=
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
Ub
=
P
P
S
C
Ub
O
=
S
C
Ub
O
=
S
C
Ub
O
=
P
RING-type
AMP+PPi
ADP+Pi
Proteasome
Proteasome
Proteasome
Proteasome
Proteasome
Proteasome Inhibition
Proteasome Inhibition
Proteasome Inhibition
CDC25C
CDK–cyclin B
CDK–cyclin A
CDK–cyclin D
CDK–cyclin E
CDC25A, CDC25CKIP1
Apoptosis
G0
M
G2
G1
S
WAF1
CDC25B
CDK–cyclin A
ATP
ATP
N
H
C
O
S
26S Proteasome
RP
C
O
HECT-type
Cellular Pathways Associated with the Proteasome
HECT
RING Finger
GeneExpression
GeneExpression
Pro-survivalPathway
Senescence
E1
DUBs
DUBs
DUBs
DUBs
NF-κB
Mdm2
p53
p53
p53
IκB
NF-κB
IκB
IκB
NF-κB
IκB Kinase
E2
E3
E3
E2
Cellular Stress
ARF
Stress
Apoptosis
S
S
S
E1 Activating InhibitorsPevonedistatPYR-41TAK-243
DUB InhibitorsPR-619P5091P22077IU1ML323
DUB InhibitorsPR-619P5091P22077IU1ML323
Pan-Proteasome InhibitorsCarfilzomibEpoxomicinSelective Proteasome InhibitorsMG-132 (26S Proteasome)Bortezomib (20S Proteasome)Ixazomib (20S Proteasome)Celastrol (20S Proteasome)
E2 Conjugating InhibitorsBAY 11-7082NSC697923
Mdm2 InhibitorsNutlin-3Nutlin-3aIdasanutlinHDM201
p53 ActivatorsAPR-246CBL0137p53 InhibitorsPifithrin-αPifithrin-μ
E3 Ligase Activator(-)-ParthenolideE3 Ligase AntagonistsThalidomideJNJ-26854165Nutlin-3E3 Ligase ModulatorAvadomide
Pan-IκB/IKK InhibitorsBardoxolone MethylIKK-16Selective IκB/IKK InhibitorsMRT67307 (IKKϵ)IMD 0354 (IKKβ)TPCA-1 (IKK-2)
NF-κB InhibitorsBAY 11-7082JSH-23QNZSC75741Pyrrolidinedithiocarbamate
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RING-type
RING Finger
HECT-type
HECT
26S Proteasome
ATP
ATP
AMP+PPi
ADP+Pi
Cellular Pathways Associated with the Proteasome
Cellular Stress
Stress
WAF1
CDC25C
CDC25B
CDK-cyclin A
CDK-cyclin B
CDK-cyclin A
CDK-cyclin D
CDK-cyclin E
Proteasome Inhibition
Proteasome Inhibition
Proteasome Inhibition
G0
G1
G2
S
M
Senescence
O
O
C
C
S
S
N
H
RP
CDC25A, CDC25C
KIP1
Pro-survival
Pathway
Gene
Expression
Gene
Expression
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Notes:
1:Clickable
2:Unclickable