P
P
Notes:
1:Clickable
2:Unclickable
FGF
FGF
nSH2
SH3
GAB1
cSH2
GRB2
SOS
MAPKK
MKP1
MKP3
SEFB
SPRY
SHP2
PLC-γ
Ca
2+
IP
3
Y
X
PH
C2
C
Y196
PTB
Y306
Y349
Y392
nPH
cPH
Y436
783
1253
771
Y471
PIP
2
N
Target Genes
Negative Feedback: for example, through SPRY, SEF, MAPKP3 and MKP1. Downstream Transcription Factors:for example, FOS, JUN and PEA3.
N
Nucleus
FGFRL1
SEF
P
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