Pasireotide (SOM230) is a multi-receptor ligand somatostatin analogue with high binding affinity for somatostatin receptor (SSTR) subtypes sst1,2,3 and sst5. It potently suppresses GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing’s disease.

Amino-acid Sequence

CAS No. 396091-73-9

Purity & Quality Control

Batch: P112701 DMSO] 100 mg/mL] false] Ethanol] 100 mg/mL] false] Water] Insoluble] false Purity: 99.47%

99.47

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (95.49 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Biological Activity

Description

Pasireotide (SOM230) is a multi-receptor ligand somatostatin analogue with high binding affinity for somatostatin receptor (SSTR) subtypes sst1,2,3 and sst5. It potently suppresses GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing’s disease.

Targets

SST2

9

References
[1] Lewis I, et al. J Med Chem. 2003 Jun 5;46(12):2334-44.

References

[1] Lewis I, et al. J Med Chem. 2003 Jun 5;46(12):2334-44.

Product Information

Molecular Formula:	C₅₈H₆₆N₁₀O₉
Molecular Weight:	1047.21
CAS No.:	396091-73-9
Appearance:	White Powder
Peptide Content (by %N):	≥80%
Single Impurity (by HPLC):	≤1.0%
Assay (By Anhydrous, Acetic Acid-free):	95.0~105.0%
MS:	Consistent
Packing:	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt):	3 years-20°C powder
Shipping:	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)