+
MYD88
JAK-STAT
NF-κB
IRAK
pSTAT3
p38 MAPK
IRS1
SOCS3
PI3K
pAkt
PKCθ/PP2A
SIRT1
PDH
ACC
AMPK
CAMKKβ
CDK5
PPARγ
SIRT1
PGC-1α
PPARγ
pCREB
PPARγ
C/EBPβ
C/EBPα
LKB1
TCS1/2
mTORC
JNK
TRAF6
IKK
NEMO
PKA
Lipolysis
Lipogenesis
Adiponectin
HIF-1αDestabilization
GlycerolNeogenesis
Glut4Translocation
Autophagy
BCAACatabolism
Adipocyte-specificGene Expression
NF-κB-mediatedInflammation
Chaperones RegulatingAdiponectin Secretion
MitochondrialBiogenesisProgram
FAOxidation
OXPHOS
NormalOxidativeStress
LPL
HSL
MGL
ATGL
CGI-58
TNFα
FATP
FAs
FAs
CD36
ATP
Glucose
O
2
(Normoxia)
Caveolins
LipoproteinParticles
SNS Signaling
β3AR
Glucose
TNFR
Insulin R
M2 Macrophage
IL-10(Anti-inflammatory)
Insulin
Adipo R
S1P
S1PR
S1P
Ca
2+
BCAAs
GOLGI
Malonyl-CoA
Acetyl-CoA
Glucose
Perilipins
Pyruvate
LIPIDDROPLET
CPT1
[AMP:ATP]
UCP1
Citrate
ROS
ROS
Cytosol
Nucleus
NAD
+
/NADH
Acetyl-CoA
Mitochondria(Normal Function)
Ceramide
Ceramide
FGF21
IL-6
SaturatedFAs
TLR4
FGFRs/βKlotho
AdiponectinRelease
(to OtherOrgans)
Glut4
SLC6
gp130
IL-6R
gp130
AC
Gsα
cAMP
TG
FSP27
CIDEA
InsulinSignaling
PKA InhibitorH 89PKA ActivatorsDibutyryl-cAMP8-Bromo-cAMP
Pan-Akt InhibitorsMK-2206IpatasertibCapivasertibAkt ActivatorSC79Selective Akt InhibitorsA-674563 (AKT1)CCT128930 (AKT2)
TNF-alpha InhibitorsPomalidomideLenalidomide
PPARγ AntagonistsT0070907GW9662PPARγ AgonistsRosiglitazonePioglitazoneTroglitazone
mTOR InhibitorsRapamycinEverolimusAZD8055Torin 1SapanisertibmTOR Agonist3BDO
P
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FAs
CD36
Lipolysis
Caveolins
Glucose
Glucose
Glucose
SNS Signaling
TNFR
Insulin R
Adipo R
Adiponectin
S1P
S1P
M2 Macrophage
BCAAs
FGF21
TLR4
CIDEA
FSP27
FAs
Lipogenesis
ATP
TG
Perilipins
Cytosol
Nucleus
(Normoxia)
O
2
NAD
/NADH
+
Pyruvate
Ceramide
Ceramide
[AMP:ATP]
GOLGI
OXPHOS
Citrate
PDH
ROS
ROS
CPT1
UCP1
Ca
2+
FATP
Glut4
SLC6
gp130
IL-6R
gp130
Lipoprotein
Particles
IL-10
(Anti-inflammatory)
Adiponectin
Release
(to Other
Organs)
FGFRs/
βKlotho
Saturated
FAs
Glycerol
Neogenesis
LIPID
DROPLET
Insulin
Signaling
HIF-1α
Destabilization
Mitochondrial
Biogenesis
Program
Normal
Oxidative
Stress
Chaperones Regulating
Adiponectin Secretion
Adipocyte-specific
Gene Expression
NF-κB-mediated
Inflammation
Glut4
Translocation
Mitochondria
(Normal Function)
Acetyl-
CoA
Malonyl-
CoA
BCAA
Catabolism
FA
Oxidation
Acetyl-
CoA
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Notes:
1:Clickable
2:Unclickable