P P P ER ER ER ER cAMP PKA Bcl-2 Akt PI3K Src Ras Raf IKKs NF-κB NF-κB MAPKs JNKs p38 ERK1/2 HDACs AR AR HSP HSP 5α-Reductase JAK1 STAT3 MEK ERK1/2 PI3K Src Akt cAMP PKA Growth Factors Estrogen Estrogen Estrogen Estrogen Estrogen Estrogen Gα Gβ Gγ CREB eNOS NO SHC MEKKs GRB2 SOS RTKs CREB Sp1 c-Jun c-Fos Elk1 PELP1 BRG1 E6AP Sim3 NCOR BRCA1 RP-A RTA REA p72 TRAP220 P6S PGC1 SRA AIB1 SRC1 TIF2 AR AR Cyclin D1 SHP DAX1 RIP140 T DHT p300 Ras GPCR Antiapoptosis Vasodilation GeneExpression IL-6R RTK IGF-1EGF Src InhibitorsDasatinibSaracatinibPP2Bosutinib cAMP ActivatorForskolincAMP InhibitorSQ22536 Pan-PI3K Inhibitors3-MethyladenineLY294002DactolisibWortmanninSelective PI3K InhibitorsAlpelisib (PI3Kα)TGX-221 (p110β)AS-252424 (PI3Kγ)Idelalisib (p110δ) Estrogen Receptor AntagonistsFulvestrantTamoxifenMifepristoneRaloxifeneEstrogen Receptor AgonistsEstradiolProgesterone 5-alpha Reductase InhibitorsDutasterideFinasteride Androgen ReceptorAntagonistsEnzalutamideApalutamideBicalutamideDarolutamideAndrogen Receptor AgonistDihydrotestosterone P {{ board.text }} Growth Factors IL-6R Vasodilation Antiapoptosis IGF-1 EGF Gene Expression {{ board.text }} {{ board.text }} 5α-Reductase {{ group.title }} {{ text.text }} {{ button.text }} {{ group.title }} {{ text.text }} Notes: 1:Clickable 2:Unclickable