P
Notes:
1:Clickable
2:Unclickable
Gαq
βγ
Gαq
βγ
TRAF1
Others
GTP
Forkheads
Forkheads
DAG
Ca
2+
IP
3
HypertrophyApoptosis
Bad
14-3-3
14-3-3
Crk
ILK
Bad
14-3-3
Bad
Bad
Phosphorylation, Translocation ofTranscription Factors(e.g. Elk-1, c-myc, STAT-3)
Phosphorylation, Translocation ofTranscription Factors(e.g. c-jun, ATF-2, Elk-1)
Transcriptional Activation ofSurvival Genes(e.g. Bcl-2, IAPs, c-myc, IкBα)
p130cas
Prepro ET-1
Furin and PC7 Convertases
ECE-1a-d (at pH 7)
ECE-1b-d (at pH 5.5)
Big ET-1
ET-1
FasLTNF
Integrin
Apoptosis
Apoptosis
Apoptosis
Apoptosis
Apoptosis
NF-кB
Signaling
ET Receptor
A
ET Receptor
A
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