Phosphatidylserine

Name: Phosphatidylserine
Brand: Selleck Chemicals
SKU: E4372
Rating: 5 (1 reviews)

Synonyms: Distearoylphosphatidylserine

Catalog No.E4372

Phosphatidylserine (Distearoylphosphatidylserine) is a negatively charged glycerophospholipid found mainly in the plasma membrane (PM) and in the late secretory/endocytic compartments, where it regulates cellular activity and can mediate apoptosis It also inhibits inflammatory responses.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!

Phosphatidylserine Chemical Structure

CAS: 51446-62-9

Purity & Quality Control

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Biological Activity

Description	Phosphatidylserine (Distearoylphosphatidylserine) is a negatively charged glycerophospholipid found mainly in the plasma membrane (PM) and in the late secretory/endocytic compartments, where it regulates cellular activity and can mediate apoptosis It also inhibits inflammatory responses.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05675436	Enrolling by invitation	Sickle Cell Anemia\|Sickle Cell Thalassemia\|Sickle Cell Pain\|Hbss\|Hbsc\|Sickle Beta Thalassemia\|Sickle Beta Zero Thalassemia\|Sickle Cell Syndrome Variant	National Heart Lung and Blood Institute (NHLBI)\|National Institutes of Health Clinical Center (CC)	May 15 2024	--
NCT05861453	Recruiting	Sickle Cell Disease	Afimmune	January 10 2024	Phase 2
NCT06007248	Not yet recruiting	Coronary Artery Disease\|Coronary Artery Stenosis\|Coronary Artery Restenosis\|Coronary Artery Disease Progression\|Inflammation\|Inflammatory Disease\|Inflammation Vascular	Peking Union Medical College Hospital	August 2023	--
NCT04834713	Unknown status	Hemorrhagic Fever With Renal Syndrome	First Affiliated Hospital Xi''an Jiaotong University	October 9 2020	--

References

Chemical Information & Solubility

Molecular Weight	792.08	Formula	C₄₂H₈₂NO₁₀P
CAS No.	51446-62-9	SDF	Download Phosphatidylserine SDF
Storage (From the date of receipt)	3 years-20°Cpowder	Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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