P APC NMDA F2R/CD14 Integrin F2 Gα12,13 Rac1GEF RhoGEF Calcineurin ADF/Cofilin Rho Insulin, Growth Factor Gβγ SOS Ras Raf MEK ERK Rac ROCK1,2 PI3K Src FAK Cas Y421 Y456 Y482 CrkII Dock180 Cortactin Cortactin FN1 FGD1/3 Cdc42 IQGAP AdherensJunction NHE1 PI4P5K PAK ADF LIMK CFN ACTN FocalAdhesionAssembly Focal ComplexAssembly Stabilizationof Actin ProteinSynthesis Vav RAP1 GRLF1 Cortactin Integrin Clustering Actin PolymerizationStress Fiber PIP 3 PIP 2 VCL GIT1 PXN PIP 2 MLC MLCK MBS Profilin PIX PI4P5K Cofilin Cofilin mDia p27 p21 CDKAssembly PFN ERM F-Actin Arp2/3 NWASP Asef F-Actin eEF1A eEF1Bα,γ ActinPolymerization PFN TMSB4 Arp2/3 PIR121 Nap125 Abi2 IRSp53 HSPC300 WAVE1 WAVE2 F-Actin MyosinII LIMK1,2 Ca 2+ +P GPCR APC InhibitorTAME Pan-PI3K Inhibitors3-MethyladenineLY294002DactolisibWortmanninSelective PI3K InhibitorsAlpelisib (PI3Kα)TGX-221 (p110β)AS-252424 (PI3Kγ)Idelalisib (p110δ) Mutant B-RafV600EInhibitorsVemurafenibDabrafenibPLX-4720Pan-Raf InhibitorsSorafenibEncorafenibSelective Raf InhibitorsSB590885 (B-Raf)GW5074 (C-Raf) ERK InhibitorsSCH772984UlixertinibLY3214996Ravoxertinib Rac GTPase InhibitorsNSC 23766EHT 1864EHop-016 Src InhibitorsDasatinibSaracatinibPP2Bosutinib FAK InhibitorsDefactinibGSK2256098PF-573228PF-562271 P {{ board.text }} Integrin NMDA Insulin, Growth Factor Y421 Y456 Y482 +P Integrin Clustering Adherens Junction Actin PIP 2 PIP 2 PIP 3 Ca 2+ Polymerization Protein Synthesis Stabilization of Actin Focal Complex Assembly Actin Polymerization Stress Fiber Focal Adhesion Assembly CDK Assembly {{ board.text }} {{ board.text }} {{ group.title }} {{ text.text }} {{ button.text }} {{ group.title }} {{ text.text }} Notes: 1:Clickable 2:Unclickable