GLUT2
GLUT1
TightJunction
TightJunction
Na
+
Na
+
Na
+
K
+
K
+
Glucose
Glucose
Glucose
Tubular Lumen
Kidneys
ApicalMembrane
Proximal TubuleEpithelial Cell
Intestinal Lumen
Dietary Glucose
High Dietary Na
+
Cl
-
Cytosol
Low Na
+
High K
+
Blood
High Na
+
Low K
+
ATP
ADP+P
i
2Na
+
Na
+
Na
+
K
+
K
+
Glucose
Glucose
Glucose
Small Intestine
S1&S2 Segment SGLT2 (>90% Glucose Reabsorbed)
S3 Segment SGLT1 (Remaining 10% Glucose Reabsorbed)
BasolateralMembrane
Interstitium
Notes:
1:Clickable
2:Unclickable
P
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Na /K
+
+
ATPase Pump
Na /K
+
+
ATPase Pump
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