MHC Class I
Peptide Presentation
TERT Peptide-specific
T-cell Receptor
Antigen-presenting Cell
• TERT Peptide(s)
• TERT mRNA
• TERT DNA Vectors
TERT Immunotherapy
TERT Peptide Presentation
to CD8 (or CD4) Cells
CD8
+
Cytotoxic T Cell
Co-regulatory Signals
TERT
Promoter-driven
Suicide
Gene Therapy
TERT Peptides
Golgi
Cell Lysis
Endoplasmic Reticulum
Telomere-associated
Proteins
Telomere-disrupting
Agents
DNA
Tumor Cell
Telomerase
Turnover
Assembly
Processing
Translation
Processing
Block Telomerase
Expression or
Biogenesis
hTR
TERT
Transcription
Telomerase
Genes
Active site
Template
Dyskerin
hTR
TTAGGGTTAGGGTTAGGGTTAG
AUCCCAAUC
chr.3
chr.5
5′
3′
P
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