C2)N1",3.715,3,1,9]
["S0174","TRPM8 antagonist 2","h5","L9000-02","in 10mM DMSO","TRP Channel","Transmembrane Transporters","TRPM8 antagonist 2 (TRPM8 Antagonist) is a potent and selective antagonist of TRPM8 with IC50 of 0.2 nM that can be used for the pharmacological treatment of neuropathic pain syndromes.",{"v":398.5,"d":"398.50"},"259674-19-6",{"v":80,"d":"80.00"},200.75,"<1","N/A","http://www.selleckchem.com/products/trpm8-antagonist-2.html","C26H26N2O2","free base","TRPM8 Antagonist","COC(=O)C(CC1=C[NH]C2=CC=CC=C12)N(CC3=CC=CC=C3)CC4=CC=CC=C4",5.527,2,1,9]
["S0405","AF-353","a6","L9000-02","in 10mM DMSO","P2 Receptor","Neuronal Signaling","AF-353 (Ro-4) is a potent, selective and orally bioavailable antagonist of P2X3 receptor and P2X2/3 receptor with pIC50 of 8.06, 8.05 and 7.41 for human P2X3, rat P2X3 and human P2X2/3, respectively.",400.21,"865305-30-2",{"v":100,"d":"100.00"},249.87,"<1","N/A","http://www.selleckchem.com/products/af353.html","C14H17IN4O2","free base","Ro-4","COC1=C(I)C=C(OC2=CN=C(N)N=C2N)C(=C1)C(C)C",2.934,4,2,4]
["S0758","BX430","b6","L9000-02","in 10mM DMSO","P2 Receptor","Neuronal Signaling","BX430 is a potent and selective noncompetitive allosteric antagonist of human P2X4 receptor channels with IC50 of 0.54 μM. BX430 is a potent antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 orthologs. BX430 is used for chronic pain and cardiovascular disease.",413.11,"688309-70-8",{"v":83,"d":"83.00"},200.92,"<1","N/A","http://www.selleckchem.com/products/bx430.html","C15H15Br2N3O","free base","N/A","CC(C)C1=CC(=C(NC(=O)NC2=CC=CN=C2)C(=C1)Br)Br",4.063,2,2,3]
["S0973","Wilforgine","c6","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Wilforgine, one of the major bioactive sesquiterpene alkaloids in Tripterygium wilfordii Hook. F., induces microstructural and ultrastructural changes in the muscles of M. separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system.",857.81,"37239-47-7",{"v":100,"d":"100.00"},116.58,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/wilforgine.html","C41H47NO19","free base","N/A","CC1CCC2=C(C=CC=N2)C(=O)OCC3(C)OC45C(OC(C)=O)C3C(OC(C)=O)C(OC(C)=O)C4(COC(C)=O)C(OC(C)=O)C(OC(=O)C6=COC=C6)C(OC1=O)C5(C)O",0.609,19,0,14]
["S3217","Brilliant Blue G","d6","L9000-02","in 10mM DMSO","Dyes,P2 Receptor","Neuronal Signaling","Brilliant Blue G (BBG) is a potent non-competitive antagonist of P2X7 receptor with IC50 of 10.1 nM and 265 nM for rat P2X7 and human P2X7, respectively. Brilliant Blue G is a dye which is commonly used in laboratories to stain or quantify proteins.",854.02,"6104-58-1",{"v":100,"d":"100.00"},117.09,{"v":100,"d":"100.00"},117.09,"http://www.selleckchem.com/products/brilliant-blue-g.html","C47H48N3NaO7S2","free base","BBG","[Na+].CCOC1=CC=C(NC2=CC=C(C=C2)\\C(C3=CC=C(C=C3C)N(CC)CC4=CC=CC(=C4)[S]([O-])(=O)=O)=C/5C=CC(/C=C5C)=[N+](/CC)CC6=CC=CC(=C6)[S]([O-])(=O)=O)C=C1",5.617,1,1,15]
["S3236","Mesaconitine","e6","L9000-02","in 10mM DMSO","Apoptosis related,Calcium Channel,TNF-alpha","Transmembrane Transporters","Mesaconitine, one of the aconite alkaloids in Aconiti tuber, increases the [Ca2+]i level in endothelial cells by influx of Ca2+ from extracellular spaces.",631.71,"2752-64-9",{"v":12,"d":"12.00"},{"v":19,"d":"19.00"},{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/mesaconitine.html","C33H45NO11","free base","N/A","COCC12CN(C)C3C4C(OC)C1C3(C(CC2O)OC)C5CC6(O)C(OC)C(O)C4(OC(C)=O)C5C6OC(=O)C7=CC=CC=C7",-1.327,8,2,10]
["S3242","Loureirin B","f6","L9000-02","in 10mM DMSO","Calcium Channel,ERK,JNK,PAI-1,Potassium Channel","Metabolism","Loureirin B (LB, LrB), a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of PAI-1 with IC50 of 26.10 μM. Loureirin B downregulates p-ERK and p-JNK in TGF-β1-stimulated fibroblasts. Loureirin B promotes insulin secretion mainly through increasing Pdx-1, MafA, intracellular ATP level, inhibiting the KATP current, influx of Ca2+ to the intracellular.",316.35,"119425-90-0",{"v":100,"d":"100.00"},316.11,{"v":-1,"d":"-1.00"},"N/A","http://www.selleckchem.com/products/loureirin-b.html","C18H20O5","free base","LB, LrB","COC1=CC(=C(CCC(=O)C2=CC=C(O)C=C2)C(=C1)OC)OC",3.434,4,1,7]
["S6664","Gefapixant","g6","L9000-02","in 10mM DMSO","P2 Receptor","Neuronal Signaling","Gefapixant (AF-219, MK-7264, R1646, RG-1646, RO 4926219) is an orally active small molecule antagonist of human P2X3 receptor with IC50 of about 30 nM, 100–250 nM for recombinant hP2X3 homotrimers and hP2X2/3 heterotrimeric receptors, respectively. Gefapixant has shown promise for the treatment of refractory and unexplained chronic cough.",{"v":353.4,"d":"353.40"},"1015787-98-0",{"v":71,"d":"71.00"},200.91,"<1","N/A","http://www.selleckchem.com/products/gefapixant.html","C14H19N5O4S","free base","AF-219, MK-7264, R1646,RG-1646,RO 4926219","COC1=CC(=C(OC2=CN=C(N)N=C2N)C=C1[S](N)(=O)=O)C(C)C",1.061,6,3,5]
["S6847","ML-9 HCl","h6","L9000-02","in 10mM DMSO","Akt,Autophagy,Calcium Channel,MLCK","PI3K/Akt/mTOR","ML-9 HCl (ML-9 hydrochloride) is a selective and potent inhibitor of Akt kinase, myosin light chain kinase (MLCK) and stromal interaction molecule 1 (STIM1). ML-9 HCl is also a potent inhibitor of Ca2+-permeable channels. ML-9 HCl is a lysosomotropic agent targeting autophagy and cell death.",361.29,"105637-50-1",{"v":72,"d":"72.00"},199.29,{"v":10,"d":"10.00"},27.68,"http://www.selleckchem.com/products/ml-9-hcl.html","C15H18Cl2N2O2S","hydrochloride","ML-9 hydrochloride","Cl.ClC1=CC=CC2=C1C=CC=C2[S](=O)(=O)N3CCCNCC3",2.385,2,1,2]
["S6906","Capric acid","a7","L9000-02","in 10mM DMSO","GluR,PPAR","Neuronal Signaling","Capric acid (DA, Decanoic acid, Decylic acid), a component of medium-chain triclycerides occurring naturally in coconut oil and palm kernel oil, contributes to seizure control through direct AMPA receptor inhibition. Capric acid is also a modulating ligand for PPARs. Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.",172.26,"334-48-5",{"v":34,"d":"34.00"},197.38,{"v":34,"d":"34.00"},197.38,"http://www.selleckchem.com/products/capric-acid.html","C10H20O2","free base","DA, Decanoic acid, Decylic acid","CCCCCCCCCC(O)=O",3.655,1,0,8]
["S0000","Cav 2.2 blocker 1","b7","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Cav 2.2 blocker 1 (compound 9) is a N-type calcium channel (Cav 2.2) blocker for the treatment of pain with IC50 of 0.001 μM.",424.96,"1567335-29-8",{"v":12,"d":"12.00"},28.24,"<1","N/A","https://www.selleckchem.com/products/cav-2-2-blocker-1.html","C25H29ClN2O2","Free Base","compound 9","COC1=CC=CC=C1[N]2N=C(C=C2C3=CC=C(Cl)C=C3)C4CC(C)(C)OC(C)(C)C4",6.318,3,0,4]
["S0552","BNC210","c7","L9000-02","in 10mM DMSO","AChR","Neuronal Signaling","BNC210 (H-Ile-Trp-OH, IW-2143) is a negative allosteric modulator of alpha-7 nicotinic acetylcholine receptor (α7 nAChR).",317.38,"13589-06-5",{"v":63,"d":"63.00"},{"v":198.5,"d":"198.50"},"<1","N/A","https://www.selleckchem.com/products/bnc210.html","C17H23N3O3","Free Base","H-Ile-Trp-OH, IW-2143","CCC(C)C(N)C(=O)NC(CC1=C[NH]C2=CC=CC=C12)C(O)=O",-0.469,2,3,7]
["S0750","GFB-8438","d7","L9000-02","in 10mM DMSO","TRP Channel","Transmembrane Transporters","GFB-8438 is a novel, potent, and subtype selective TRP channel subfamily C (TRPC) inhibitor that is equipotent against TRPC4 and TRPC5 with IC50 of 0.18 μM and 0.29 μM, and shows excellent selectivity against TRPC6, other TRP family members , NaV 1.5, as well as limited activity against the hERG channel.",386.76,"2304549-73-1",{"v":77,"d":"77.00"},199.09,"<1","N/A","https://www.selleckchem.com/products/gfb-8438.html","C16H14ClF3N4O2","Free Base","N/A","FC(F)(F)C1=CC=CC=C1CN2CCN(CC2=O)C3=C(Cl)C(=O)NN=C3",1.445,3,1,4]
["S0826","A-740003","e7","L9000-02","in 10mM DMSO","Interleukins,P2 Receptor","Neuronal Signaling","A-740003 is a potent, selective and competitive antagonist of P2X7 receptor with IC50 of 18 nM and 40 nM for rat and human P2X7 receptors, respectively. A-740003 potently blocks agonist-evoked IL-1β release and pore formation with IC50 of 156 nM and 92 nM in differentiated human THP-1 cells.",474.55,"861393-28-4",{"v":95,"d":"95.00"},200.19,"<1","N/A","https://www.selleckchem.com/products/a-740003.html","C26H30N6O3","Free Base","N/A","COC1=C(OC)C=C(CC(=O)NC(NC(NC2=CC=CC3=C2C=CC=N3)=NC#N)C(C)(C)C)C=C1",3.849,5,3,10]
["S0870","Barnidipine","f7","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Barnidipine (Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca) is an antihypertensive drug that belongs to the dihydropyridine (DHP) group of calcium antagonist (CaA) with Ki of 0.21 nM for [3H]nitrendipine binding sites.",491.54,"104713-75-9",{"v":98,"d":"98.00"},199.37,"<1","N/A","https://www.selleckchem.com/products/barnidipine.html","C27H29N3O6","Free Base","Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca","COC(=O)C1=C(C)NC(=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OC3CCN(C3)CC4=CC=CC=C4)C",3.398,4,1,9]
["S0977","AC1903","g7","L9000-02","in 10mM DMSO","TRP Channel","Transmembrane Transporters","AC1903 (compound 2) is a specific and selective TRPC5 (transient receptor potential canonical channel 5) inhibitor with IC50 of 4.06 μM.",303.36,"831234-13-0",{"v":60,"d":"60.00"},197.78,"<1","N/A","https://www.selleckchem.com/products/ac1903.html","C19H17N3O","Free Base","N/A","C(NC1=NC2=CC=CC=C2[N]1CC3=CC=CC=C3)C4=CC=CO4",{"v":4.25,"d":"4.250"},2,1,5]
["S2953","Dooku1","h7","L9000-02","in 10mM DMSO","Mechanosensitive Channel","Transmembrane Transporters","Dooku1 is an analog of Yoda1 with antagonist activity against mechanosensitive Piezo1 channel. Dooku1 inhibits 2 μM Yoda1-induced Ca2+-entry with IC50 of 1.3 μM in HEK 293 cells and 1.5 μM in HUVECs, respectively.",{"v":326.2,"d":"326.20"},"2253744-54-4",{"v":65,"d":"65.00"},199.26,"<1","N/A","https://www.selleckchem.com/products/dooku1.html","C13H9Cl2N3OS","Free Base","N/A","ClC1=C(CSC2=NN=C(O2)C3=CC=C[NH]3)C(=CC=C1)Cl",{"v":4.51,"d":"4.510"},3,1,4]
["S6934","AMG-9810","a8","L9000-02","in 10mM DMSO","TLR,TRP Channel","Transmembrane Transporters","AMG-9810 is a potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.",337.41,"545395-94-6",{"v":67,"d":"67.00"},198.57,"<1","N/A","https://www.selleckchem.com/products/amg-9810.html","C21H23NO3","Free Base","N/A","CC(C)(C)C1=CC=C(/C=C/C(=O)NC2=CC=C3OCCOC3=C2)C=C1",4.268,3,1,4]
["S9686","NBQX (FG9202)","b8","L9000-02","in 10mM DMSO","GluR","Neuronal Signaling","NBQX (FG9202, NNC 079202) is a highly selective and competitive antagonist of AMPA receptor (AMPAR) with anti-epileptic effect.",336.28,"118876-58-7",{"v":67,"d":"67.00"},199.24,"<1","N/A","https://www.selleckchem.com/products/nbqx.html","C12H8N4O6S","Free Base","NNC 079202","N[S](=O)(=O)C1=C2C(=CC=C1)C3=C(NC(=O)C(=O)N3)C=C2[N+]([O-])=O",-0.441,4,3,2]
["S5898","Efonidipine hydrochloride monoethanolate","c8","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Efonidipine (NZ-105) hydrochloride monoethanolate is an L- and T-type calcium channel blocker leading to vasodilation and decreased automaticity of the heart. Efonidipine hydrochloride monoethanolate also suppresses aldosterone secretion from the adrenal.",714.18,"111011-76-8",{"v":100,"d":"100.00"},140.02,"<1","N/A","http://www.selleckchem.com/products/efonidipine-hydrochloride-monoethanolate.html","C36H45ClN3O8P","Hydrochloride monoethanolate","NZ-105 hydrochloride monoethanolate","Cl.CCO.CC1=C(C(C2=CC(=CC=C2)[N+]([O-])=O)C(=C(C)N1)[P]3(=O)OCC(C)(C)CO3)C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5",5.329,4,2,11]
["S5966","Amlodipine maleate","d8","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Amlodipine (Amvaz, UK-48340) maleate is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.",524.95,"88150-47-4",{"v":100,"d":"100.00"},190.49,"<1","N/A","http://www.selleckchem.com/products/amlodipine-maleate.html","C24H29ClN2O9","Maleate","Amvaz, UK-48340 maleate","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C.OC(=O)\\C=C/C(O)=O",-0.864,7,2,12]
["S0446","TCN 201","e8","L9000-02","in 10mM DMSO","NMDAR","Neuronal Signaling","TCN-201 is  a selective GluN1/GluN2A (NR1/NR2A) NMDA receptor antagonist with pIC50 6.8 for NR1/NR2A and <4.3 for NR1/NR2B (GluN1/GluN2B),respectively.",461.89,"852918-02-6",{"v":92,"d":"92.00"},199.18,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/tcn-201.html","C21H17ClFN3O4S","Free Base","N/A","FC1=C(Cl)C=C(C=C1)[S](=O)(=O)NCC2=CC=C(C=C2)C(=O)NNC(=O)C3=CC=CC=C3",3.236,4,3,7]
["E0028","9-Phenanthrol","f8","L9000-02","in 10mM DMSO","TRP Channel","Transmembrane Transporters","9-Phenanthrol (9-Hydroxyphenanthrene, Phenanthren-9-o, 9-Phenanthrenol) is a selective TRPM4 inhibitor with an IC50 in the range of 0.02 μM, without effects on TRPM5.",194.23,"484-17-3",{"v":39,"d":"39.00"},200.79,"<1",{"v":0,"d":"0.00"},"http://www.selleckchem.com/products/9-phenanthrol.html","C14H10O","Free Base","9-Hydroxyphenanthrene, Phenanthren-9-ol, 9-Phenanthrenol","OC1=CC2=CC=CC=C2C3=CC=CC=C13",3.404,0,1,0]
["S6070","CBA (TRPM4-IN-5)","g8","L9000-02","in 10mM DMSO","TRP Channel","Transmembrane Transporters","CBA (TRPM4-IN-5, Compound 5) is a highly selective blocker of the TRPM4 ion channel with an IC50 of 1.5μM.",340.16,"351424-20-9",{"v":68,"d":"68.00"},199.91,"<1","N/A","http://www.selleckchem.com/products/cba-trpm4-in-1.html","C15H11Cl2NO4","Free Base","Compound 5, TRPM4 inhibitor 5","OC(=O)C1=C(NC(=O)COC2=CC=CC=C2Cl)C=C(Cl)C=C1",{"v":3.41,"d":"3.410"},3,1,5]
["S9498","5-BDBD","h8","L9000-02","in 10mM DMSO","P2 Receptor","Neuronal Signaling","5-BDBD is a potent P2X4R selective antagonist with an IC50 of 0.75 μM when applied for 2 min prior and during ATP stimulation.",355.19,"768404-03-1",{"v":71,"d":"71.00"},199.89,"<1","N/A","http://www.selleckchem.com/products/5-bdbd.html","C17H11BrN2O2","Free Base","N/A","BrC1=CC=CC(=C1)C2=NCC(=O)NC3=C2OC4=CC=CC=C34",{"v":3.64,"d":"3.640"},3,1,1]
["E0026","ML-SI3","a9","L9000-02","in 10mM DMSO","TRP Channel","Transmembrane Transporters","ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 &micro;M and 1.7 &micro;M for TRPML1 and TRPML2, respectively.",429.58,"891016-02-7",{"v":43,"d":"43.00"},{"v":100.1,"d":"100.10"},"<1","N/A","http://www.selleckchem.com/products/ml-si3.html","C23H31N3O3S","Free Base","N/A","COC1=CC=CC=C1N2CCN(CC2)C3CCCCC3N[S](=O)(=O)C4=CC=CC=C4",{"v":3.92,"d":"3.920"},3,1,6]
["S0452","NP118809","b9","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","NP118809(39-1B4) is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM, also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM.",460.61,"41332-24-5",{"v":92,"d":"92.00"},199.74,"<1","N/A","http://www.selleckchem.com/products/np118809.html","C32H32N2O","free base","39-1B4","O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)N3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5",6.172,1,0,7]
["S0518","NS 1738","c9","L9000-02","in 10mM DMSO","AChR","GPCR & G Protein","NS 1738 (NSC 213859) is a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor (α7 nAChR), with respect to positive modulation of Xenopus laevis oocyte α7 nAChR with EC50 of 3.4 μM, as well as a comparable efficacy at the rat α7 nAChR with EC50 of 3.9 μM.",365.13,"501684-93-1",{"v":73,"d":"73.00"},199.93,"<1","N/A","http://www.selleckchem.com/products/ns-1738.html","C14H9Cl2F3N2O2","free base","NSC 213859","OC1=CC=C(Cl)C=C1NC(=O)NC2=CC(=CC=C2Cl)C(F)(F)F",4.552,1,3,3]
["S0521","PNU-282987 S enantiomer free base","d9","L9000-02","in 10mM DMSO","AChR","Neuronal Signaling","PNU-282987 S enantiomer free base is the S-enantiomer of PNU-282987 free base, which is an α7 nicotinic acetylcholine receptor (α7 nAChR) agonist.",264.75,"737727-12-7",{"v":53,"d":"53.00"},200.19,"<1","N/A","http://www.selleckchem.com/products/pnu-282987-s-enantiomer-free-base.html","C14H17ClN2O","free base","N/A","ClC1=CC=C(C=C1)C(=O)NC2CN3CCC2CC3",2.238,1,1,2]
["S2957","Encenicline (EVP-6124) hydrochloride","e9","L9000-02","in 10mM DMSO","AChR","Neuronal Signaling","Encenicline (EVP-6124) hydrochloride is a selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.",{"v":357.3,"d":"357.30"},"550999-74-1",{"v":71,"d":"71.00"},198.71,"<1","N/A","http://www.selleckchem.com/products/encenicline-hydrochloride.html","C16H17ClN2OS.ClH","hydrochloride","N/A","Cl.ClC1=C2SC(=CC2=CC=C1)C(=O)NC3CN4CCC3CC4",3.773,1,1,2]
["S3535","Deudextromethorphan (AVP-786)","f9","L9000-02","in 10mM DMSO","NMDAR","Neuronal Signaling","Deudextromethorphan (AVP-786) is an active N-methyl-D-aspartate (NMDA) receptor antagonist.",277.43,"1079043-55-2",{"v":55,"d":"55.00"},198.25,{"v":14,"d":"14.00"},50.46,"http://www.selleckchem.com/products/deudextromethorphan-avp-786.html","C18H19D6NO","free base","N/A","C(OC1=CC=C2CC3C4CCCCC4(CCN3C([2H])([2H])[2H])C2=C1)([2H])([2H])[2H]",3.674,1,0,3]
["E0379","SEN12333","g9","L9000-02","in 10mM DMSO","AChR,Calcium Channel","Neuronal Signaling","SEN12333(WAY-317538), a novel selective agonist of alpha7 nicotinic acetylcholine receptor (nAChR), shows high affinity for the rat nAChR expressed in GH4C1 cells with Ki of 260 nM, and acts as full agonist in functional Ca2+ flux studies with EC50 of 1.6 μM.",339.43,"874450-44-9",{"v":68,"d":"68.00"},200.34,"<1","N/A","http://www.selleckchem.com/products/sen12333.html","C20H25N3O2","free base","WAY-317538","O=C(CCCCN1CCOCC1)NC2=CC=C(C=C2)C3=CC=CN=C3",2.037,3,1,7]
["E0484","CNQX","h9","L9000-02","in 10mM DMSO","GluR","Neuronal Signaling","CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) is an AMPA and kainate receptor antagonist with IC50 values are 0.3 μM and 1.5 μM for AMPA and kainate receptors, respectively. CNQX is also an antagonist at the glycine modulatory site on the NMDA receptor complex (IC50 = 25 μM). CNQX shows neuroprotective effects in models of ischemia and inhibits seizure-like activity in hippocampal neurons.",232.15,"115066-14-3",{"v":46,"d":"46.00"},198.15,"<1","N/A","http://www.selleckchem.com/products/cnqx.html","C9H4N4O4","free base","6-cyano-7-nitroquinoxaline-2,3-dione","[O-][N+](=O)C1=CC2=C(NC(=O)C(=O)N2)C=C1C#N",-0.176,2,2,1]
["E0777","Z944","a10","L9000-02","in 10mM DMSO","Calcium Channel","Neuronal Signaling","Z944 is a highly selective antagonist for T-type calcium channel with IC50s of 50, 160, 110 nM for hCaV3.1, hCaV3.2, and hCaV3.3.",383.89,"1199236-64-0",{"v":19,"d":"19.00"},49.49,"<1","N/A","http://www.selleckchem.com/products/z944.html","C19H27ClFN3O2","free base","N/A","CC(C)(C)NC(=O)CN1CCC(CC1)CNC(=O)C2=CC(=CC(=C2)Cl)F",2.587,2,2,6]
["E0826","Levamlodipine Besylate","b10","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Levamlodipine Besylate is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina.",448.88,"150566-71-5",{"v":100,"d":"100.00"},222.78,{"v":2,"d":"2.00"},4.46,"http://www.selleckchem.com/products/levamlodipine-besylate.html","C20H25ClN2O5.C6H6O3S","Besylate","N/A","CCOC(=O)C1=C(COCCN)NC(=C(C1C2=C(Cl)C=CC=C2)C(=O)OC)C.O[S](=O)(=O)C3=CC=CC=C3",3.473,5,2,11]
["E1050","PEAQX","c10","L9000-02","in 10mM DMSO","NMDAR","Neuronal Signaling","PEAQX (NVP-AAM077) is an effective and orally available human NMDA antagonist, which shows preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over hNMDA 1A/2B receptors (IC50=29,600 nM).",454.21,"459836-30-7",{"v":91,"d":"91.00"},200.35,"<1","N/A","http://www.selleckchem.com/products/peaqx.html","C17H17BrN3O5P","free base","NVP-AAM077","CC(NC(C1=C2NC(=O)C(=O)NC2=CC=C1)[P;v5](O)(O)=O)C3=CC=C(Br)C=C3",1.733,2,3,5]
["E2684","Icilin","d10","L9000-02","in 10mM DMSO","TRP Channel","Neuronal Signaling","Icilin is an agonist of the transient receptor potential M8 (TRPM8) ion channel with an EC50 of 1.4 μM.",311.29,"36945-98-9",{"v":62,"d":"62.00"},199.17,"<1","N/A","http://www.selleckchem.com/products/icilin.html","C16H13N3O4","free base","N/A","OC1=C(C=CC=C1)N2CC=C(NC2=O)C3=CC(=CC=C3)[N;v5](=O)=O",2.306,1,2,3]
["S0702","α-Conotoxin GI","e10","L9000-02","in 10mM DMSO","AChR","Neuronal Signaling","α-Conotoxin GI, a 13-residue peptide originally isolated from the venom of the fish-hunting cone snail Conus geographus, acts as a competitive antagonist for the muscle-type nicotinic acetylcholine receptor (nAChR) with excellent selectivity for α/δ receptor subunit binding over α/γ.",1437.61,"76862-65-2",{"v":100,"d":"100.00"},69.56,{"v":50,"d":"50.00"},34.78,"http://www.selleckchem.com/products/alpha-conotoxin-gi.html","C55H80N20O18S4","Free base","N/A","CC1NC(=O)C2CCCN2C(=O)C(CC(N)=O)NC(=O)C3CSSCC(NC(=O)C(CO)NC(=O)C(CC4=CC=C(O)C=C4)NC(=O)C(CC5=CN=C[NH]5)NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(CSSCC(NC(=O)C(N)CCC(O)=O)C(=O)N3)NC1=O)C(N)=O",-11.116,16,19,18]
["S2975","CarboxyaMidotriazole orotate","f10","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate inhibits angiogenesis, tumor growth, invasion, and metastasis.",580.76,"187739-60-2",{"v":25,"d":"25.00"},43.05,"<1","N/A","http://www.selleckchem.com/products/carboxyamidotriazole-orotate.html","C22H16Cl3N7O6","Orotate","L-651582 Orotate, CAI Orotate","NC(=O)C1=C(N)[N](CC2=CC(=C(C(=C2)Cl)C(=O)C3=CC=C(Cl)C=C3)Cl)N=N1.OC(=O)C4=CC(=O)NC(=O)N4",{"v":2.65,"d":"2.650"},7,4,6]
["S3520","AZ10606120 dihydrochloride","g10","L9000-02","in 10mM DMSO","P2 Receptor","Neuronal Signaling","AZ10606120 dihydrochloride (2HCl) is a potent and selective antagonist for P2X7 receptor (P2X7R) with IC50 of ~10 nM. AZ10606120 dihydrochloride exhibits anti-depressant effects and reduces tumour growth.",495.48,"607378-18-7",{"v":99,"d":"99.00"},199.81,{"v":17,"d":"17.00"},34.31,"http://www.selleckchem.com/products/az10606120-dihydrochloride.html","C25H36Cl2N4O2","Dihydrochloride","AZ10606120 2HCl","Cl.Cl.OCCNCCNC1=NC2=C(C=C1)C(=CC=C2)NC(=O)CC34CC5CC(CC(C5)C3)C4",3.902,2,4,9]
["S6731","Eliprodil (SL-820715)","h10","L9000-02","in 10mM DMSO","NMDAR","Neuronal Signaling","Eliprodil (SL-820715) is a non-competitive NR2B-selective NMDA antagonist with IC50 value of 1 μM and is less potent for NR2A- and NR2C-containing receptors with IC50 > 100 μM.",347.85,"119431-25-3",{"v":15,"d":"15.00"},43.12,"<1","N/A","http://www.selleckchem.com/products/eliprodil.html","C20H23ClFNO","Free base","N/A","OC(CN1CCC(CC1)CC2=CC=C(F)C=C2)C3=CC=C(Cl)C=C3",{"v":4.92,"d":"4.920"},0,1,5]
["S8513","JNJ-47965567","a11","L9000-02","in 10mM DMSO","P2 Receptor","Transmembrane Transporters","JNJ-47965567 is a centrally permeable, high-affinity, selective P2X7 antagonist, which can be used to probe the role of central P2X7 in rodent models of CNS pathophysiology.",488.65,"1428327-31-4",{"v":98,"d":"98.00"},200.55,"<1","N/A","https://www.selleckchem.com/products/jnj-47965567.html","C28H32N4O2S","Free base","N/A","O=C(NCC1(CCOCC1)N2CCN(CC2)C3=CC=CC=C3)C4=C(SC5=CC=CC=C5)N=CC=C4",{"v":4.01,"d":"4.010"},3,1,7]
["E0357","Eliapixant","b11","L9000-02","in 10mM DMSO","P2 Receptor","Neuronal Signaling","Eliapixant (BAY1817080) is a highly potent and selective P2X3 receptor antagonist with a mean IC50 of 8 nM.",478.49,"1948229-21-7",{"v":96,"d":"96.00"},200.63,"<1","N/A","http://www.selleckchem.com/products/eliapixant.html","C22H21F3N4O3S","Free base","BAY 1817080","CC(NC(=O)C1=CC(=CC(=C1)OC2CCOC2)C3=NC=C(C)S3)C4=CN=C(N=C4)C(F)(F)F",2.552,6,1,7]
["E1259","DNQX","c11","L9000-02","in 10mM DMSO","Calcium Channel,GluR","Neuronal Signaling","DNQX is an AMPA receptor antagonist that prevents excess calcium influx via voltage-gated calcium channels.",252.14,"2379-57-9",{"v":50,"d":"50.00"},{"v":198.3,"d":"198.30"},"<1","N/A","https://www.selleckchem.com/products/dnqx.html","C8H4N4O6","Free base","FG 9041","O=C1NC2=CC(=C(C=C2NC1=O)[N;v5](=O)=O)[N;v5](=O)=O",-0.161,2,2,2]
["E1368","PD173212","d11","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","PD173212(Compound 11) is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays.",599.85,"217171-01-2",{"v":100,"d":"100.00"},166.71,"<1","N/A","https://www.selleckchem.com/products/pd173212.html","C38H53N3O3","free base","Compound 11","CC(C)CC(N(C)CC1=CC=C(C=C1)C(C)(C)C)C(=O)NC(CC2=CC=C(OCC3=CC=CC=C3)C=C2)C(=O)NC(C)(C)C",7.678,3,2,15]
["E1410","Fluspirilene","e11","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Fluspirilene(R 6218; Redeptin) is a non-competitive antagonist of L-type calcium channels with an IC50 of 0.03 μM in cell-free assays. Fluspirileneis a long-acting injectable depot antipsychotic agent used for schizophrenia.",475.57,"1841-19-6",{"v":95,"d":"95.00"},199.76,"<1","N/A","https://www.selleckchem.com/products/fluspirilene.html","C29H31F2N3O","free base","R 6218, Redeptin","FC1=CC=C(C=C1)C(CCCN2CCC3(CC2)N(CNC3=O)C4=CC=CC=C4)C5=CC=C(F)C=C5",5.545,1,1,7]
["E2984","GSK-7975A","f11","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","GSK-7975A is a potent and orally available inhibitor of CRAC channel. It reduces FcεRI-dependent Ca2+ influx and reduces the release of histamine, leukotriene C4, and cytokines (IL-5/-8/-13 and TNFα).",{"v":397.3,"d":"397.30"},"1253186-56-9",{"v":79,"d":"79.00"},198.84,"<1","N/A","https://www.selleckchem.com/products/gsk-7975a.html","C18H12F5N3O2","free base","N/A","OC1=CC(=C(C[N]2C=CC(=N2)NC(=O)C3=C(F)C=CC=C3F)C=C1)C(F)(F)F",4.498,2,2,5]
["E2993","Ruthenium Red","g11","L9000-02","in 10mM DMSO","Calcium Channel","Transmembrane Transporters","Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye, which is a L-type calcium current  (ICa) blocker. It is  widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides.",786.35,"11103-72-3",{"v":100,"d":"100.00"},127.17,{"v":100,"d":"100.00"},127.17,"https://www.selleckchem.com/products/ruthenium-red.html","N/A","oxychloride","Ammoniated ruthenium oxychloride","N/A","N/A","N/A","N/A","N/A"]
["S1338","Gabapentin HCl","a2","L9000-03","in 10mM Water","GABA Receptor","Neuronal Signaling","Gabapentin HCl(Neurontin HCl) is a GABA analogue, used to treat seizures and neuropathic pain.",{"v":207.7,"d":"207.70"},"60142-95-2","<1","N/A",{"v":42,"d":"42.00"},202.21,"http://selleckchem.com/products/Gabapentin.html","C9H17NO2.HCl","Hydrochloride","Neurontin HCl","Cl.NCC1(CCCCC1)CC(O)=O",-1.104,1,1,3]
["S2133","Gabapentin","b2","L9000-03","in 10mM Water","GABA Receptor","Neuronal Signaling","Gabapentin is a GABA analogue, used to treat seizures and neuropathic pain.",171.24,"60142-96-3","<1","N/A",{"v":34,"d":"34.00"},198.55,"http://selleckchem.com/products/Gabapentin(Neurontin).html","C9H17NO2","Free Base","N/A","NCC1(CCCCC1)CC(O)=O",-1.486,1,1,3]
["S2568","Neomycin sulfate","c2","L9000-03","in 10mM Water","Antibiotics,Antibiotics for Mammalian Cell Culture,Antineoplastic and Immunosuppressive Antibiotics,Bacterial,Selection Antibiotics for Transfected Cell","Microbiology","Neomycin sulfate(Framycin sulfate) is an aminoglycoside antibiotic, used to treat bacteria infections.",712.72,"28002-70-2 ,1405-10-3","<1","N/A",{"v":143,"d":"143.00"},200.64,"http://selleckchem.com/products/Neomycin-sulfate.html","C23H46N6O13.H2SO4","Sulfate","Framycin sulfate","NCC1OC(OC2C(N)CC(N)C(O)C2OC3OC(CO)C(OC4OC(CN)C(O)C(O)C4N)C3O)C(N)C(O)C1O.O[S](O)(=O)=O",-9.566,6,13,9]
["S5022","Varenicline Hydrochloride","d2","L9000-03","in 10mM Water","AChR","Neuronal Signaling","Varenicline (CP 526555) Hydrochloride is a potent and selective inhibitor of nicotine acetylcholine receptor (nAChR) with Ki of 0.12 nM and 0.14 nM for α6β2 nAChR and α4β2 nAChR, respectively.",247.72,"230615-23-3","<1","N/A",{"v":50,"d":"50.00"},201.84,"http://www.selleckchem.com/products/varenicline-hydrochloride.html","C13H14ClN3","Hydrochloride","CP 526555 hydrochloride","Cl.C1NCC2CC1C3=CC4=NC=CN=C4C=C23",{"v":1.42,"d":"1.420"},2,1,0]
["E1246","D-AP5","e2","L9000-03","in 10mM Water","NMDAR","Neuronal Signaling","D-AP5 (D-APV; D-2-Amino-5-phosphonovaleric acid) is a selective and competitive NMDA receptor antagonist that inhibits the glutamate binding site of NMDA receptors.",197.13,"79055-68-8","<1","N/A",{"v":39,"d":"39.00"},197.84,"https://www.selleckchem.com/products/d-ap5.html","C5H12NO5P","Free base","N/A","NC(CCC[P](O)(O)=O)C(O)=O",-3.632,1,1,5]
["E2979","DL-AP5 (2-APV)","f2","L9000-03","in 10mM Water","NMDAR","Neuronal Signaling","DL-AP5 (2-APV, DL-2-Amino-5-phosphonovaleric acid) is a competitive antagonist of NMDA (N-methyl-D-aspartate) receptor. It shows significantly antinociceptive activity and specifically blocks on channels in the rabbit retina.",197.13,"76326-31-3","<1","N/A",{"v":39,"d":"39.00"},197.84,"https://www.selleckchem.com/products/dl-ap5-2-apv.html","C5H12NO5P","Free base","DL-2-Amino-5-phosphonovaleric acid","NC(CCC[P](O)(O)=O)C(O)=O",-3.632,1,1,5]
["S2251","(-)-Huperzine A (HupA)","a2","L9000-04","in 2mM DMSO","AChR,GluR","Neuronal Signaling","(-)-Huperzine A is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE) with Ki of 7 nM, exhibiting 200-fold more selectivity for G4 AChE over G1 AChE. Also acts as an NMDA receptor antagonist. Phase 4.",242.32,"102518-79-6",0.66,2.72,"<1","N/A","http://selleckchem.com/products/(-)-Huperzine-A.html","C15H18N2O","Free Base","N/A","C\\C=C/1C2CC3=C(C=CC(=O)N3)C1(N)CC(=C2)C",1.056,1,2,0]
["S4156","Chlortetracycline HCl (NSC 13252)","b2","L9000-04","in 2mM DMSO","Antibiotics,Antineoplastic and Immunosuppressive Antibiotics","Microbiology","Chlortetracycline HCl (NSC 13252, 7-Chlorotetracycline, Aureomycin monohydrochloride) is the first identified tetracycline antibiotic.",515.34,"64-72-2",{"v":5,"d":"5.00"},{"v":9.7,"d":"9.70"},{"v":1,"d":"1.00"},1.94,"http://selleckchem.com/products/chlortetracycline-hcl.html","C22H23ClN2O8.HCl","Hydrochloride","7-Chlorotetracycline HCl, Aureomycin monohydrochloride","Cl.CN(C)C1C2CC3C(=C(O)C2(O)C(=O)C(=C1O)C(N)=O)C(=O)C4=C(C(=CC=C4O)Cl)C3(C)O",{"v":0,"d":"0.000"},0,0,0]
["S6632","Mirogabalin (DS-5565)","c2","L9000-04","in 2mM DMSO","Others","Others","Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand that has been used in trials studying the treatment of Post-herpetic Neuralgia, Pain Associated With Fibromyalgia, and Diabetic peripheral neuropathic pain.",209.28,"1138245-13-2",{"v":2,"d":"2.00"},9.56,{"v":3,"d":"3.00"},14.33,"http://www.selleck.cn/products/mirogabalin-ds-5565.html","C12H19NO2","Free Base","N/A","CCC1=CC2C(C1)CC2(CN)CC(O)=O",-1.352,1,1,4]
["E0524","Spinosad","d2","L9000-04","in 2mM DMSO","AChR,Anti-infection","Neuronal Signaling","Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete, is a biological neurotoxic insecticide with a broader action spectrum, targeting the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system.",731.96,"168316-95-8",{"v":3,"d":"3.00"},{"v":4.1,"d":"4.10"},"<1","N/A","http://www.selleckchem.com/products/spinosad.html","C41H65NO10","free base","N/A","NA","NA","NA","NA","NA"]
["S1911","Disodium Cromoglycate","a2","L9000-05","in 2mM Water","Calcium Channel","Transmembrane Transporters","Disodium Cromoglycate (Gynazole ,FPL 670 (Cromolyn) Disodium,Cromolyn sodium) is an antiallergic drug with IC50 of 39 μg/mL.",512.33,"15826-37-6","<1","N/A",{"v":2,"d":"2.00"},{"v":3.9,"d":"3.90"},"http://selleckchem.com/products/disodium-Cromoglycate.html","C23H14O11.2Na","Disodium Salt","Gynazole ,FPL 670 (Cromolyn) Disodium,Cromolyn sodium","[Na+].[Na+].OC(COC1=C2C(=O)C=C(OC2=CC=C1)C([O-])=O)COC3=CC=CC4=C3C(=O)C=C(O4)C([O-])=O",-1.178,6,1,8]