JAK
ATM
ATR
ATM
Chk1
TLK1/2
H2AX
BRCA1
c-Abl
p53
Chk2
PARP
CDK
Wee1
Topoisomerase
CDC25
Aurora Kinase
PLK
DNA-PK
Double-strand Breaks
Alkylating Agents
Replication Stress
Apoptosis
DNA Repair
Cell Cycle
ChromatinRemodeling
Mdm2
DNA-PK InhibitorsNU7441NU7026CC-115KU-0060648
p53 ActivatorsAPR-246CBL0137p53 InhibitorsPifithrin-αPifithrin-μ
Pan-PARP InhibitorsOlaparibTalazoparibRucaparibVeliparibNiraparibSelective PARP InhibitorAG-14361 (PARP-1)
Dual ATM/ATR InhibitorsKU-55933BerzosertibSelective ATM/ATR InhibitorsAZD6738 (ATR)VE-821 (ATR)KU-60019 (ATM)
Pan-Topoisomerase InhibitorEpirubicinSelective Topoisomerase InhibitorsDoxorubicin (TOPO II)Etoposide (TOPO II)Irinotecan (TOPO I)SN-38 (TOPO I)Camptothecin (TOPO I)
Pan-Chk InhibitorAZD7762Selective Chk InhibitorsPrexasertib (Chk1)Rabusertib (Chk1)MK-8776 (Chk1)CHIR-124 (Chk1)
P
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Double-strand Breaks
Replication Stress
Alkylating Agents
DNA Repair
Chromatin
Remodeling
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Notes:
1:Clickable
2:Unclickable