=
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
=
P
P
S
C
Ub
O
=
S
C
Ub
O
=
S
C
Ub
O
=
P
RING-type
AMP+PPi
ADP+Pi
Proteasome
Proteasome
Proteasome
Proteasome
Proteasome
Proteasome Inhibition
Proteasome Inhibition
Proteasome Inhibition
CDC25C
CDK–cyclin B
CDK–cyclin A
CDK–cyclin D
CDK–cyclin E
CDC25A, CDC25C
KIP1
Apoptosis
G0
M
G2
G1
S
WAF1
CDC25B
CDK–cyclin A
ATP
ATP
N
H
C
O
S
26S Proteasome
RP
C
O
HECT-type
Cellular Pathways Associated with the Proteasome
HECT
RING Finger
Gene
Expression
Gene
Expression
Pro-survival
Pathway
Senescence
E1
DUBs
DUBs
DUBs
DUBs
NF-κB
Mdm2
p53
p53
p53
IκB
NF-κB
IκB
IκB
NF-κB
IκB Kinase
E2
E3
E3
E2
Cellular Stress
ARF
Stress
Apoptosis
S
S
S
E1 Activating Inhibitors
Pevonedistat
PYR-41
TAK-243
DUB Inhibitors
PR-619
P5091
P22077
IU1
ML323
DUB Inhibitors
PR-619
P5091
P22077
IU1
ML323
Pan-Proteasome Inhibitors
Carfilzomib
Epoxomicin
Selective Proteasome Inhibitors
MG-132 (26S Proteasome)
Bortezomib (20S Proteasome)
Ixazomib (20S Proteasome)
Celastrol (20S Proteasome)
E2 Conjugating Inhibitors
BAY 11-7082
NSC697923
Mdm2 Inhibitors
Nutlin-3
Nutlin-3a
Idasanutlin
HDM201
p53 Activators
APR-246
CBL0137
p53 Inhibitors
Pifithrin-α
Pifithrin-μ
E3 Ligase Activator
(-)-Parthenolide
E3 Ligase Antagonists
Thalidomide
JNJ-26854165
Nutlin-3
E3 Ligase Modulator
Avadomide
Pan-IκB/IKK Inhibitors
Bardoxolone Methyl
IKK-16
Selective IκB/IKK Inhibitors
MRT67307 (IKKϵ)
IMD 0354 (IKKβ)
TPCA-1 (IKK-2)
NF-κB Inhibitors
BAY 11-7082
JSH-23
QNZ
SC75741
Pyrrolidinedithiocarbamate
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RING-type
RING Finger
HECT-type
HECT
26S Proteasome
ATP
ATP
AMP+PPi
ADP+Pi
Cellular Pathways Associated with the Proteasome
Cellular Stress
Stress
WAF1
CDC25C
CDC25B
CDK-cyclin A
CDK-cyclin B
CDK-cyclin A
CDK-cyclin D
CDK-cyclin E
Proteasome Inhibition
Proteasome Inhibition
Proteasome Inhibition
G0
G1
G2
S
M
Senescence
O
O
C
C
S
S
N
H
RP
CDC25A, CDC25C
KIP1
Pro-survival
Pathway
Gene
Expression
Gene
Expression
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Notes:
1:Clickable
2:Unclickable