Home Angiogenesis BTK inhibitor Poseltinib For research use only.

Poseltinib

Synonyms: HM71224, LY3337641

Poseltinib (HM71224, LY3337641) shows a highly selective inhibition for Bruton’s tyrosine kinase (BTK) with IC50 of 1.95 nM, in which the selectivity toward other BMX, TEC and TXK are 0.3, 2.3 and 2.4 fold, respectively. 

Poseltinib Chemical Structure

Poseltinib Chemical Structure

CAS: 1353552-97-2

Purity & Quality Control

Batch: E284301 DMSO] 94 mg/mL] false] Ethanol] 23 mg/mL] false] Water] Insoluble] false Purity: 99.31%
99.31

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Signaling Pathway

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BTK Signaling Pathway

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Biological Activity

Description Poseltinib (HM71224, LY3337641) shows a highly selective inhibition for Bruton’s tyrosine kinase (BTK) with IC50 of 1.95 nM, in which the selectivity toward other BMX, TEC and TXK are 0.3, 2.3 and 2.4 fold, respectively. 
Targets
BTK [1]
(in kinase assays)
1.95 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05335018 Recruiting
Relapsed/Refractory Diffuse Large B Cell Lymphoma
Seoul National University Hospital
 May 30 2022 Phase 2
NCT03083561 Completed
Healthy
Eli Lilly and Company
 March 15 2017 Phase 1
NCT02914379 Completed
Healthy
Eli Lilly and Company
 September 2016 Phase 1
NCT02628028 Terminated
Rheumatoid Arthritis
Eli Lilly and Company
 August 22 2016 Phase 2

Chemical Information & Solubility

Molecular Weight 470.52 Formula

C26H26N6O3
CAS No. 1353552-97-2 SDF --
Smiles CN1CCN(CC1)C2=CC=C(NC3=NC(=C4OC=CC4=N3)OC5=CC(=CC=C5)NC(=O)C=C)C=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 94 mg/mL ( (199.77 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 23 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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