JAK ATM ATR ATM Chk1 TLK1/2 H2AX BRCA1 c-Abl p53 Chk2 PARP CDK Wee1 Topoisomerase CDC25 Aurora Kinase PLK DNA-PK Double-strand Breaks Alkylating Agents Replication Stress Apoptosis DNA Repair Cell Cycle ChromatinRemodeling Mdm2 DNA-PK InhibitorsNU7441NU7026CC-115KU-0060648 p53 ActivatorsAPR-246CBL0137p53 InhibitorsPifithrin-αPifithrin-μ Pan-PARP InhibitorsOlaparibTalazoparibRucaparibVeliparibNiraparibSelective PARP InhibitorAG-14361 (PARP-1) Dual ATM/ATR InhibitorsKU-55933BerzosertibSelective ATM/ATR InhibitorsAZD6738 (ATR)VE-821 (ATR)KU-60019 (ATM) Pan-Topoisomerase InhibitorEpirubicinSelective Topoisomerase InhibitorsDoxorubicin (TOPO II)Etoposide (TOPO II)Irinotecan (TOPO I)SN-38 (TOPO I)Camptothecin (TOPO I) Pan-Chk InhibitorAZD7762Selective Chk InhibitorsPrexasertib (Chk1)Rabusertib (Chk1)MK-8776 (Chk1)CHIR-124 (Chk1) P {{ board.text }} Double-strand Breaks Replication Stress Alkylating Agents DNA Repair Chromatin Remodeling {{ board.text }} {{ board.text }} {{ board.text }} {{ board.text }} {{ group.title }} {{ text.text }} {{ button.text }} {{ group.title }} {{ text.text }} Notes: 1:Clickable 2:Unclickable