= Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub Ub = P P S C Ub O = S C Ub O = S C Ub O = P RING-type AMP+PPi ADP+Pi Proteasome Proteasome Proteasome Proteasome Proteasome Proteasome Inhibition Proteasome Inhibition Proteasome Inhibition CDC25C CDK–cyclin B CDK–cyclin A CDK–cyclin D CDK–cyclin E CDC25A, CDC25CKIP1 Apoptosis G0 M G2 G1 S WAF1 CDC25B CDK–cyclin A ATP ATP N H C O S 26S Proteasome RP C O HECT-type Cellular Pathways Associated with the Proteasome HECT RING Finger GeneExpression GeneExpression Pro-survivalPathway Senescence E1 DUBs DUBs DUBs DUBs NF-κB Mdm2 p53 p53 p53 IκB NF-κB IκB IκB NF-κB IκB Kinase E2 E3 E3 E2 Cellular Stress ARF Stress Apoptosis S S S E1 Activating InhibitorsPevonedistatPYR-41TAK-243 DUB InhibitorsPR-619P5091P22077IU1ML323 DUB InhibitorsPR-619P5091P22077IU1ML323 Pan-Proteasome InhibitorsCarfilzomibEpoxomicinSelective Proteasome InhibitorsMG-132 (26S Proteasome)Bortezomib (20S Proteasome)Ixazomib (20S Proteasome)Celastrol (20S Proteasome) E2 Conjugating InhibitorsBAY 11-7082NSC697923 Mdm2 InhibitorsNutlin-3Nutlin-3aIdasanutlinHDM201 p53 ActivatorsAPR-246CBL0137p53 InhibitorsPifithrin-αPifithrin-μ E3 Ligase Activator(-)-ParthenolideE3 Ligase AntagonistsThalidomideJNJ-26854165Nutlin-3E3 Ligase ModulatorAvadomide Pan-IκB/IKK InhibitorsBardoxolone MethylIKK-16Selective IκB/IKK InhibitorsMRT67307 (IKKϵ)IMD 0354 (IKKβ)TPCA-1 (IKK-2) NF-κB InhibitorsBAY 11-7082JSH-23QNZSC75741Pyrrolidinedithiocarbamate {{ board.text }} RING-type RING Finger HECT-type HECT 26S Proteasome ATP ATP AMP+PPi ADP+Pi Cellular Pathways Associated with the Proteasome Cellular Stress Stress WAF1 CDC25C CDC25B CDK-cyclin A CDK-cyclin B CDK-cyclin A CDK-cyclin D CDK-cyclin E Proteasome Inhibition Proteasome Inhibition Proteasome Inhibition G0 G1 G2 S M Senescence O O C C S S N H RP CDC25A, CDC25C KIP1 Pro-survival Pathway Gene Expression Gene Expression {{ board.text }} {{ board.text }} {{ board.text }} {{ board.text }} {{ board.text }} {{ board.text }} {{ group.title }} {{ text.text }} {{ button.text }} {{ group.title }} {{ text.text }} Notes: 1:Clickable 2:Unclickable