P P Notes: 1:Clickable 2:Unclickable FGF FGF nSH2 SH3 GAB1 cSH2 GRB2 SOS MAPKK MKP1 MKP3 SEFB SPRY SHP2 PLC-γ Ca 2+ IP 3 Y X PH C2 C Y196 PTB Y306 Y349 Y392 nPH cPH Y436 783 1253 771 Y471 PIP 2 N Target Genes Negative Feedback: for example, through SPRY, SEF, MAPKP3 and MKP1. Downstream Transcription Factors:for example, FOS, JUN and PEA3. N Nucleus FGFRL1 SEF P {{ board.text }} {{ board.text }} {{ board.text }} {{ board.text }} {{ group.title }} {{ text.text }} {{ button.text }} {{ group.title }} {{ text.text }}