Home Transmembrane Transporters Calcium Channel inhibitor Azelnidipine For research use only.

Azelnidipine

Synonyms: UR-12592

Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker.

Azelnidipine Chemical Structure

Azelnidipine Chemical Structure

CAS: 123524-52-7

Selleck's Azelnidipine has been cited by 2 publications

Purity & Quality Control

Batch: S305301 DMSO] 117 mg/mL] false] Ethanol] 7 mg/mL] false] Water] Insoluble] false Purity: 99.97%
99.97

Azelnidipine Related Products

Signaling Pathway

Calcium Channel Signaling Pathways

Calcium Channel Signaling Pathway

Choose Selective Calcium Channel Inhibitors

Biological Activity

Description Azelnidipine (UR-12592) is a dihydropyridine calcium channel blocker.
Targets
Calcium channel [1]
In vitro
In vitro Azelnidipine is a newly developed long-acting calcium channel blocker with unique pharmacological features, e.g. cardiac slowing action and high affinity to vascular tissues, which distinguishes itself from other calcium channel blockers. Azelnidipine, thus, became a new generation of calcium channel blocker that can be used for the treatment of hypertensive patients with or without potential ischemic heart diseases. Because this new calcium antagonist is highly lipid soluble, it is retained in the vascular wall after clearance from the blood and continues to elicit a hypotensive effect.

Chemical Information & Solubility

Molecular Weight 582.65 Formula

C33H34N4O6
CAS No. 123524-52-7 SDF Download Azelnidipine SDF
Smiles CC1=C(C(C(=C(N1)N)C(=O)OC2CN(C2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC(C)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 117 mg/mL ( (200.8 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 7 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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